TY - GEN A1 - Hohm, Erika A1 - Zohsel, Katrin A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Beeinträchtigter Start ins Leben BT - Langfristige Auswirkungen der postpartalen Depression und der Einfluss des mütterlichen Interaktionsverhaltens T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Postpartale Depressionen sind häufige und schwerwiegende psychische Erkrankungen mit ungünstigem Einfluss auf die kindliche Entwicklung. Als Haupttransmissionsweg gilt die frühe Mutter-Kind-Interaktion. Über die langfristigen Auswirkungen auf die Kinder im Erwachsenenalter und die Rolle der Interaktion liegen kaum Ergebnisse vor. Im Rahmen der Mannheimer Risikokinderstudie wurden postpartale Depressionen bis zwei Jahre nach der Geburt erfasst. Die kindliche Entwicklung wurde fortlaufend und die Mutter-Kind-Interaktion im Alter von 3 Monaten standardisiert erhoben. 28 Kinder postpartal depressiver und 107 Kinder gesunder Mütter konnten mit 25 Jahren untersucht werden. Beeinträchtigungen der kognitiven und psychischen Entwicklung bei Kindern postpartal depressiver Mütter waren bis ins Erwachsenenalter nachweisbar. Responsives bzw. sensitives mütterliches Verhalten wirkte der negativen Entwicklung entgegen. Dies betont die Bedeutung einer hohen Qualität der Mutter-Kind-Interaktion für die Entwicklung von Risikokindern. N2 - Postpartum depression (PPD) is a common and serious mental health problem with prevalence rates ranging from 13 % to 19 %, and is associated with an increased risk of adverse child development. PPD is characterized by symptoms common of depression, particularly by impairments of maternity, parenting, and mother–infant interactions. Several reviews suggest an impact on attachment, cognitive, behavioral, and health-related outcome in the offspring. However, the long-term effects of PPD regarding cognitive and mental development into adulthood and the underlying mechanisms, especially the role of maternal interactional behavior, are not yet well understood. In the Mannheim Study of Children at Risk, maternal depression was assessed when the child was 3 months and 2 years old. Development from infancy to young adulthood (25 years) was assessed at regular intervals in 28 children of postnatally depressed mothers and 107 children born to mentally healthy mothers. Cognitive outcome up to age 11 was measured using standardized instruments; in adulthood, school outcome was used approximately. Psychiatric diagnosis as well as symptom scores served as psychological outcome. At age 3 months, mothers and infants were videotaped during a nursing and a playing situation. Videotapes of the 10-min session were recorded and evaluated by trained raters (κ > .83) using the Category System for Microanalysis of Early Mother Child Interaction (Esser, Scheven, et al., 1989). The cognitive as well as social–emotional outcome of children of mothers suffering from PPD was significantly poorer than in the children of mentally healthy mothers. The adverse effects were more pronounced during childhood. The offspring of postnatally depressed mothers who interacted in a responsive manner with their infant exhibited a better prognosis in contrast to those with mothers interacting less sensitively. This effect was observed with regard to cognitive development and symptoms of externalizing behavior at age 19 years. Regarding internalizing behavior, no impact of maternal behavior was detected. These findings emphasize the importance of high-quality early mother–child interaction in the development of children at risk. Furthermore, convincing arguments are given for very early specialized treatment of impaired mother–child interactions in mothers suffering from PPD. The PPD treatment should always comprise treatment of depression as well as treatment of the disturbed mother–child interaction. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 692 KW - Postpartale Depression KW - Entwicklung KW - Längsschnittstudie KW - Mannheimer Risikokinderstudie KW - Mutter-Kind-Interaktion KW - postpartum depression KW - development KW - longitudinal study KW - Mannheim Study of Children at Risk KW - mother–child interaction Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433406 SN - 1866-8364 IS - 692 ER - TY - GEN A1 - Zohsel, Katrin A1 - Hohm, Erika A1 - Schmidt, Martin H. A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Die langfristigen Auswirkungen von Frühgeburtlichkeit auf kognitive Entwicklung und Schulerfolg T1 - Long-term consequences of preterm birth on cognitive development and academic achievement BT - Gibt es einen protektiven Effekt mütterlicher Responsivität? BT - Is there a protective effect of maternal responsiveness? T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - In einer prospektiven Längsschnittstudie wurde der Zusammenhang zwischen früher Responsivität der Mutter und kognitiver Entwicklung ihrer früh- bzw. reifgeborenen Kinder untersucht. Im Alter von drei Monaten wurde dafür die Mutter-Kind-Interaktion mittels Verhaltensbeobachtung erfasst. Bei n=351 der teilnehmenden Kinder (101 frühgeboren) wurde die allgemeine Intelligenz (IQ) im Alter von 11 Jahren und bei n=313 (85 frühgeboren) zusätzlich der höchste erreichte Schulabschluss bis 25 Jahren erhoben. Frühgeborene wiesen mit 11 Jahren einen signifikant niedrigeren IQ als Reifgeborene auf, nachdem für mögliche konfundierende Faktoren kontrolliert worden war. Nur bei Früh-, nicht aber bei Reifgeborenen zeigte sich ein signifikanter positiver Zusammenhang zwischen mütterlicher Responsivität und IQ. Für die Wahrscheinlichkeit einen höheren Schulabschluss (mind. Fachabitur) zu erreichen, fand sich weder ein signifikanter Effekt von Frühgeburtlichkeit noch von mütterlicher Responsivität. N2 - Preterm birth is associated with adverse long-term consequences regarding cognitive development. Whereas children born very preterm represent a subgroup at special risk, also so-called “late preterms” are affected to a lesser degree. Effects of prematurity can be observed until adulthood. For example, decreased wealth was reported in adults born preterm, which was mediated by decreased intelligence during childhood and lower educational qualifications during young adulthood. Hence, it is highly relevant to examine whether certain factors can buffer against the adverse effects of preterm birth on cognitive development. Parenting might play an important role here. There is evidence suggesting a protective effect of sensitive parenting during childhood on later cognitive outcome in preterms. In the current study, we examined whether early responsive maternal care was associated with later intelligence and academic achievement in children born preterm versus fullterm. As part of an ongoing cohort study, early maternal responsiveness was assessed at the child's age of 3 months (adjusted for gestational age) during a nursing and playing situation. At age 11 years, general intelligence (IQ) was determined in n=351 children (101 born preterm; 168 male). Until age 25 years, educational qualification was assessed in n=313 participants (85 born preterm; 145 male). IQ at age 11 was significantly lower in preterms compared to fullterms after adjusting for potential confounders like maternal educational background and early psychosocial risk. A significant interaction between preterm birth and early maternal responsiveness was detected. In preterms only, higher levels of early maternal responsiveness were significantly associated with higher child IQ. Lower IQs in children born preterm as compared to fullterm were observed in the subaverage to average range of maternal responsiveness. Interestingly, preterms exposed to very high levels of maternal responsiveness showed slightly higher IQs when compared to children born at term. With regard to academic achievement, neither a significant effect of preterm birth nor of early maternal responsiveness occurred after adjusting for potential confounders. The results of the current study replicate and extend earlier findings with regard to a protective effect of sensitive parenting on childhood cognitive outcome in preterms. The lacking impact of prematurity on academic achievement may be explained by the exclusion of participants with IQs outside the normal range in the current study. Interventions enhancing early responsive care in parents of preterms may be advisable. More studies on long-term outcomes of such interventions on cognitive development are encouraged. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 701 KW - Frühgeburt KW - Elternverhalten KW - kognitive Entwicklung KW - Längsschnittstudie KW - Mannheimer Risikokinderstudie KW - preterm birth KW - parental quality KW - cognitive development KW - longitudinal study KW - Mannheim Study of Children at Risk Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433536 SN - 1866-8364 IS - 701 ER - TY - GEN A1 - Kaminski, Jakob A. A1 - Schlagenhauf, Florian A1 - Rapp, Michael Armin A1 - Awasthi, Swapnil A1 - Ruggeri, Barbara A1 - Deserno, Lorenz A1 - Banaschewski, Tobias A1 - Bokde, Arun L. W. A1 - Bromberg, Uli A1 - Büchel, Christian A1 - Quinlan, Erin Burke A1 - Desrivières, Sylvane A1 - Flor, Herta A1 - Frouin, Vincent A1 - Garavan, Hugh A1 - Gowland, Penny A1 - Ittermann, Bernd A1 - Martinot, Jean-Luc A1 - Paillère Martinot, Marie-Laure A1 - Nees, Frauke A1 - Papadopoulos Orfanos, Dimitri A1 - Paus, Tomáš A1 - Poustka, Luise A1 - Smolka, Michael N. A1 - Fröhner, Juliane H. A1 - Walter, Henrik A1 - Whelan, Robert A1 - Ripke, Stephan A1 - Schumann, Gunter A1 - Heinz, Andreas T1 - Epigenetic variance in dopamine D2 receptor BT - a marker of IQ malleability? T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 950 KW - genome-wide association KW - reward anticipation KW - human intelligence KW - human brain KW - stress KW - metaanalysis KW - striatum KW - psychopathology KW - prediction KW - volume KW - epigenetics and behaviour KW - human behaviour KW - learning and memory Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-425687 SN - 1866-8372 IS - 950 ER - TY - GEN A1 - Zohsel, Katrin A1 - Hohm, Erika A1 - Schmidt, Martin H. A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Langfristige Folgen früher psychosozialer Risiken T1 - Long-term consequences of early psychosocial risks BT - Child Behavior Checklist-Dysregulationsprofil als vermittelnder Faktor BT - a mediating role of the Child Behavior Checklist-Dysregulation Profile T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - In einer prospektiven Längsschnittstudie wurden Auswirkungen früher psychosozialer Risiken bis ins junge Erwachsenenalter untersucht und dabei die Rolle von affektiver und behavioraler Dysregulation im Kindesalter als vermittelndem Faktor überprüft. Drei Monate nach der Geburt wurde das Vorliegen von 11 psychosozialen Belastungsfaktoren erfasst. Im Alter von 8 – 15 Jahren wurde dreimal das Child Behavior Checklist-Dysregulationsprofil (CBCL-DP) erhoben. Mit 25 Jahren wurde ein Strukturiertes Klinisches Interview durchgeführt und 309 der Teilnehmer füllten den Young Adult Self-Report aus. Frühe psychosoziale Risiken gingen mit einem erhöhten Risiko für das Vorliegen eines Substanzmissbrauchs im jungen Erwachsenenalter sowie mit erhöhtem externalisierendem und internalisierendem Problemverhalten einher. Der Zusammenhang zwischen frühen psychosozialen Risiken und späterem externalisierendem bzw. internalisierendem Problemverhalten wurde durch das CBCL-DP vermittelt. N2 - Numerous studies suggested an association between childhood adversities and later increased risk for mental illness. However, most studies have used adults’ retrospective self-reports for assessing adverse childhood experiences. Mechanisms underlying the association between childhood adversities and later psychopathology are not yet well understood. In the Mannheim Study of Children at Risk, we prospectively examined the impact of early psychosocial risks on psychopathology in early adulthood. In addition, we tested the mediating role of childhood affective and behavioral dysregulation. In a total of 384 infants from the Rhine-Neckar region of Germany born between 1986 and 1988, the presence of 11 adverse family factors was assessed by use of a standardized parent interview conducted when the child was 3 months old. At the child’s age of 8, 11, and 15 years, parents completed the Child Behavior Checklist (CBCL). The CBCL-Dysregulation Profile (CBCL-DP) was formed by summing up the scores of the syndrome scales of aggressive, inattentive, and anxious/depressed behavior. At the age of 25 years, the Structured Clinical Interview for DSM-IV (SCID) was conducted with n = 307 participants to obtain psychiatric diagnoses for the period of young adulthood. In addition, 309 participants filled out the Young Adult Self-Report (YASR) to assess current externalizing and internalizing problem behavior. With respect to psychiatric diagnoses during young adulthood, early psychosocial risks were associated with a significantly increased probability for suffering from substance abuse/dependence. By contrast, risk was not significantly increased for anxiety, depressive, and personality disorders. In addition, early psychosocial risks significantly predicted externalizing and internalizing behavior problems as measured by the YASR. The CBCL-DP was found to mediate this association. To conclude, our results confirm an association between childhood adversities and psychopathology in adulthood. Hence, findings from retrospective studies can also be replicated by the use of prospective study designs. Affective and behavioral dysregulation as measured by the CBCL-DP seems to be a mediating bridge between early psychosocial risks and long-term adverse consequences. The CBCL-DP may be used to identify children at an enhanced risk for developing chronic mental problems. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 609 KW - Psychosoziales Risiko KW - Längsschnittstudie KW - Mannheimer Risikokinderstudie KW - Child Behavior Checklist-Dysregulationsprofil KW - early adversity KW - longitudinal study KW - Mannheim Study of Children at Risk KW - Child Behavior Checklist-Dysregulation Profile Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433424 SN - 1866-8364 IS - 609 SP - 203 EP - 209 ER - TY - GEN A1 - Hohm, Erika A1 - Laucht, Manfred A1 - Zohsel, Katrin A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Banaschewski, Tobias T1 - Resilienz und Ressourcen im Verlauf der Entwicklung BT - von der frühen Kindheit bis zum Erwachsenenalter T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Anhand von Daten der Mannheimer Risikokinderstudie, die sich mit der langfristigen Entwicklung von Kindern mit unterschiedlichen Risikobelastungen beschäftigt, wird gezeigt, wie Schutzfaktoren aufseiten des Kindes und seines familiären Umfelds im Verlauf der Entwicklung wirksam werden und zur Entstehung von Resilienz beitragen können. Eine besondere Rolle kommt dabei positiven frühen Eltern-Kind-Beziehungen zu (sowohl Mutter- als auch Vater-Kind-Interaktionen). Daneben spielen auch Interaktionserfahrungen im Alter von zwei Jahren des Kindes eine bedeutsame Rolle; diese schützen Risikokinder davor, eine ungünstige Entwicklung zu nehmen und tragen dazu bei, dass sich Kinder, die in psychosozialen Hochrisikofamilien aufwachsen, trotz ungünstiger „Startbedingungen“ positiv entwickeln. Neben Merkmalen der sozialen Umwelt nehmen auch sprachliche, sozial-emotionale und internale Kompetenzen des Kindes im Entwicklungsverlauf eine wichtige Rolle ein. Diese Kompetenzen ermöglichen es Risikokindern auch unter widrigen Lebensumständen (psychosoziale Hochrisikofamilien, Aufwachsen in Armutsverhältnissen) erfolgreich zu bestehen. Darüber hinaus zeigt die Arbeit, dass Resilienz ein Persönlichkeitsmerkmal ist, das ab dem frühen Erwachsenenalter eine hohe Stabilität besitzt. Mit diesen Befunden verweist die Arbeit auf die große Bedeutung der Resilienz bei der Vorhersage der langfristigen Entwicklung von Risikokindern. N2 - Resilience refers to the ability to successfully deal with stressful life circumstances and experiences and to cope with them. Based on data from the Mannheim Study of Children at Risk, which follows a sample of children at risk from birth to adulthood, the present paper provides convincing evidence demonstrating how protective factors in the child and his/her family environment operate during the course of development to contribute to the development of resilience. As shown, a major role is assigned to positive early parent–child relationships (both mother– and father–child interactions). Moreover, positive interactive experiences at the child’s age of 2 years play a significant role. These experiences consistently contribute to a positive child development in the face of adversity. In addition to characteristics of the social environment of the child, cognitive, social–emotional, and internal competencies during childhood, youth, and young adulthood play a major role in the development of resilience. These competencies enable children at risk who are growing up in psychosocial high-risk families or in poverty to successfully cope with conditions of high adversity. Moreover, the findings presented here demonstrate that resilience may be conceived as a personal characteristic that exhibits high stability since young adulthood. With these findings, the present study points to the significance of resilience in predicting the long-term outcome of children at risk. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 608 KW - Schutzfaktoren KW - Risikofaktoren KW - Längsschnittstudie KW - Mannheimer Risikokinderstudie KW - frühe Eltern-Kind-Beziehung KW - protective factors KW - risk factors KW - longitudinal study KW - Mannheim Study of Children at Risk KW - early parent-child relationship Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433072 SN - 1866-8364 IS - 608 SP - 230 EP - 239 ER - TY - GEN A1 - Xie, Chao A1 - Jia, Tianye A1 - Rolls, Edmund T. A1 - Robbins, Trevor W. A1 - Sahakian, Barbara J. A1 - Zhang, Jie A1 - Liu, Zhaowen A1 - Cheng, Wei A1 - Luo, Qiang A1 - Zac Lo, Chun-Yi A1 - Schumann, Gunter A1 - Feng, Jianfeng A1 - Wang, He A1 - Banaschewski, Tobias A1 - Barker, Gareth J. A1 - Bokde, Arun L.W. A1 - Büchel, Christian A1 - Quinlan, Erin Burke A1 - Desrivières, Sylvane A1 - Flor, Herta A1 - Grigis, Antoine A1 - Garavan, Hugh A1 - Gowland, Penny A1 - Heinz, Andreas A1 - Hohmann, Sarah A1 - Ittermann, Bernd A1 - Martinot, Jean-Luc A1 - Paillère Martinot, Marie-Laure A1 - Nees, Frauke A1 - Papadopoulos Orfanos, Dimitri A1 - Paus, Tomáš A1 - Poustka, Luise A1 - Fröhner, Juliane H. A1 - Smolka, Michael N. A1 - Walter, Henrik A1 - Whelan, Robert T1 - Reward versus nonreward sensitivity of the medial versus lateral orbitofrontal cortex relates to the severity of depressive symptoms T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - BACKGROUND: The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms. METHODS: Activations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14. RESULTS: The medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003). CONCLUSIONS: Activations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 860 KW - adolescents KW - depression KW - monetary incentive delay task KW - nonreward sensitivity KW - orbitofrontal cortex KW - reward anticipation KW - reward sensitivity KW - ventral striatum Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-557882 SN - 1866-8364 IS - 3 ER -