TY  - JOUR
A1  - Giulbudagian, Michael
A1  - Hönzke, Stefan
A1  - Bergueiro, Julián
A1  - Işık, Doğuş
A1  - Schumacher, Fabian
A1  - Saeidpour, Siavash
A1  - Lohan, Silke
A1  - Meinke, Martina
A1  - Teutloff, Christian
A1  - Schäfer-Korting, Monika
A1  - Yealland, Guy
A1  - Kleuser, Burkhard
A1  - Hedtrich, Sarah
A1  - Calderón, Marcelo
T1  - Enhanced topical delivery of dexamethasone by beta-cyclodextrin decorated thermoresponsive nanogels
JF  - Nanoscale
N2  - Highly hydrophilic, responsive nanogels are attractive as potential systems for the topical delivery of bioactives encapsulated in their three-dimensional polymeric scaffold. Yet, these drug carrier systems suffer from drawbacks for efficient delivery of hydrophobic drugs. Addressing this, β-cyclodextrin (βCD) could be successfully introduced into the drug carrier systems by exploiting its unique affinity toward dexamethasone (DXM) as well as its role as topical penetration enhancer. The properties of βCD could be combined with those of thermoresponsive nanogels (tNGs) based on dendritic polyglycerol (dPG) as a crosslinker and linear thermoresponsive polyglycerol (tPG) inducing responsiveness to temperature changes. Electron paramagnetic resonance (EPR) studies localized the drug within the hydrophobic cavity of βCD by differences in its mobility and environmental polarity. In fact, the fabricated carriers combining a particulate delivery system with a conventional penetration enhancer, resulted in an efficient delivery of DXM to the epidermis and the dermis of human skin ex vivo (enhancement compared to commercial DXM cream: ∼2.5 fold in epidermis, ∼30 fold in dermis). Furthermore, DXM encapsulated in βCD tNGs applied to skin equivalents downregulated the expression of proinflammatory thymic stromal lymphopoietin (TSLP) and outperformed a commercially available DXM cream.
Y1  - 2017
U6  - https://doi.org/10.1039/c7nr04480a
SN  - 2040-3364
SN  - 2040-3372
VL  - 10
IS  - 1
SP  - 469
EP  - 479
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -