TY  - JOUR
A1  - Secker, Christian
A1  - Voelkel, Antje
A1  - Tiersch, Brigitte
A1  - Koetz, Joachim
A1  - Schlaad, Helmut
T1  - Thermo-Induced Aggregation and Crystallization of Block Copolypeptoids in Water
JF  - Macromolecules : a publication of the American Chemical Society
N2  - Block copolypeptoids comprising a thermosensitive, crystallizable poly(N-(n-propyl)glycine) block and a watersoluble poly(N-methylglycine) block, P70My (y = 23, 42, 76, 153, and 290), were synthesized bY ring-opening polymerization of the corresponding N-alkylglycine N-carboxyanhydrides (NCAs) and examined according to their thermo-induced aggregation and crystallization in water by turbidimetty, micro-differential scanning calorimetry (micro-DSC); cryogenic scanning electron microscopy (cryo-SEM), analytical ultracentrifugation (AUC), and static light scattering (SLS). At a temperature above the cloud point temperature, the initially formed micellar aggregates started to crystallize and grow into larger complex assemblies of about 100-500 nm, exhibiting flower-like (P70M23), ellipsoidal (P70M42 and P70M72) or irregular shapes (P70M153 and.P70M290).
Y1  - 2016
U6  - https://doi.org/10.1021/acs.macromol.5b02481
SN  - 0024-9297
SN  - 1520-5835
VL  - 49
SP  - 979
EP  - 985
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Thielke, Michael W.
A1  - Secker, Christian
A1  - Schlaad, Helmut
A1  - Theato, Patrick
T1  - Electrospinning of Crystallizable Polypeptoid Fibers
JF  - Macromolecular rapid communications
N2  - A unique fabrication process of low molar mass, crystalline polypeptoid fibers is described. Thermoresponsive fiber mats are prepared by electrospinning a homogeneous blend of semicrystalline poly(N-(n-propyl) glycine) (PPGly; 4.1 kDa) with high molar mass poly(ethylene oxide) (PEO). Annealing of these fibers at approximate to 100 degrees C selectively removes the PEO and produces stable crystalline fiber mats of pure PPGly, which are insoluble in aqueous solution but can be redissolved in methanol or ethanol. The formation of water-stable polypeptoid fiber mats is an important step toward their utilization in biomedical applications such as tissue engineering or wound dressing.
KW  - biomaterials
KW  - crystallization
KW  - electrospinning
KW  - polypeptoids
KW  - thermoresponsive
Y1  - 2016
U6  - https://doi.org/10.1002/marc.201500502
SN  - 1022-1336
SN  - 1521-3927
VL  - 37
SP  - 100
EP  - 104
PB  - Wiley-VCH
CY  - Weinheim
ER  -