TY  - JOUR
A1  - Steuer, Ralf
A1  - Kurths, Jürgen
A1  - Fiehn, Oliver
A1  - Weckwerth, Wolfram
T1  - Interpreting correlations in metabolomic networks
N2  - Correlations, as observed between the concentrations of metabolites in a biological sample, may be used to gain additional information about the physiological state of a given tissue. in this mini-review, we discuss the integration of these observed correlations into metabolomic networks and their relationships with the underlying biochemical pathways
Y1  - 2003
SN  - 0300-5127
ER  - 
TY  - JOUR
A1  - Steuer, Ralf
A1  - Zhou, Changsong
A1  - Kurths, Jürgen
T1  - Constructive effects of fluctuations in genetic and biochemical regulatory systems
N2  - Biochemical and genetic regulatory systems that involve low concentrations of molecules are inherently noisy. This intrinsic stochasticity, has received considerable interest recently, leading to new insights about the sources and consequences of noise in complex systems of genetic regulation. However, most prior work was devoted to the reduction of fluctuation and the robustness of cellular function with respect to intrinsic noise. Here, we focus on several scenarios in which the inherent molecular fluctuations are not merely a nuisance, but act constructively and bring about qualitative changes in the dynamics of the system. It will be demonstrated that in many typical situations biochemical and genetic regulatory systems may utilize intrinsic noise to their advantage. (C) 2002 Elsevier Ireland Ltd. All rights reserved
Y1  - 2003
SN  - 0303-2647
ER  -