TY  - JOUR
A1  - Karuwanarint, Piyaporn
A1  - Phonrat, Benjaluck
A1  - Tungtrongchitr, Anchalee
A1  - Suriyaprom, Kanjana
A1  - Chuengsamarn, Somlak
A1  - Schweigert, Florian J.
A1  - Tungtrongchitr, Rungsunn
T1  - Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome
JF  - Biomarkers in medicine
N2  - Aim: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GCglobulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.
KW  - GC gene
KW  - GC-globulin
KW  - metabolic syndrome
KW  - polymorphism
KW  - Thai population
KW  - vitamin D-binding protein
Y1  - 2018
U6  - https://doi.org/10.2217/bmm-2018-0029
SN  - 1752-0363
SN  - 1752-0371
VL  - 12
IS  - 5
SP  - 465
EP  - 473
PB  - Future Medicine
CY  - London
ER  - 
TY  - JOUR
A1  - Chupeerach, Chaowanee
A1  - Harnroongroj, Talabporn
A1  - Phonrat, Benjaluck
A1  - Tungtrongchitr, Anchalee
A1  - Schweigert, Florian J.
A1  - Tungtrongchitr, Rungsunn
A1  - Preutthipan, Sangchai
T1  - Decreased retinol transport proteins in thai post-menopausal women with Osteporosis
JF  - The Southeast Asian journal of tropical medicine and public health : official publication of the SEAMEO Regional Tropical Medicine and Public Health Project (TROPMED)
N2  - High vitamin A ingestion or high serum retinol have been postulated to increase the risk of fractures and osteoporosis by reduced bone mineral density (BMD). Retinol is carried and transported to the tissues bound to retinol binding protein 4 (RBP4) and transthyretin (TTR). The relationships between retinol, retinol transport protein, retinol binding protein 4 (RBP4) and transthyretin (TTR) and BMD and osteoporosis are unclear. To examine the association between retinol and RBP4 and TTR and osteoporosis, 73 osteoporotic and 71 normal Thai postmenopausal women were studied. RBP4 and retinol levels did not differ between the groups. Serum TTR was significantly higher in control than osteoporotic subjects (89.47 and 144.53 mu g/ml, respectively, p=0.003, Mann-Whitney U test). TTR was positively correlated with BMD at several sites, such as the total radius bone (r=0.172, p=0.008, Spearman rank test). Osteoporosis risk was analyzed with binary logistic regression. Lean elderly Thais with lower TTR levels had a higher risk of osteoporosis. RBP4 and retinol levels had no relationship with disease status among Thai post-menopausal women. These results suggest calcium, minerals, vitamins and the retinol transport protein, transthyretin may be involved in the pathogenesis of osteoporosis.
KW  - transthyretin
KW  - vitamin A
KW  - retinol binding protein 4
KW  - post-menopausal Thai women
Y1  - 2011
SN  - 0125-1562
VL  - 42
IS  - 6
SP  - 1515
EP  - 1520
PB  - SEAMEO
CY  - Bangkok
ER  - 
TY  - JOUR
A1  - Chupeerach, Chaowanee
A1  - Tungtrongchitr, Anchalee
A1  - Phonrat, Benjaluck
A1  - Schweigert, Florian J.
A1  - Tungtrongchitr, Rungsunn
A1  - Preutthipan, Sangchai
T1  - Association of Thr420Lys polymorphism in DBP gene with fat-soluble vitamins and low radial bone mineral density in postmenopausal Thai women
JF  - Biomarkers in medicine
N2  - Aims: To investigate the genetic markers for osteoporosis bone mineral density by the genotyping of rs7041, rs4588 and rs1352845 in the DBP gene with either bone mineral density or serum 25-hydroxycholecalciferol, retinol and alpha-tocopherol, among 365 postmenopausal Thai women. Materials & methods: The DBP genotypes were analyzed by a PCR restriction fragment-length polymorphism method. Serum 25-hydroxycholecalciferol was assessed using a commercial chemiluminescent immunoassay. Serum retinol and alpha-tocopherol were measured by reverse-phase high-performance liquid chromatography. Results: After adjustment for age >50 years, elder Thai subjects with low BMI (<= 25 kg/m(2)) and carrying the rs4588 CC genotype had a higher risk of radial bone mineral density osteoporosis (odds ratio: 6.29; p = 0.048). The rs1352845 genotype also had a statistical association with total hip bone mineral density; however, it disappeared after adjustment for age and BMI. No association was found in fat-soluble vitamins with bone mineral density. Conclusion: DBP genotypes may influence the osteoporosis bone mineral density in postmenopausal Thai women.
KW  - bone mineral density
KW  - fat-soluble vitamin
KW  - osteoporosis
KW  - single nucleotide polymorphism
KW  - vitamin D binding protein
Y1  - 2012
U6  - https://doi.org/10.2217/BMM.11.88
SN  - 1752-0363
VL  - 6
IS  - 1
SP  - 103
EP  - 108
PB  - Future Medicine
CY  - London
ER  -