TY  - JOUR
A1  - Kumar, Reddi K.
A1  - Basu, Sayantani
A1  - Lemke, Horst-Dieter
A1  - Jankowski, Joachim
A1  - Kratz, Karl
A1  - Lendlein, Andreas
A1  - Tetali, Sarada D.
T1  - Effect of extracts of poly(ether imide) microparticles on cytotoxicity, ROS generation and proinflammatory effects on human monocytic (THP-1) cells
JF  - Clinical hemorheology and microcirculation : blood flow and vessels
N2  - A high cell viability of around 99 +/- 18% and 99 +/- 5% was observed when THP-1 cells were cultured in the presence of aqueous extracts of the PEI microparticles in medium A and medium B respectively. The obtained microscopic data suggested that PEI particle extracts have no significant effect on cell death, oxidative stress or differentiation to macrophages. It was further found that the investigated proinflammatory markers in THP-1 cells were not up-regulated. These results are promising with regard to the biocompatibility of PEI microparticles and in a next step the hemocompatibility of the microparticles will be examined.
KW  - Chronic kidney disease (CKD)
KW  - cytotoxicity
KW  - human monocytic (THP-1) cells
KW  - poly(ether imide) microparticles
KW  - reactive oxygen species (ROS)
Y1  - 2016
U6  - https://doi.org/10.3233/CH-152027
SN  - 1386-0291
SN  - 1875-8622
VL  - 61
SP  - 667
EP  - 680
PB  - IOS Press
CY  - Amsterdam
ER  -