TY  - JOUR
A1  - Salmen, T.
A1  - Ermakova, Tatiana
A1  - Schindler, A.
A1  - Ko, S-R.
A1  - Göktas, O.
A1  - Gross, M.
A1  - Nawka, T.
A1  - Caffier, P. P.
T1  - Efficacy of microsurgery in Reinke's oedema evaluated by traditional voice assessment integrated with the Vocal Extent Measure (VEM)
JF  - Acta Otorhinolaryngol Italica
N2  - There are few data analysing to what specific extent phonomicrosurgery improves vocal function in patients suffering from Reinke's oedema (RE). The recently introduced parameter vocal extent measure (VEM) seems to be suitable to objectively quantify vocal performance. The purpose of this clinical prospective study was to investigate the outcomes of phonomicrosurgery in 60 RE patients (6 male, 54 female; 56 ± 8 years ([mean ± SD]) by analysing its effect on subjective and objective vocal parameters with particular regard to VEM. Treatment efficacy was evaluated at three months after surgery by comparing pre- and postoperative videolaryngostroboscopy (VLS), auditory-perceptual assessment (RBH-status), voice range profile (VRP), acoustic-aerodynamic analysis and patient's self-assessment using the voice handicap index (VHI-9i). Phonomicrosurgically, all RE were carefully ablated. VLS revealed removal or substantial reduction of oedema with restored periodic vocal fold vibration. All subjective and most objective acoustic and aerodynamic parameters significantly improved. The VEM increased on average from 64 ± 37 to 88 ± 25 (p #x003C; 0.001) and the dysphonia severity index (DSI) from 0.5 ± 3.4 to 2.9 ± 1.9. Both parameters correlated significantly with each other (rs = 0.70). RBH-status revealed less roughness, breathiness and overall grade of hoarseness (2.0 ± 0.7 vs 1.3 ± 0.7). The VHI-9i-score decreased from 18 ± 8 to 12 ± 9 points. The average total vocal range enlarged by 4 ± 7 semitones, and the mean speaking pitch rose by 2 ± 4 semitones. These results confirm that: (1) the use of VEM in RE patients objectifies and quantifies their vocal capacity as documented in the VRP, and (2) phonomicrosurgery is an effective, objectively and subjectively satisfactory therapy to improve voice in RE patients.
KW  - Voice function diagnostics
KW  - Voice range profile quantification
KW  - Vocal Extent Measure (VEM)
KW  - Reinke’s oedema
KW  - Phonomicrosurgery
Y1  - 2018
U6  - https://doi.org/10.14639/0392-100X-1544
SN  - 0392-100X
SN  - 1827-675X
VL  - 38
IS  - 3
SP  - 194
EP  - 203
PB  - Pacini editore
CY  - Pisa
ER  - 
TY  - JOUR
A1  - Nubel, K.
A1  - Kruck, S.
A1  - Höhle, Barbara
A1  - Suhl, U.
A1  - Weissenborn, Jürgen
A1  - Gross, M.
T1  - Interaktion behavioraler und elektrophysiologischer Ergebnisse zur Phonemdiskrimination bei Säuglingen
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Gross, M.
A1  - Müller, David C.
A1  - Nothofer, Heinz-Georg
A1  - Scherf, Ullrich
A1  - Neher, Dieter
A1  - Bräuchler, C.
A1  - Meerholz, Klaus
T1  - Improving the performance of doped p-conjugated polymers for use in organic light-emitting diodes
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Braune, Steffen
A1  - Gross, M.
A1  - Walter, M.
A1  - Zhou, Shengqiang
A1  - Dietze, Siegfried
A1  - Rutschow, S.
A1  - Lendlein, Andreas
A1  - Tschoepe, C.
A1  - Jung, Friedrich
T1  - Adhesion and activation of platelets from subjects with coronary artery disease and apparently healthy individuals on biomaterials
JF  - Journal of biomedical materials research : an official journal of the Society for Biomaterials, the Japanese Society for Biomaterials; the Australian Society for Biomaterials
N2  - On the basis of the clinical studies in patients with coronary artery disease (CAD) presenting an increased percentage of activated platelets, we hypothesized that hemocompatibility testing utilizing platelets from healthy individuals may result in an underestimation of the materials' thrombogenicity. Therefore, we investigated the interaction of polymer-based biomaterials with platelets from CAD patients in comparison to platelets from apparently healthy individuals. In vitro static thrombogenicity tests revealed that adherent platelet densities and total platelet covered areas were significantly increased for the low (polydimethylsiloxane, PDMS) and medium (Collagen) thrombogenic surfaces in the CAD group compared to the healthy subjects group. The area per single platelet—indicating the spreading and activation of the platelets—was markedly increased on PDMS treated with PRP from CAD subjects. This could not be observed for collagen or polytetrafluoroethylene (PTFE). For the latter material, platelet adhesion and surface coverage did not differ between the two groups. Irrespective of the substrate, the variability of these parameters was increased for CAD patients compared to healthy subjects. This indicates a higher reactivity of platelets from CAD patients compared to the healthy individuals. Our results revealed, for the first time, that utilizing platelets from apparently healthy donors bears the risk of underestimating the thrombogenicity of polymer-based biomaterials.
KW  - platelets
KW  - biomaterials
KW  - hemocompatibility
KW  - cardiovascular disease
KW  - cardiovascular implant
Y1  - 2016
U6  - https://doi.org/10.1002/jbm.b.33366
SN  - 1552-4973
SN  - 1552-4981
VL  - 104
SP  - 210
EP  - 217
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -