TY  - JOUR
A1  - Castellini, Alberto
A1  - Paltrinieri, Daniele
A1  - Manca, Vincenzo
T1  - MP-GeneticSynth: inferring biological network regulations from time series
JF  - Bioinformatics
N2  - MP-GeneticSynth is a Java tool for discovering the logic and regulation mechanisms responsible for observed biological dynamics in terms of finite difference recurrent equations. The software makes use of: (i) metabolic P systems as a modeling framework, (ii) an evolutionary approach to discover flux regulation functions as linear combinations of given primitive functions, (iii) a suitable reformulation of the least squares method to estimate function parameters considering simultaneously all the reactions involved in complex dynamics. The tool is available as a plugin for the virtual laboratory MetaPlab. It has graphical and interactive interfaces for data preparation, a priori knowledge integration, and flux regulator analysis.
Y1  - 2015
U6  - https://doi.org/10.1093/bioinformatics/btu694
SN  - 1367-4803
SN  - 1460-2059
VL  - 31
IS  - 5
SP  - 785
EP  - 787
PB  - Oxford Univ. Press
CY  - Oxford
ER  -