TY  - JOUR
A1  - Kraus, Sara Milena
A1  - Mathew-Stephen, Mariet
A1  - Schapranow, Matthieu-Patrick
T1  - Eatomics
BT  - Shiny exploration of quantitative proteomics data
JF  - Journal of proteome research
N2  - Quantitative proteomics data are becoming increasingly more available, and as a consequence are being analyzed and interpreted by a larger group of users. However, many of these users have less programming experience. Furthermore, experimental designs and setups are getting more complicated, especially when tissue biopsies are analyzed. Luckily, the proteomics community has already established some best practices on how to conduct quality control, differential abundance analysis and enrichment analysis. However, an easy-to-use application that wraps together all steps for the exploration and flexible analysis of quantitative proteomics data is not yet available. For Eatomics, we utilize the R Shiny framework to implement carefully chosen parts of established analysis workflows to (i) make them accessible in a user-friendly way, (ii) add a multitude of interactive exploration possibilities, and (iii) develop a unique experimental design setup module, which interactively translates a given research hypothesis into a differential abundance and enrichment analysis formula. In this, we aim to fulfill the needs of a growing group of inexperienced quantitative proteomics data analysts. Eatomics may be tested with demo data directly online via https://we.analyzegenomes.com/now/eatomics/or with the user's own data by installation from the Github repository at https://github.com/Millchmaedchen/Eatomics.
KW  - R Shiny
KW  - application
KW  - label-free
KW  - proteomics
KW  - analysis
KW  - differential
KW  - abundance
KW  - experimental design
Y1  - 2021
U6  - https://doi.org/10.1021/acs.jproteome.0c00398
SN  - 1535-3893
SN  - 1535-3907
VL  - 20
IS  - 1
SP  - 1070
EP  - 1078
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - GEN
A1  - Giebler, Heiko
A1  - Ruth, Saskia P.
A1  - Tanneberg, Dag
T1  - Why choice matters
BT  - revisiting and comparing measures of democracy
T2  - Politics and Governance
N2  - Measures of democracy are in high demand. Scientific and public audiences use them to describe political realities and to substantiate causal claims about those realities. This introduction to the thematic issue reviews the history of democracy measurement since the 1950s. It identifies four development phases of the field, which are characterized by three recurrent topics of debate: (1) what is democracy, (2) what is a good measure of democracy, and (3) do our measurements of democracy register real-world developments? As the answers to those questions have been changing over time, the field of democracy measurement has adapted and reached higher levels of theoretical and methodological sophistication. In effect, the challenges facing contemporary social scientists are not only limited to the challenge of constructing a sound index of democracy. Today, they also need a profound understanding of the differences between various measures of democracy and their implications for empirical applications. The introduction outlines how the contributions to this thematic issue help scholars cope with the recurrent issues of conceptualization, measurement, and application, and concludes by identifying avenues for future research.
KW  - application
KW  - conceptualization
KW  - democracy
KW  - democratic quality
KW  - measurement
Y1  - 2018
U6  - https://doi.org/10.17645/pag.v6i1.1428
SN  - 2183-2463
VL  - 6
IS  - 1
SP  - 1
EP  - 10
PB  - Cogitatio Press
CY  - Lisbon
ER  - 
TY  - GEN
A1  - Giebler, Heiko
A1  - Ruth, Saskia P.
A1  - Tanneberg, Dag
T1  - Why choice matters
BT  - revisiting and comparing measures of democracy
T2  - Postprints der Universität Potsdam Wirtschafts- und Sozialwissenschaftliche Reihe
N2  - Measures of democracy are in high demand. Scientific and public audiences use them to describe political realities and to substantiate causal claims about those realities. This introduction to the thematic issue reviews the history of democracy measurement since the 1950s. It identifies four development phases of the field, which are characterized by three recurrent topics of debate: (1) what is democracy, (2) what is a good measure of democracy, and (3) do our measurements of democracy register real-world developments? As the answers to those questions have been changing over time, the field of democracy measurement has adapted and reached higher levels of theoretical and methodological sophistication. In effect, the challenges facing contemporary social scientists are not only limited to the challenge of constructing a sound index of democracy. Today, they also need a profound understanding of the differences between various measures of democracy and their implications for empirical applications. The introduction outlines how the contributions to this thematic issue help scholars cope with the recurrent issues of conceptualization, measurement, and application, and concludes by identifying avenues for future research.
T3  - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe - 104 
KW  - application
KW  - conceptualization
KW  - democracy
KW  - democratic quality
KW  - measurement
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427891
SN  - 1867-5808
IS  - 104
ER  -