TY  - GEN
A1  - Wellenberg, Anna
A1  - Weides, L.
A1  - Bornhorst, Julia
A1  - Crone, Barbara
A1  - Karst, U.
A1  - Fritz, G.
A1  - Honnen, S.
T1  - Molecular and electrophysiological analysis of platinum-induced neurotoxicity using the model organism C. elegans
T2  - Naunyn-Schmiedeberg's archives of pharmacology
Y1  - 2019
UR  - https://link.springer.com/content/pdf/10.1007%2Fs00210-019-01621-6.pdf
U6  - https://doi.org/10.1007/s00210-019-01621-6
SN  - 0028-1298
SN  - 1432-1912
VL  - 392
SP  - S63
EP  - S63
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Aschner, Michael A.
A1  - Palinski, Catherine
A1  - Sperling, Michael
A1  - Karst, U.
A1  - Schwerdtle, Tanja
A1  - Bornhorst, Julia
T1  - Imaging metals in Caenorhabditis elegans
JF  - Metallomics : integrated biometal science
N2  - Systemic trafficking and storage of essential metal ions play fundamental roles in living organisms by serving as essential cofactors in various cellular processes. Thereby metal quantification and localization are critical steps in understanding metal homeostasis, and how their dyshomeostasis might contribute to disease etiology and the ensuing pathologies. Furthermore, the amount and distribution of metals in organisms can provide insight into their underlying mechanisms of toxicity and toxicokinetics. While in vivo studies on metal imaging in mammalian experimental animals are complex, time- and resource-consuming, the nematode Caenorhabditis elegans (C. elegans) provides a suitable comparative and complementary model system. Expressing homologous genes to those inherent to mammals, including those that regulate metal homeostasis and transport, C. elegans has become a powerful tool to study metal homeostasis and toxicity. A number of recent technical advances have been made in the development and application of analytical methods to visualize metal ions in C. elegans. Here, we briefly summarize key findings and challenges of the three main techniques and their application to the nematode, namely sensing fluorophores, microbeam synchrotron radiation X-ray fluorescence as well as laser ablation ( LA) coupled to inductively coupled plasma-mass spectrometry (ICP-MS).
Y1  - 2017
U6  - https://doi.org/10.1039/c6mt00265j
SN  - 1756-5901
SN  - 1756-591X
VL  - 9
SP  - 357
EP  - 364
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Honnen, S.
A1  - Wellenberg, Anna
A1  - Weides, L.
A1  - Bornhorst, Julia
A1  - Crone, B.
A1  - Karst, U.
A1  - Fritz, G.
T1  - Identification of potent drug candidates for the prevention of cisplatin-induced neurotoxicity in the model organism C. elegans
T2  - Naunyn-Schmiedeberg's archives of pharmacology
Y1  - 2018
UR  - https://link.springer.com/content/pdf/10.1007/s00210-018-1477-5.pdf
U6  - https://doi.org/10.1007/s00210-018-1477-5
SN  - 0028-1298
SN  - 1432-1912
VL  - 391
SP  - S4
EP  - S4
PB  - Springer
CY  - New York
ER  -