TY  - GEN
A1  - Stuchtey, Fidelis Christin
A1  - Block, Andrea
A1  - Osei, Francis
A1  - Wippert, Pia-Maria
T1  - Lipid Biomarkers in Depression: Does Antidepressant Therapy Have an Impact?
T2  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - Studies have revealed mixed results on how antidepressant drugs affect lipid profiles of patients with major depression disorder (MDD). Even less is known about how patients respond to a switch of antidepressant medication with respect to their metabolic profile. For this, effects of a switch in antidepressants medication on lipid markers were studied in MDD patients. 15 participants (females = 86.67%; males = 13.33%; age: 49.45 ± 7.45 years) with MDD and a prescribed switch in their antidepressant medication were recruited at a psychosomatic rehabilitation clinic. Participants were characterized (with questionnaires and blood samples) at admission to the rehabilitation clinic (baseline, T0) and followed up with a blood sample two weeks (T1) later. HDL, LDL, total cholesterol, and triglycerides were determined (T0), and their change analyzed (Wilcoxon test) at follow up (T1). Decrements in HDL (p = 0.041), LDL (p < 0.001), and total cholesterol (p < 0.001) were observed two weeks after a switch in antidepressant medication. Triglycerides showed no difference (p = 0.699). Overall, LDL, HDL, and total cholesterol are affected by a change in antidepressant drugs in patients with MDD. These observations are of clinical relevance for medical practitioners in the planning and management of treatment strategies for MDD patients.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 776 
KW  - major depressive disorder
KW  - antidepressants
KW  - high density lipoprotein cholesterol
KW  - HDL
KW  - low density lipoprotein cholesterol
KW  - LDL
KW  - cholesterol
KW  - triglycerides
KW  - lipids
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-560240
SN  - 1866-8364
SP  - 1
EP  - 11
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Stuchtey, Fidelis Christin
A1  - Block, Andrea
A1  - Osei, Francis
A1  - Wippert, Pia-Maria
T1  - Lipid Biomarkers in Depression: Does Antidepressant Therapy Have an Impact?
JF  - Healthcare : open access journal
N2  - Studies have revealed mixed results on how antidepressant drugs affect lipid profiles of patients with major depression disorder (MDD). Even less is known about how patients respond to a switch of antidepressant medication with respect to their metabolic profile. For this, effects of a switch in antidepressants medication on lipid markers were studied in MDD patients. 15 participants (females = 86.67%; males = 13.33%; age: 49.45 ± 7.45 years) with MDD and a prescribed switch in their antidepressant medication were recruited at a psychosomatic rehabilitation clinic. Participants were characterized (with questionnaires and blood samples) at admission to the rehabilitation clinic (baseline, T0) and followed up with a blood sample two weeks (T1) later. HDL, LDL, total cholesterol, and triglycerides were determined (T0), and their change analyzed (Wilcoxon test) at follow up (T1). Decrements in HDL (p = 0.041), LDL (p < 0.001), and total cholesterol (p < 0.001) were observed two weeks after a switch in antidepressant medication. Triglycerides showed no difference (p = 0.699). Overall, LDL, HDL, and total cholesterol are affected by a change in antidepressant drugs in patients with MDD. These observations are of clinical relevance for medical practitioners in the planning and management of treatment strategies for MDD patients.
KW  - major depressive disorder
KW  - antidepressants
KW  - high density lipoprotein cholesterol
KW  - HDL
KW  - low density lipoprotein cholesterol
KW  - LDL
KW  - cholesterol
KW  - triglycerides
KW  - lipids
Y1  - 2022
U6  - https://doi.org/10.3390/healthcare10020333
SN  - 2227-9032
VL  - 10
SP  - 1
EP  - 11
PB  - MDPI
CY  - Basel, Schweiz
ET  - 2
ER  -