TY  - JOUR
A1  - Heringer-Walther, Silvia
A1  - Moreira, Maria da Consolacao V.
A1  - Wessel, Niels
A1  - Wang, Yong
A1  - Ventura, Pago Moreira
A1  - Schultheiss, Heinz-Peter
A1  - Walther, Thomas
T1  - Does the C-type natriuretic peptide have prognostic value in Chagas disease and other dilated cardiomyopathies
JF  - Journal of cardiovascular pharmacology
N2  - Atrial natriuretic peptides (ANP) and brain natriuretic peptides (BNP) are powerful neurohormonal indicators of left-ventricular function and prognosis in heart failure (HF). Chagas disease (CD) caused by the protozoan Trypanosoma cruzi. remains a major cause of HF in Latin America. We assessed whether the plasma concentration of the third natriuretic peptide, C-type natnuretic peptide (CNP), also has diagnostic and prognostic properties in patients with CD or other dilated cardiomyopathies (DCM). Blood samples were obtained from 66 patients with CD, 50 patients with DCM from other causes, and 30 gender- and age-matched healthy subjects. Patients were subdivided according to the New York Heart Association (NYHA) class. The CNP concentration was determined by radioimmunoassay (Immundiagnostik, Bensheim, Germany). The main duration of follow-up was 31.4 months (range 13 to 54 months), 19 patients had died and 11 patients received a heart transplant. CNP concentrations were only significantly altered in patients with DCM or CD of the NYHA classes III and IV (P < 0.05). The Pearson correlation of echocardiographic data with CNP revealed an association only with the left-ventricular end systolic volume (P = 0.03) in patients with DCM. Furthermore, CNP did not predict mortality or the necessity for heart transplant. Our data are the first to demonstrate the raised levels of the third natriuretic peptide CNP in CD and other DCM Whereas ANP and BNP have a high predictive value for mortality in both diseases, CNP is without any predictive potency.
KW  - cardiomyopathy
KW  - heart failure
KW  - natriuretic peptide system
KW  - Trypanosoma cruzi
Y1  - 2006
U6  - https://doi.org/10.1097/01.fjc.0000249892.22635.46
SN  - 0160-2446
VL  - 48
IS  - 6
SP  - 293
EP  - 298
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  -