TY  - JOUR
A1  - Librado, Pablo
A1  - Gamba, Cristina
A1  - Gaunitz, Charleen
A1  - Sarkissian, Clio Der
A1  - Pruvost, Melanie
A1  - Albrechtsen, Anders
A1  - Fages, Antoine
A1  - Khan, Naveed
A1  - Schubert, Mikkel
A1  - Jagannathan, Vidhya
A1  - Serres-Armero, Aitor
A1  - Kuderna, Lukas F. K.
A1  - Povolotskaya, Inna S.
A1  - Seguin-Orlando, Andaine
A1  - Lepetz, Sebastien
A1  - Neuditschko, Markus
A1  - Theves, Catherine
A1  - Alquraishi, Saleh A.
A1  - Alfarhan, Ahmed H.
A1  - Al-Rasheid, Khaled A. S.
A1  - Rieder, Stefan
A1  - Samashev, Zainolla
A1  - Francfort, Henri-Paul
A1  - Benecke, Norbert
A1  - Hofreiter, Michael
A1  - Ludwig, Arne
A1  - Keyser, Christine
A1  - Marques-Bonet, Tomas
A1  - Ludes, Bertrand
A1  - Crubezy, Eric
A1  - Leeb, Tosso
A1  - Willerslev, Eske
A1  - Orlando, Ludovic
T1  - Ancient genomic changes associated with domestication of the horse
JF  - Science
N2  - The genomic changes underlying both early and late stages of horse domestication remain largely unknown. We examined the genomes of 14 early domestic horses from the Bronze and Iron Ages, dating to between similar to 4.1 and 2.3 thousand years before present. We find early domestication selection patterns supporting the neural crest hypothesis, which provides a unified developmental origin for common domestic traits. Within the past 2.3 thousand years, horses lost genetic diversity and archaic DNA tracts introgressed from a now-extinct lineage. They accumulated deleterious mutations later than expected under the cost-of-domestication hypothesis, probably because of breeding from limited numbers of stallions. We also reveal that Iron Age Scythian steppe nomads implemented breeding strategies involving no detectable inbreeding and selection for coat-color variation and robust forelimbs.
Y1  - 2017
U6  - https://doi.org/10.1126/science.aam5298
SN  - 0036-8075
SN  - 1095-9203
VL  - 356
SP  - 442
EP  - 445
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - GEN
A1  - Jones, Eppie R.
A1  - González-Fortes, Gloria M.
A1  - Connell, Sarah
A1  - Siska, Veronika
A1  - Eriksson, Anders
A1  - Martiniano, Rui
A1  - McLaughlin, Russell L.
A1  - Llorente, Marcos Gallego
A1  - Cassidy, Lara M.
A1  - Gamba, Cristina
A1  - Meshveliani, Tengiz
A1  - Bar-Yosef, Ofer
A1  - Müller, Werner
A1  - Belfer-Cohen, Anna
A1  - Matskevich, Zinovi
A1  - Jakeli, Nino
A1  - Higham, Thomas F. G.
A1  - Currat, Mathias
A1  - Lordkipanidze, David
A1  - Hofreiter, Michael
A1  - Manica, Andrea
A1  - Pinhasi, Ron
A1  - Bradley, Daniel G.
T1  - Upper Palaeolithic genomes reveal deep roots of modern Eurasians
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - We extend the scope of European palaeogenomics by sequencing the genomes of Late Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old, 15.4-fold) males from western Georgia in the Caucasus and a Late Upper Palaeolithic (13,700 years old, 9.5-fold) male from Switzerland. While we detect Late Palaeolithic–Mesolithic genomic continuity in both regions, we find that Caucasus hunter-gatherers (CHG) belong to a distinct ancient clade that split from western hunter-gatherers ∼45 kya, shortly after the expansion of anatomically modern humans into Europe and from the ancestors of Neolithic farmers ∼25 kya, around the Last Glacial Maximum. CHG genomes significantly contributed to the Yamnaya steppe herders who migrated into Europe ∼3,000 BC, supporting a formative Caucasus influence on this important Early Bronze age culture. CHG left their imprint on modern populations from the Caucasus and also central and south Asia possibly marking the arrival of Indo-Aryan languages.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1334 
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-439317
SN  - 1866-8372
IS  - 1334
ER  - 
TY  - JOUR
A1  - Jones, Eppie R.
A1  - González-Fortes, Gloria M.
A1  - Connell, Sarah
A1  - Siska, Veronika
A1  - Eriksson, Anders
A1  - Martiniano, Rui
A1  - McLaughlin, Russell L.
A1  - Llorente, Marcos Gallego
A1  - Cassidy, Lara M.
A1  - Gamba, Cristina
A1  - Meshveliani, Tengiz
A1  - Bar-Yosef, Ofer
A1  - Mueller, Werner
A1  - Belfer-Cohen, Anna
A1  - Matskevich, Zinovi
A1  - Jakeli, Nino
A1  - Higham, Thomas F. G.
A1  - Currat, Mathias
A1  - Lordkipanidze, David
A1  - Hofreiter, Michael
A1  - Manica, Andrea
A1  - Pinhasi, Ron
A1  - Bradley, Daniel G.
T1  - Upper Palaeolithic genomes reveal deep roots of modern Eurasians
JF  - Nature Communications
N2  - We extend the scope of European palaeogenomics by sequencing the genomes of Late Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old, 15.4-fold) males from western Georgia in the Caucasus and a Late Upper Palaeolithic (13,700 years old, 9.5-fold) male from Switzerland. While we detect Late Palaeolithic-Mesolithic genomic continuity in both regions, we find that Caucasus hunter-gatherers (CHG) belong to a distinct ancient clade that split from western hunter-gatherers similar to 45 kya, shortly after the expansion of anatomically modern humans into Europe and from the ancestors of Neolithic farmers similar to 25 kya, around the Last Glacial Maximum. CHG genomes significantly contributed to the Yamnaya steppe herders who migrated into Europe similar to 3,000 BC, supporting a formative Caucasus influence on this important Early Bronze age culture. CHG left their imprint on modern populations from the Caucasus and also central and south Asia possibly marking the arrival of Indo-Aryan languages.
Y1  - 2015
U6  - https://doi.org/10.1038/ncomms9912
SN  - 2041-1723
VL  - 6
PB  - Nature Publishing Group
CY  - London
ER  - 
TY  - GEN
A1  - Gamba, Cristina
A1  - Jones, Eppie R.
A1  - Teasdale, Matthew D.
A1  - McLaughlin, Russell L.
A1  - González-Fortes, Gloria M.
A1  - Mattiangeli, Valeria
A1  - Domboróczki, László
A1  - Kővári, Ivett
A1  - Pap, Ildikó
A1  - Anders, Alexandra
A1  - Whittle, Alasdair
A1  - Dani, János
A1  - Raczky, Pál
A1  - Higham, Thomas F. G.
A1  - Hofreiter, Michael
A1  - Bradley, Daniel G.
A1  - Pinhasi, Ron
T1  - Genome flux and stasis in a five millennium transect of European prehistory
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including two to high (similar to 22x) and seven to similar to 1x coverage, to investigate the impact of these on Europe's genetic landscape. These data suggest genomic shifts with the advent of the Neolithic, Bronze and Iron Ages, with interleaved periods of genome stability. The earliest Neolithic context genome shows a European hunter-gatherer genetic signature and a restricted ancestral population size, suggesting direct contact between cultures after the arrival of the first farmers into Europe. The latest, Iron Age, sample reveals an eastern genomic influence concordant with introduced Steppe burial rites. We observe transition towards lighter pigmentation and surprisingly, no Neolithic presence of lactase persistence.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1332 
KW  - ancient DNA
KW  - lactase-persistence
KW  - positive selection
KW  - patterns
KW  - sequence
KW  - farmers
KW  - pigmentation
KW  - homozygosity
KW  - ancestry
KW  - skin
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437999
SN  - 1866-8372
VL  - 5
IS  - 1332
ER  - 
TY  - JOUR
A1  - Gamba, Cristina
A1  - Jones, Eppie R.
A1  - Teasdale, Matthew D.
A1  - McLaughlin, Russell L.
A1  - González-Fortes, Gloria M.
A1  - Mattiangeli, Valeria
A1  - Domboroczki, Laszlo
A1  - Kovari, Ivett
A1  - Pap, Ildiko
A1  - Anders, Alexandra
A1  - Whittle, Alasdair
A1  - Dani, Janos
A1  - Raczky, Pal
A1  - Higham, Thomas F. G.
A1  - Hofreiter, Michael
A1  - Bradley, Daniel G.
A1  - Pinhasi, Ron
T1  - Genome flux and stasis in a five millennium transect of European prehistory
JF  - Nature Communications
N2  - The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including two to high (similar to 22x) and seven to similar to 1x coverage, to investigate the impact of these on Europe's genetic landscape. These data suggest genomic shifts with the advent of the Neolithic, Bronze and Iron Ages, with interleaved periods of genome stability. The earliest Neolithic context genome shows a European hunter-gatherer genetic signature and a restricted ancestral population size, suggesting direct contact between cultures after the arrival of the first farmers into Europe. The latest, Iron Age, sample reveals an eastern genomic influence concordant with introduced Steppe burial rites. We observe transition towards lighter pigmentation and surprisingly, no Neolithic presence of lactase persistence.
Y1  - 2014
U6  - https://doi.org/10.1038/ncomms6257
SN  - 2041-1723
VL  - 5
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Gallego-Llorente, Marcos
A1  - Sarah, Connell
A1  - Jones, Eppie R.
A1  - Merrett, Deborah C.
A1  - Jeon, Y.
A1  - Eriksson, Anders
A1  - Siska, Veronika
A1  - Gamba, Cristina
A1  - Meiklejohn, Christopher
A1  - Beyer, Robert
A1  - Jeon, Sungwon
A1  - Cho, Yun Sung
A1  - Hofreiter, Michael
A1  - Bhak, Jong
A1  - Manica, Andrea
A1  - Pinhasi, Ron
T1  - The genetics of an early Neolithic pastoralist from the Zagros, Iran
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - The agricultural transition profoundly changed human societies. We sequenced and analysed the first genome (1.39x) of an early Neolithic woman from Ganj Dareh, in the Zagros Mountains of Iran, a site with early evidence for an economy based on goat herding, ca. 10,000 BP. We show that Western Iran was inhabited by a population genetically most similar to hunter-gatherers from the Caucasus, but distinct from the Neolithic Anatolian people who later brought food production into Europe. The inhabitants of Ganj Dareh made little direct genetic contribution to modern European populations, suggesting those of the Central Zagros were somewhat isolated from other populations of the Fertile Crescent. Runs of homozygosity are of a similar length to those from Neolithic farmers, and shorter than those of Caucasus and Western Hunter-Gatherers, suggesting that the inhabitants of Ganj Dareh did not undergo the large population bottleneck suffered by their northern neighbours. While some degree of cultural diffusion between Anatolia, Western Iran and other neighbouring regions is possible, the genetic dissimilarity between early Anatolian farmers and the inhabitants of Ganj Dareh supports a model in which Neolithic societies in these areas were distinct.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 952 
KW  - whole-genome association
KW  - ancient
KW  - domestication
KW  - agriculture
KW  - mountains
KW  - diffusion
KW  - migration
KW  - admixture
KW  - patterns
KW  - sequence
KW  - archaeology
KW  - biological anthropology
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-439355
SN  - 1866-8372
IS  - 952
ER  - 
TY  - JOUR
A1  - Fages, Antoine
A1  - Hanghoj, Kristian
A1  - Khan, Naveed
A1  - Gaunitz, Charleen
A1  - Seguin-Orlando, Andaine
A1  - Leonardi, Michela
A1  - Constantz, Christian McCrory
A1  - Gamba, Cristina
A1  - Al-Rasheid, Khaled A. S.
A1  - Albizuri, Silvia
A1  - Alfarhan, Ahmed H.
A1  - Allentoft, Morten
A1  - Alquraishi, Saleh
A1  - Anthony, David
A1  - Baimukhanov, Nurbol
A1  - Barrett, James H.
A1  - Bayarsaikhan, Jamsranjav
A1  - Benecke, Norbert
A1  - Bernaldez-Sanchez, Eloisa
A1  - Berrocal-Rangel, Luis
A1  - Biglari, Fereidoun
A1  - Boessenkool, Sanne
A1  - Boldgiv, Bazartseren
A1  - Brem, Gottfried
A1  - Brown, Dorcas
A1  - Burger, Joachim
A1  - Crubezy, Eric
A1  - Daugnora, Linas
A1  - Davoudi, Hossein
A1  - Damgaard, Peter de Barros
A1  - de Chorro y de Villa-Ceballos, Maria de los Angeles
A1  - Deschler-Erb, Sabine
A1  - Detry, Cleia
A1  - Dill, Nadine
A1  - Oom, Maria do Mar
A1  - Dohr, Anna
A1  - Ellingvag, Sturla
A1  - Erdenebaatar, Diimaajav
A1  - Fathi, Homa
A1  - Felkel, Sabine
A1  - Fernandez-Rodriguez, Carlos
A1  - Garcia-Vinas, Esteban
A1  - Germonpre, Mietje
A1  - Granado, Jose D.
A1  - Hallsson, Jon H.
A1  - Hemmer, Helmut
A1  - Hofreiter, Michael
A1  - Kasparov, Aleksei
A1  - Khasanov, Mutalib
A1  - Khazaeli, Roya
A1  - Kosintsev, Pavel
A1  - Kristiansen, Kristian
A1  - Kubatbek, Tabaldiev
A1  - Kuderna, Lukas
A1  - Kuznetsov, Pavel
A1  - Laleh, Haeedeh
A1  - Leonard, Jennifer A.
A1  - Lhuillier, Johanna
A1  - von Lettow-Vorbeck, Corina Liesau
A1  - Logvin, Andrey
A1  - Lougas, Lembi
A1  - Ludwig, Arne
A1  - Luis, Cristina
A1  - Arruda, Ana Margarida
A1  - Marques-Bonet, Tomas
A1  - Silva, Raquel Matoso
A1  - Merz, Victor
A1  - Mijiddorj, Enkhbayar
A1  - Miller, Bryan K.
A1  - Monchalov, Oleg
A1  - Mohaseb, Fatemeh A.
A1  - Morales, Arturo
A1  - Nieto-Espinet, Ariadna
A1  - Nistelberger, Heidi
A1  - Onar, Vedat
A1  - Palsdottir, Albina H.
A1  - Pitulko, Vladimir
A1  - Pitskhelauri, Konstantin
A1  - Pruvost, Melanie
A1  - Sikanjic, Petra Rajic
A1  - Papesa, Anita Rapan
A1  - Roslyakova, Natalia
A1  - Sardari, Alireza
A1  - Sauer, Eberhard
A1  - Schafberg, Renate
A1  - Scheu, Amelie
A1  - Schibler, Jorg
A1  - Schlumbaum, Angela
A1  - Serrand, Nathalie
A1  - Serres-Armero, Aitor
A1  - Shapiro, Beth
A1  - Seno, Shiva Sheikhi
A1  - Shevnina, Irina
A1  - Shidrang, Sonia
A1  - Southon, John
A1  - Star, Bastiaan
A1  - Sykes, Naomi
A1  - Taheri, Kamal
A1  - Taylor, William
A1  - Teegen, Wolf-Rudiger
A1  - Vukicevic, Tajana Trbojevic
A1  - Trixl, Simon
A1  - Tumen, Dashzeveg
A1  - Undrakhbold, Sainbileg
A1  - Usmanova, Emma
A1  - Vahdati, Ali
A1  - Valenzuela-Lamas, Silvia
A1  - Viegas, Catarina
A1  - Wallner, Barbara
A1  - Weinstock, Jaco
A1  - Zaibert, Victor
A1  - Clavel, Benoit
A1  - Lepetz, Sebastien
A1  - Mashkour, Marjan
A1  - Helgason, Agnar
A1  - Stefansson, Kari
A1  - Barrey, Eric
A1  - Willerslev, Eske
A1  - Outram, Alan K.
A1  - Librado, Pablo
A1  - Orlando, Ludovic
T1  - Tracking five millennia of horse management with extensive ancient genome time series
JF  - Cell
N2  - Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals and 129 ancient genomes (>= 1-fold coverage), 87 of which are new. This extensive dataset allows us to assess the modem legacy of past equestrian civilisations. We find that two extinct horse lineages existed during early domestication, one at the far western (Iberia) and the other at the far eastern range (Siberia) of Eurasia. None of these contributed significantly to modern diversity. We show that the influence of Persian-related horse lineages increased following the Islamic conquests in Europe and Asia. Multiple alleles associated with elite-racing, including at the MSTN "speed gene," only rose in popularity within the last millennium. Finally, the development of modem breeding impacted genetic diversity more dramatically than the previous millennia of human management.
Y1  - 2019
U6  - https://doi.org/10.1016/j.cell.2019.03.049
SN  - 0092-8674
SN  - 1097-4172
VL  - 177
IS  - 6
SP  - 1419
EP  - 1435
PB  - Cell Press
CY  - Cambridge
ER  -