TY - JOUR A1 - Sarrar, L. A1 - Warschburger, Petra A1 - Pfeiffer, E. A1 - Lehmkuhl, Ulrike A1 - Schneider, N. T1 - Cognitive flexibility in adolescent patients with unipolar affective disorders - gender differences JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie N2 - Objective: Several studies have revealed impairments in cognitive functions among patients with affective disorders (AD). However, to date there are few neuropsychological studies on cognitive flexibility among adolescent patients with AD, especially on gender differences in AD. Here, we investigate cognitive functions, especially cognitive flexibility, in adolescent patients with unipolar AD (UAD) compared to a healthy control group (CG). Method: The study population consists of 17 male patients (M-age = 15.4 +/- 1.3) and 22 female patients with UAD (M-age = 15.6 +/- 1.4) as well as 20 male (M-age = 16.0 +/- 1.0) and 30 female (M-age = 15.7 +/- 0.9) healthy adolescents. A neuropsychological test battery was conducted, and depressive symptoms, psychological stress, and intelligence were also assessed. Results: The analyses revealed no significant group differences regarding cognitive flexibility or visual processing speed, albeit slight better performance in motor processing speed for the CG. Furthermore, no gender differences were observed regarding cognitive flexibility, though female subjects general displayed better performance in processing speed. Conclusions: Overall, there are no indications for serious deficits and specific gender differences in cognitive flexibility or processing speed in adolescent patients with UAD. Independent of psychological distress, female subjects seem to have some advantages in processing speed. KW - cognitive flexibility KW - unipolar affective disorders KW - sex differences KW - adolescents Y1 - 2013 U6 - https://doi.org/10.1024/1422-4917/a000240 SN - 1422-4917 VL - 41 IS - 4 SP - 261 EP - 270 PB - Hogrefe CY - Bern ER - TY - JOUR A1 - Sarrar, Lea A1 - Holzhausen, Martin A1 - Warschburger, Petra A1 - Pfeiffer, Ernst A1 - Lehmkuhl, Ulrike A1 - Schneider, Nora T1 - Cognitive Function in Adolescent Patients with Anorexia Nervosa and Unipolar Affective Disorders JF - European eating disorders review : the professional journal of the Eating Disorders Associatio N2 - Studies have shown impairments in cognitive function among adult patients with anorexia nervosa (AN) and affective disorders (AD). The association between cognitive dysfunctions, AN and AD as well as the specificity for these psychiatric diagnoses remains unclear. Therefore, we examined cognitive flexibility and processing speed in 47 female adolescent patients with AN, 21 female adolescent patients with unipolar affective disorders and 48 female healthy adolescents. All participants completed a neuropsychological test battery. There were no significant group differences regarding cognitive function, except for psychomotor processing speed with poorer performance in patients with AN. A further analysis revealed that all groups performed with the normal range, although patients with AN were over represented in the poorest performing quartile. We found no severe cognitive impairments in either patient group. Nevertheless, belonging to the AN group contributed significantly to poor performances in neuropsychological tasks. Therefore, we conclude that the risk for cognitive impairments is slightly higher for patients with AN. Copyright (c) 2015 John Wiley & Sons, Ltd and Eating Disorders Association. KW - cognitive function KW - anorexia nervosa KW - unipolar affective disorders KW - adolescents Y1 - 2016 U6 - https://doi.org/10.1002/erv.2425 SN - 1072-4133 SN - 1099-0968 VL - 24 SP - 232 EP - 240 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard T1 - Die Bedeutung entwicklungspsychologischer Modelle für die Kinder- und Jugendpsychiatrie Y1 - 1996 ER - TY - INPR A1 - Warschburger, Petra A1 - Lehmkuhl, Ulrike T1 - Disturbed eating behavior and its consequences T2 - Praxis der Kinderpsychologie und Kinderpsychiatrie : Ergebnisse aus Psychotherapie, Beratung und Psychiatrie Y1 - 2011 SN - 0032-7034 VL - 60 IS - 4 SP - 249 EP - 252 PB - Vandenhoeck & Ruprecht CY - Göttingen ER - TY - JOUR A1 - Koch, Sabine A1 - Titze, Karl A1 - Zimmer, Ulrike A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard A1 - Helge, Hans T1 - Growth of children exposed to antiepileptic medications in the womb N2 - Antiepileptic drugs are suspected of being weakly teratogenic in humans. In a prospective longitudinal study, we assessed growth parameters of children from birth to adolescence who had been prenatally exposed to various antiepileptic drugs and compared them to non-exposed control children matched for parental body length, social status, and maternal nicotine consumption during pregnancy as well as for parity. While no differences in mean head circumferences could be ascertained in the group of exposed children at 1, 6, and 14 years, differences were measured in body length at I year. The differences were more pronounced for both measurements when therapy forms and types of drugs were considered: polytherapy and phenobarbitone therapy (which was usually part of polytherapy) of the mother appeared to have an influence on the children's growth. Children exposed to polytherapy and phenobarbitone (as single drug or as part of polytherapy) had smaller head circumferences and were shorter. We assume an influence of polytherapy and phenobarbitone therapy taken by the epileptic woman during pregnancy on the growth of the child into adolescence Y1 - 2004 SN - 0026-9298 ER - TY - JOUR A1 - Koch, Sabine A1 - Titze, Karl A1 - Treuter, S. A1 - Schröder, M. A1 - Zimmermann, Ralf B. A1 - Steinhausen, Hans-Christoph A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard T1 - Maternal use of valproate during pregnancy, risk of major malformations, and brain disorder Y1 - 2000 ER - TY - JOUR A1 - Titze, Karl A1 - Koch, Sabine A1 - Helge, Hans A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard A1 - Steinhausen, Hans-Christoph T1 - Prenatal and familial risks of children born by epileptic mothers : long term effects on the cognitive development Y1 - 2008 UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2007.02020.x/pdf U6 - https://doi.org/10.1111/j.1469-8749.2007.02020.x ER - TY - JOUR A1 - Titze, Karl A1 - Koch, Sabine A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard T1 - Psychische und familiäre Risiken für Kinder von Frauen mit Epilepsie? : Ergebnisse einer Längsschnittstudie Y1 - 2007 ER - TY - JOUR A1 - Titze, Karl A1 - Koch, Sabine A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard T1 - Psychische und familäre Belastungen bei Kindern und Müttern mit Epilepsie Y1 - 2001 ER - TY - JOUR A1 - Titze, Karl A1 - Koch, Sabine A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard T1 - Soziofamiliäre und epilepsiespezifische Belastungen von Frauen mit Epilepsie Y1 - 2001 ER -