TY  - JOUR
A1  - Sarrar, Lea
A1  - Holzhausen, Martin
A1  - Warschburger, Petra
A1  - Pfeiffer, Ernst
A1  - Lehmkuhl, Ulrike
A1  - Schneider, Nora
T1  - Cognitive Function in Adolescent Patients with Anorexia Nervosa and Unipolar Affective Disorders
JF  - European eating disorders review : the professional journal of the Eating Disorders Associatio
N2  - Studies have shown impairments in cognitive function among adult patients with anorexia nervosa (AN) and affective disorders (AD). The association between cognitive dysfunctions, AN and AD as well as the specificity for these psychiatric diagnoses remains unclear. Therefore, we examined cognitive flexibility and processing speed in 47 female adolescent patients with AN, 21 female adolescent patients with unipolar affective disorders and 48 female healthy adolescents. All participants completed a neuropsychological test battery. There were no significant group differences regarding cognitive function, except for psychomotor processing speed with poorer performance in patients with AN. A further analysis revealed that all groups performed with the normal range, although patients with AN were over represented in the poorest performing quartile. We found no severe cognitive impairments in either patient group. Nevertheless, belonging to the AN group contributed significantly to poor performances in neuropsychological tasks. Therefore, we conclude that the risk for cognitive impairments is slightly higher for patients with AN. Copyright (c) 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
KW  - cognitive function
KW  - anorexia nervosa
KW  - unipolar affective disorders
KW  - adolescents
Y1  - 2016
U6  - https://doi.org/10.1002/erv.2425
SN  - 1072-4133
SN  - 1099-0968
VL  - 24
SP  - 232
EP  - 240
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Koch, Sabine
A1  - Titze, Karl
A1  - Zimmer, Ulrike
A1  - Lehmkuhl, Ulrike
A1  - Rauh, Hellgard
A1  - Helge, Hans
T1  - Growth of children exposed to antiepileptic medications in the womb
N2  - Antiepileptic drugs are suspected of being weakly teratogenic in humans. In a prospective longitudinal study, we assessed growth parameters of children from birth to adolescence who had been prenatally exposed to various antiepileptic drugs and compared them to non-exposed control children matched for parental body length, social status, and maternal nicotine consumption during pregnancy as well as for parity. While no differences in mean head circumferences could be ascertained in the group of exposed children at 1, 6, and 14 years, differences were measured in body length at I year. The differences were more pronounced for both measurements when therapy forms and types of drugs were considered: polytherapy and phenobarbitone therapy (which was usually part of polytherapy) of the mother appeared to have an influence on the children's growth. Children exposed to polytherapy and phenobarbitone (as single drug or as part of polytherapy) had smaller head circumferences and were shorter. We assume an influence of polytherapy and phenobarbitone therapy taken by the epileptic woman during pregnancy on the growth of the child into adolescence
Y1  - 2004
SN  - 0026-9298
ER  - 
TY  - JOUR
A1  - Koch, Sabine
A1  - Titze, Karl
A1  - Treuter, S.
A1  - Schröder, M.
A1  - Zimmermann, Ralf B.
A1  - Steinhausen, Hans-Christoph
A1  - Lehmkuhl, Ulrike
A1  - Rauh, Hellgard
T1  - Maternal use of valproate during pregnancy, risk of major malformations, and brain disorder
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Titze, Karl
A1  - Koch, Sabine
A1  - Helge, Hans
A1  - Lehmkuhl, Ulrike
A1  - Rauh, Hellgard
A1  - Steinhausen, Hans-Christoph
T1  - Prenatal and familial risks of children born by epileptic mothers : long term effects on the cognitive development
Y1  - 2008
UR  - http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2007.02020.x/pdf
U6  - https://doi.org/10.1111/j.1469-8749.2007.02020.x
ER  -