TY - JOUR A1 - Tang, Kam W. A1 - Gladyshev, Michail I. A1 - Dubovskaya, Olgo P. A1 - Kirillin, Georgiy A1 - Grossart, Hans-Peter T1 - Zooplankton carcasses and non-predatory mortality in freshwater and inland sea environments JF - Journal of plankton research N2 - Zooplankton carcasses are ubiquitous in marine and freshwater systems, implicating the importance of non-predatory mortality, but both are often overlooked in ecological studies compared with predatory mortality. The development of several microscopic methods allows the distinction between live and dead zooplankton in field samples, and the reported percentages of dead zooplankton average 11.6 (minimum) to 59.8 (maximum) in marine environments, and 7.4 (minimum) to 47.6 (maximum) in fresh and inland waters. Common causes of non-predatory mortality among zooplankton include senescence, temperature change, physical and chemical stresses, parasitism and food-related factors. Carcasses resulting from non-predatory mortality may undergo decomposition leading to an increase in microbial production and a shift in microbial composition in the water column. Alternatively, sinking carcasses may contribute significantly to vertical carbon flux especially outside the phytoplankton growth seasons, and become a food source for the benthos. Global climate change is already altering freshwater ecosystems on multiple levels, and likely will have significant positive or negative effects on zooplankton non-predatory mortality. Better spatial and temporal studies of zooplankton carcasses and non-predatory mortality rates will improve our understanding of this important but under-appreciated topic. KW - carbon flux KW - inland waters KW - lakes KW - live KW - dead sorting KW - non-predatory mortality KW - zooplankton carcasses Y1 - 2014 U6 - https://doi.org/10.1093/plankt/fbu014 SN - 0142-7873 SN - 1464-3774 VL - 36 IS - 3 SP - 597 EP - 612 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Spahn, Hannah T1 - Reviews JF - Journal of American studies Y1 - 2014 U6 - https://doi.org/10.1017/S0021875814001042 SN - 0021-8758 SN - 1469-5154 VL - 48 IS - 3 SP - 880 EP - 882 PB - Cambridge Univ. Press CY - New York ER - TY - JOUR A1 - Shapiro, B. A1 - Hofreiter, Michael T1 - A paleogenomic perspective on evolution and gene function: new insights from ancient DNA JF - Science N2 - The publication of partial and complete paleogenomes within the last few years has reinvigorated research in ancient DNA. No longer limited to short fragments of mitochondrial DNA, inference of evolutionary processes through time can now be investigated from genome-wide data sampled as far back as 700,000 years. Tremendous insights have been made, in particular regarding the hominin lineage. With rare exception, however, a paleogenomic perspective has been mired by the quality and quantity of recoverable DNA. Though conceptually simple, extracting ancient DNA remains challenging, and sequencing ancient genomes to high coverage remains prohibitively expensive for most laboratories. Still, with improvements in DNA isolation and declining sequencing costs, the taxonomic and geographic purview of paleogenomics is expanding at a rapid pace. With improved capacity to screen large numbers of samples for those with high proportions of endogenous ancient DNA, paleogenomics is poised to become a key technology to better understand recent evolutionary events. Y1 - 2014 U6 - https://doi.org/10.1126/science.1236573 SN - 0036-8075 SN - 1095-9203 VL - 343 IS - 6169 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Scheller, Henrik T1 - Manual federalism - federalism as democratic legal order and legal culture in Germany, Europe and the world, vol 2, problems, reforms, perspectives of german federalism JF - Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung für Politische Wissenschaft Y1 - 2014 SN - 0032-3470 SN - 1862-2860 VL - 55 IS - 4 SP - 757 EP - 761 PB - Nomos CY - Hannover ER - TY - JOUR A1 - Scheller, Henrik T1 - Manual federalism - federalism as democratic legal order and legal culture in Germany, Europe and the World, vol 4, Federalism in Europe and the world JF - Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung für Politische Wissenschaft Y1 - 2014 SN - 0032-3470 SN - 1862-2860 VL - 55 IS - 4 SP - 757 EP - 761 PB - Nomos CY - Hannover ER - TY - JOUR A1 - Scheller, Henrik T1 - Manual Federalism - Federalism as democratic Legal Order and Legal Culture in Germany, Europe and the World, vol 1, Fundamentals of Federalism and the german Federal State JF - Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung für Politische Wissenschaft Y1 - 2014 SN - 0032-3470 SN - 1862-2860 VL - 55 IS - 4 SP - 757 EP - 761 PB - Nomos CY - Hannover ER - TY - JOUR A1 - Scheller, Henrik T1 - Manual Federalism - Federalism as democratic Legal Order and Legal Culture in Germany, Europe and the World JF - Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung für Politische Wissenschaft Y1 - 2014 SN - 0032-3470 SN - 1862-2860 VL - 55 IS - 4 SP - 757 EP - 761 PB - Nomos CY - Hannover ER - TY - JOUR A1 - Scheller, Henrik T1 - Manual federalism - federalism as democratic legal order and legal culture in Germany, Europe and the world, vol 3, development areas of the federalism JF - Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung für Politische Wissenschaft Y1 - 2014 SN - 0032-3470 SN - 1862-2860 VL - 55 IS - 4 SP - 757 EP - 761 PB - Nomos CY - Hannover ER - TY - JOUR A1 - Scheller, Henrik T1 - Political parties and public policy in the German Lander - When parties matter JF - Party politics : an international journal for the study of political parties and political organizations Y1 - 2014 U6 - https://doi.org/10.1177/1354068813510632 SN - 1354-0688 SN - 1460-3683 VL - 20 IS - 1 SP - 147 EP - 148 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Reichetzeder, Christoph A1 - Tsuprykov, Oleg A1 - Hocher, Berthold T1 - Endothelin receptor antagonists in clinical research - Lessons learned from preclinical and clinical kidney studies JF - Life sciences : molecular, cellular and functional basis of therapy N2 - Endothelin receptor antagonists (ETRAs) are approved for the treatment of pulmonary hypertension and scleroderma-related digital ulcers. The efforts to approve this class of drugs for renal indications, however, failed so far. Preclinical studies were promising. Transgenic overexpression of ET-1 or ET-2 in rodents causes chronic renal failure. Blocking the ET system was effective in the treatment of renal failure in rodent models. However, various animal studies indicate that blocking the renal tubular ETAR and ETBR causes water and salt retention partially mediated via the epithelial sodium transporter in tubular cells. ETRAs were successfully tested clinically in renal indications in phase 2 trials for the treatment of diabetic nephropathy. They showed efficacy in terms of reducing albumin excretion on top of guideline based background therapy (RAS blockade). However, these promising results could not be translated to successful phase Ill trials so far. The spectrum of serious adverse events was similar to other phase III trials using ETRAs. Potential underlying reasons for these failures and options to solve these issues are discussed. In addition preclinical and clinical studies suggest caution when addressing renal patient populations such as patients with hepatorenal syndrome, patients with any type of cystic kidney disease and patients at risk of contrast media induced nephropathy. The lessons learned in renal indications are also important for other potential promising indications of ETRAs like cancer and heart failure. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). KW - Endothelin receptor antagonists KW - Kidney KW - Side effects KW - Safety KW - Water and salt retention KW - Clinical trials Y1 - 2014 U6 - https://doi.org/10.1016/j.lfs.2014.02.025 SN - 0024-3205 SN - 1879-0631 VL - 118 IS - 2 SP - 141 EP - 148 PB - Elsevier CY - Oxford ER -