TY  - JOUR
A1  - Kerubo, Leonidah Omosa
A1  - Midiwo, Jacob Ogweno
A1  - Derese, Solomon
A1  - Langat, Moses K.
A1  - Akala, Hoseah M.
A1  - Waters, Norman C.
A1  - Peter, Martin
A1  - Heydenreich, Matthias
T1  - Antiplasmodial activity of compounds from the surface exudates of senecio roseiflorus
JF  - Natural product communications : an international journal for communications and reviews
N2  - From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.
KW  - Senecio roseiflorus
KW  - Asteraceae
KW  - Surface exudates
KW  - Antiplasmodial activity
Y1  - 2013
SN  - 1934-578X
VL  - 8
IS  - 2
SP  - 175
EP  - 176
PB  - NPC
CY  - Westerville
ER  - 
TY  - JOUR
A1  - Andayi, Andrew W.
A1  - Yenesew, Abiy
A1  - Derese, Solomon
A1  - Midiwo, Jacob O.
A1  - Gitu, Peter M.
A1  - Jondiko, Ogoche J. I.
A1  - Akala, Hoseah M.
A1  - Liyala, Pamela
A1  - Wangui, Julia
A1  - Waters, Norman C.
A1  - Heydenreich, Matthias
A1  - Peter, Martin G.
T1  - Antiplasmodial flavonoids from Erythrina sacleuxii
N2  - The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'- prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence
Y1  - 2006
UR  - http://www.thieme-connect.com/ejournals/toc/plantamedica
U6  - https://doi.org/10.1055/s-2005-873200
SN  - 0032-0943
ER  - 
TY  - JOUR
A1  - Yenesew, Abiy
A1  - Induli, M.
A1  - Derese, Solomon
A1  - Midiwo, Jacob O.
A1  - Heydenreich, Matthias
A1  - Peter, Martin G.
A1  - Akala, Hoseah M.
A1  - Wangui, Julia
A1  - Liyala, Pamela
A1  - Waters, Norman C.
T1  - Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica
N2  - The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 7.9 +/- 1.1 and 5.3 +/- 0.7 mug/ml, respectively. From this extract, a new chalcone, 2,3,4,4'-tetrahydroxy-5- prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'- prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti- plasmodial principles. The structures were determined on the basis of spectroscopic evidence. (C) 2004 Elsevier Ltd. All rights reserved
Y1  - 2004
SN  - 0031-9422
ER  -