TY  - JOUR
A1  - Salama, Ahmed
A1  - Neumann, Mike
A1  - Günter, Christina
A1  - Taubert, Andreas
T1  - Ionic liquid-assisted formation of cellulose/calcium phosphate hybrid materials
JF  - Beilstein journal of nanotechnology
N2  - Cellulose/calcium phosphate hybrid materials were synthesized via an ionic liquid-assisted route. Scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis/differential thermal analysis show that, depending on the reaction conditions, cellulose/hydroxyapatite, cellulose/ chlorapatite, or cellulose/monetite composites form. Preliminary studies with MC3T3-E1 pre-osteoblasts show that the cells proliferate on the hybrid materials suggesting that the ionic liquid-based process yields materials that are potentially useful as scaffolds for regenerative therapies.
KW  - biomineralization
KW  - calcium phosphate
KW  - carbohydrates
KW  - cellulose
KW  - hybrid materials
KW  - ionic liquid
Y1  - 2014
U6  - https://doi.org/10.3762/bjnano.5.167
SN  - 2190-4286
VL  - 5
SP  - 1553
EP  - 1568
PB  - Beilstein-Institut zur Förderung der Chemischen Wissenschaften
CY  - Frankfurt, Main
ER  - 
TY  - JOUR
A1  - Hardy, John G.
A1  - Torres-Rendon, Jose Guillermo
A1  - Leal-Egana, Aldo
A1  - Walther, Andreas
A1  - Schlaad, Helmut
A1  - Coelfen, Helmut
A1  - Scheibel, Thomas R.
T1  - Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering
JF  - Materials
N2  - Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.
KW  - spider silk
KW  - recombinant protein
KW  - biodegradable polymers
KW  - biomaterials
KW  - biomineralization
KW  - bone tissue engineering
Y1  - 2016
U6  - https://doi.org/10.3390/ma9070560
SN  - 1996-1944
VL  - 9
SP  - 93
EP  - 108
PB  - MDPI
CY  - Basel
ER  -