TY  - GEN
A1  - Prinz, Julia
A1  - Heck, Christian
A1  - Ellerik, Lisa
A1  - Merk, Virginia
A1  - Bald, Ilko
T1  - DNA origami based Au–Ag-core–shell nanoparticle dimers with single-molecule SERS sensitivity
N2  - DNA origami nanostructures are a versatile tool to arrange metal nanostructures and other chemical entities with nanometer precision. In this way gold nanoparticle dimers with defined distance can be constructed, which can be exploited as novel substrates for surface enhanced Raman scattering (SERS). We have optimized the size, composition and arrangement of Au/Ag nanoparticles to create intense SERS hot spots, with Raman enhancement up to 1010, which is sufficient to detect single molecules by Raman scattering. This is demonstrated using single dye molecules (TAMRA and Cy3) placed into the center of the nanoparticle dimers. In conjunction with the DNA origami nanostructures novel SERS substrates are created, which can in the future be applied to the SERS analysis of more complex biomolecular targets, whose position and conformation within the SERS hot spot can be precisely controlled.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 221 
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-89714
SP  - 5612
EP  - 5620
ER  - 
TY  - JOUR
A1  - Prinz, Julia
A1  - Heck, Christian
A1  - Ellerik, Lisa
A1  - Merk, Virginia
A1  - Bald, Ilko
T1  - DNA origami based Au-Ag-core-shell nanoparticle dimers with single-molecule SERS sensitivity
JF  - Nanoscale
N2  - DNA origami nanostructures are a versatile tool to arrange metal nanostructures and other chemical entities with nanometer precision. In this way gold nanoparticle dimers with defined distance can be constructed, which can be exploited as novel substrates for surface enhanced Raman scattering (SERS). We have optimized the size, composition and arrangement of Au/Ag nanoparticles to create intense SERS hot spots, with Raman enhancement up to 10(10), which is sufficient to detect single molecules by Raman scattering. This is demonstrated using single dye molecules (TAMRA and Cy3) placed into the center of the nanoparticle dimers. In conjunction with the DNA origami nanostructures novel SERS substrates are created, which can in the future be applied to the SERS analysis of more complex biomolecular targets, whose position and conformation within the SERS hot spot can be precisely controlled.
Y1  - 2016
U6  - https://doi.org/10.1039/c5nr08674d
SN  - 2040-3364
SN  - 2040-3372
VL  - 8
SP  - 5612
EP  - 5620
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Prinz, Julia
A1  - Heck, Christian
A1  - Ellerik, Lisa
A1  - Merk, Virginia
A1  - Bald, Ilko
T1  - DNA origami based Au–Ag-core–shell nanoparticle dimers with single-molecule SERS sensitivity
JF  - Nanoscale
N2  - DNA origami nanostructures are a versatile tool to arrange metal nanostructures and other chemical entities with nanometer precision. In this way gold nanoparticle dimers with defined distance can be constructed, which can be exploited as novel substrates for surface enhanced Raman scattering (SERS). We have optimized the size, composition and arrangement of Au/Ag nanoparticles to create intense SERS hot spots, with Raman enhancement up to 1010, which is sufficient to detect single molecules by Raman scattering. This is demonstrated using single dye molecules (TAMRA and Cy3) placed into the center of the nanoparticle dimers. In conjunction with the DNA origami nanostructures novel SERS substrates are created, which can in the future be applied to the SERS analysis of more complex biomolecular targets, whose position and conformation within the SERS hot spot can be precisely controlled.
Y1  - 2016
U6  - https://doi.org/10.1039/C5NR08674D
IS  - 8
SP  - 5612
EP  - 5620
PB  - RSC Publishing
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Heck, Christian
A1  - Prinz, Julia
A1  - Dathe, Andre
A1  - Merk, Virginia
A1  - Stranik, Ondrej
A1  - Fritzsche, Wolfgang
A1  - Kneipp, Janina
A1  - Bald, Ilko
T1  - Gold Nanolenses Self-Assembled by DNA Origami
JF  - ACS Photonics
N2  - Nanolenses are self-similar chains of metal nanoparticles, which can theoretically provide extremely high field enhancements. Yet, the complex structure renders their synthesis challenging and has hampered closer analyses so far. Here, DNA origami is used to self-assemble 10, 20, and 60 nm gold nanoparticles as plasmonic gold nanolenses (AuNLs) in solution and in billions of copies. Three different geometrical arrangements are assembled, and for each of the three designs, surface-enhanced Raman scattering (SERS) capabilities of single AuNLs are assessed. For the design which shows the best properties, SERS signals from the two different internal gaps are compared by selectively placing probe dyes. The highest Raman enhancement is found for the gap between the small and medium nanoparticle, which is indicative of a cascaded field enhancement.
KW  - plasmonics
KW  - DNA origami
KW  - SERS
KW  - nanolenses
KW  - gold nanoparticles
Y1  - 2017
U6  - https://doi.org/10.1021/acsphotonics.6b00946
SN  - 2330-4022
VL  - 4
SP  - 1123
EP  - 1130
PB  - American Chemical Society
CY  - Washington
ER  -