TY  - THES
A1  - Witt, Barbara
T1  - Toxicological characterization of lipid-soluble arsenic species in human brain cells
Y1  - 2017
ER  - 
TY  - JOUR
A1  - Ebert, Franziska
A1  - Ziemann, Vanessa
A1  - Wandt, Viktoria Klara Veronika
A1  - Witt, Barbara
A1  - Müller, Sandra Marie
A1  - Guttenberger, Nikolaus
A1  - Bankoglu, Ezgi Eyluel
A1  - Stopper, Helga
A1  - Raber, Georg
A1  - Francesconi, Kevin A.
A1  - Schwerdtle, Tanja
T1  - Cellular toxicological characterization of a thioxolated arsenic-containing hydrocarbon
JF  - Journal of trace elements in medicine and biology
N2  - Arsenolipids, especially arsenic-containing hydrocarbons (AsHC), are an emerging class of seafood originating contaminants. Here we toxicologically characterize a recently identified oxo-AsHC 332 metabolite, thioxo-AsHC 348 in cultured human liver (HepG2) cells. Compared to results of previous studies of the parent compound oxo-AsHC 332, thioxo-AsHC 348 substantially affected cell viability in the same concentration range but exerted about 10-fold lower cellular bioavailability. Similar to oxo-AsHC 332, thioxo-AsHC 348 did not substantially induce oxidative stress nor DNA damage. Moreover, in contrast to oxo-AsHC 332 mitochondria seem not to be a primary subcellular toxicity target for thioxo-AsHC 348. This study indicates that thioxo-AsHC 348 is at least as toxic as its parent compound oxo-AsHC 332 but very likely acts via a different mode of toxic action, which still needs to be identified.
Y1  - 2017
U6  - https://doi.org/10.1016/j.jtemb.2020.126563
VL  - 61
PB  - Elsevier
CY  - München
ER  -