TY  - JOUR
A1  - Saretia, Shivam
A1  - Machatschek, Rainhard Gabriel
A1  - Schulz, Burkhard
A1  - Lendlein, Andreas
T1  - Reversible 2D networks of oligo(epsilon-caprolactone) at the air-water interface
JF  - Biomedical Materials
N2  - Hydroxyl terminated oligo(epsilon-caprolactone) (OCL) monolayers were reversibly cross-linked forming two dimensional networks (2D) at the air-water interface. The equilibrium reaction with glyoxal as the cross-linker is pH-sensitive. Pronounced contraction in the area of the prepared 2DOCL films in dependence of surface pressure and time revealed the process of the reaction. Cross-linking inhibited crystallization and retarded enzymatic degradation of the OCLfilm. Altering the subphase pH led to a cleavage of the covalent acetal cross-links. The reversibility of the covalent acetal cross-links was proved by observing an identical isotherm as non-cross-linked sample. Besides as model systems, these customizable reversible OCL2D networks are intended for use as pHresponsive drug delivery systems or functionalized cell culture substrates.
KW  - poly(epsilon-caprolactone)
KW  - langmuir monolayer
KW  - two dimensional network
KW  - crystallization
KW  - cross-linking
Y1  - 2019
U6  - https://doi.org/10.1088/1748-605X/ab0cef
SN  - 1748-6041
SN  - 1748-605X
VL  - 14
IS  - 3
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  -