TY  - JOUR
A1  - Rudolph, Michael
A1  - Theile, M.
A1  - Frege, R.
A1  - Arnold, Wolfgang
A1  - Scherneck, Siegfried
T1  - Scanning electronmicroscopic investigations on cell revertants : suppression of tumorigenicity of breast cancer cells by transfer of normal human chromosome 17
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Rudolph, Michael
A1  - Theile, M.
A1  - Scherneck, S.
A1  - Arnold, Wolfgang
A1  - Scherneck, Siegfried
T1  - Suppression of tumorigenicity of breast cancer cells by transfer of normal human chromosome 17 - characterization of revertants : scanning electronmicroscopic investigations
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Jandrig, Burkhard
A1  - Seitz, Susanne
A1  - Hinzmann, Bernd
A1  - Arnold, Wolfgang
A1  - Micheel, Burkhard
A1  - Koelble, Konrad
A1  - Siebert, Reiner
A1  - Schwartz, Arnfried
A1  - Ruecker, Karin
A1  - Schlag, Peter M.
A1  - Scherneck, Siegfried
A1  - Rosenthal, Andra
T1  - ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2
N2  - We have identified a gene, ST18 (suppression of tumorigenicity 18, breast carcinoma, zinc-finger protein), within a frequent imbalanced region of chromosome 8q11 as a breast cancer tumor suppressor gene. The ST18 gene encodes a zinc-finger DNA-binding protein with six fingers of the C2HC type (configuration Cys-X5-Cys-X12-His-X4-Cys) and an SMC domain. ST18 has the potential to act as transcriptional regulator. ST18 is expressed in a number of normal tissues including mammary epithelial cells although the level of expression is quite low. In breast cancer cell lines and the majority of primary breast tumors, ST18 mRNA is significantly downregulated. A 160 bp region within the promoter of the ST18 gene is hypermethylated in about 80% of the breast cancer samples and in the majority of breast cancer cell lines. The strong correlation between ST18 promoter hypermethylation and loss of ST18 expression in tumor cells suggests that this epigenetic mechanism is responsible for tumor-specific downregulation. We further show that ectopic ST18 expression in MCF-7 breast cancer cells strongly inhibits colony formation in soft agar and the formation of tumors in a xenograft mouse model
Y1  - 2004
UR  - http://www.nature.com/cgi-taf/DynaPage.taf?file=/onc/journal/v23/n57/abs/ 1208131a.html&dynoptions=doi1113987275
ER  -