TY  - JOUR
A1  - Buchmann, Arlette F.
A1  - Hohm, Erika
A1  - Witt, Stephanie H.
A1  - Blomeyer, Dorothea
A1  - Jennen-Steinmetz, Christine
A1  - Schmidt, Martin H.
A1  - Esser, Günter
A1  - Banaschewski, Tobias
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - Role of CNR1 polymorphisms in moderating the effects of psychosocial adversity on impulsivity in adolescents
JF  - Journal of neural transmission
N2  - Enhanced endocannabinoid signaling has been implicated in typically adolescent behavioral features such as increased risk-taking, impulsivity and novelty seeking. Research investigating the impact of genetic variants in the cannabinoid receptor 1 gene (CNR1) and of early rearing conditions has demonstrated that both factors contribute to the prediction of impulsivity-related phenotypes. The present study aimed to test the hypothesis of an interaction of the two most studied CNR1 polymorphisms rs806379 and rs1049353 with early psychosocial adversity in terms of affecting impulsivity in 15-year-olds from an epidemiological cohort sample followed since birth. In 323 adolescents (170 girls, 153 boys), problems of impulse control and novelty seeking were assessed using parent-report and self-report, respectively. Exposure to early psychosocial adversity was determined in a parent interview conducted at the age of 3 months. The results indicated that impulsivity increased following exposure to early psychosocial adversity, with this increase being dependent on CNR1 genotype. In contrast, while individuals exposed to early adversity scored higher on novelty seeking, no significant impact of genotype or the interaction thereof was detected. This is the first evidence to suggest that the interaction of CNR1 gene variants with the experience of early life adversity may play a role in determining adolescent impulsive behavior. However, given that the reported findings are obtained in a high-risk community sample, results are restricted in terms of interpretation and generalization. Future research is needed to replicate these findings and to identify the mediating mechanisms underlying this effect.
KW  - CNR1
KW  - Impulsivity
KW  - Early psychosocial adversity
KW  - Adolescence
Y1  - 2015
U6  - https://doi.org/10.1007/s00702-014-1266-3
SN  - 0300-9564
SN  - 1435-1463
VL  - 122
IS  - 3
SP  - 455
EP  - 463
PB  - Springer
CY  - Wien
ER  - 
TY  - JOUR
A1  - Nikitopoulos, Joerg
A1  - Zohsel, Katrin
A1  - Blomeyer, Dorothea
A1  - Buchmann, Arlette F.
A1  - Schmid, Brigitte
A1  - Jennen-Steinmetz, Christine
A1  - Becker, Katja
A1  - Schmidt, Martin H.
A1  - Esser, Günter
A1  - Brandeis, Daniel
A1  - Banaschewski, Tobias
A1  - Laucht, Manfred
T1  - Are infants differentially sensitive to parenting? Early maternal care, DRD4 genotype and externalizing behavior during adolescence
JF  - Journal of psychiatric research
KW  - DRD4
KW  - Early maternal care
KW  - Externalizing behavior
KW  - Adolescence
KW  - Gene-environment interaction
Y1  - 2014
U6  - https://doi.org/10.1016/j.jpsychires.2014.08.012
SN  - 0022-3956
SN  - 1879-1379
VL  - 59
SP  - 53
EP  - 59
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Buchmann, Arlette F.
A1  - Blomeyer, Dorothea
A1  - Jennen-Steinmetz, Christine
A1  - Schmidt, Martin H.
A1  - Esser, Günter
A1  - Banaschewski, Tobias
A1  - Laucht, Manfred
T1  - Early smoking onset may promise initial pleasurable sensations and later addiction
JF  - Addiction biology
N2  - There is converging evidence suggesting a particular susceptibility to the addictive properties of nicotine among adolescents. The aim of the current study was to prospectively ascertain the relationship between age at first cigarette and initial smoking experiences, and to examine the combined effects of these characteristics of adolescent smoking behavior on adult smoking. It was hypothesized that the association between earlier age at first cigarette and later development of nicotine dependence may, at least in part, be attributable to differences in experiencing pleasurable early smoking sensations. Data were drawn from the participants of the Mannheim Study of Children at Risk, an ongoing epidemiological cohort study from birth to adulthood. Structured interviews at age 15, 19 and 22 years were conducted to assess the age at first cigarette, early smoking experiences and current smoking behavior in 213 young adults. In addition, the participants completed the Fagerstrom Test for Nicotine Dependence. Adolescents who smoked their first cigarette at an earlier age reported more pleasurable sensations from the cigarette, and they were more likely to be regular smokers at age 22. The age at first cigarette also predicted the number of cigarettes smoked and dependence at age 22. Thus, both the age of first cigarette and the pleasure experienced from the cigarette independently predicted aspects of smoking at age 22.
KW  - Adolescence
KW  - age at first cigarette
KW  - dependence
KW  - early smoking experiences
KW  - longitudinal study
KW  - pleasurable smoking sensations
Y1  - 2013
U6  - https://doi.org/10.1111/j.1369-1600.2011.00377.x
SN  - 1369-1600
VL  - 18
IS  - 6
SP  - 947
EP  - 954
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -