TY  - JOUR
A1  - Akampurira, Denis
A1  - Akala, Hoseah M.
A1  - Derese, Solomon
A1  - Heydenreich, Matthias
A1  - Yenesew, Abiy
T1  - A new C-C linked benzophenathridine-2-quinoline dimer, and the antiplasmodial activity of alkaloids from Zanthoxylum holstzianum
JF  - Natural product research
N2  - The CH2Cl2/MeOH (1:1) extract of Zanthoxylum holstzianum stem bark showed good antiplasmodial activity (IC50 2.5 +/- 0.3 and 2.6 +/- 0.3 mu g/mL against the W2 and D6 strains of Plasmodium falciparum, respectively). From the extract five benzophenanthridine alkaloids [8-acetonyldihydrochelerythrine (1), nitidine (2), dihydrochelerythine (3), norchelerythrine (5), arnottianamide (8)]; a 2-quinolone alkaloid [N-methylflindersine (4)]; a lignan [4,4 '-dihydroxy-3,3 '-dimethoxylignan-9,9 '-diyl diacetate (7)] and a dimer of a benzophenanthridine and 2-quinoline [holstzianoquinoline (6)] were isolated. The CH2Cl2/MeOH (1:1) extract of the root bark afforded 1, 3-6, 8, chelerythridimerine (9) and 9-demethyloxychelerythrine (10). Holstzianoquinoline (6) is new, and is the second dimer linked by a C-C bond of a benzophenanthridine and a 2-quinoline reported thus far. The compounds were identified based on spectroscopic evidence. Amongst five compounds (1-5) tested against two strains of P. falciparum, nitidine (IC50 0.11 +/- 0.01 mu g/mL against W2 and D6 strains) and norchelerythrine (IC50 value of 0.15 +/- 0.01 mu g/mL against D6 strain) were the most active.
KW  - Antiplasmodial
KW  - benzophenanthridine alkaloid
KW  - holstzianoquinoline;
KW  - rutaceae
KW  - Zanthoxylum holstzianum
Y1  - 2022
U6  - https://doi.org/10.1080/14786419.2022.2034810
SN  - 1478-6419
SN  - 1478-6427
VL  - 37
IS  - 13
SP  - 2161
EP  - 2171
PB  - Taylor & Francis
CY  - London [u.a.]
ER  - 
TY  - JOUR
A1  - Andayi, Andrew W.
A1  - Yenesew, Abiy
A1  - Derese, Solomon
A1  - Midiwo, Jacob O.
A1  - Gitu, Peter M.
A1  - Jondiko, Ogoche J. I.
A1  - Akala, Hoseah M.
A1  - Liyala, Pamela
A1  - Wangui, Julia
A1  - Waters, Norman C.
A1  - Heydenreich, Matthias
A1  - Peter, Martin G.
T1  - Antiplasmodial flavonoids from Erythrina sacleuxii
N2  - The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'- prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence
Y1  - 2006
UR  - http://www.thieme-connect.com/ejournals/toc/plantamedica
U6  - https://doi.org/10.1055/s-2005-873200
SN  - 0032-0943
ER  - 
TY  - JOUR
A1  - Buyinza, Daniel
A1  - Derese, Solomon
A1  - Ndakala, Albert
A1  - Heydenreich, Matthias
A1  - Yenesew, Abiy
A1  - Koch, Andreas
A1  - Oriko, Richard
T1  - A coumestan and a coumaronochromone from Millettia lasiantha
JF  - Biochemical systematics and ecology
N2  - The manuscript describes the phytochemical investigation of the roots, leaves and stem bark of Millettia lasiantha resulting in the isolation of twelve compounds including two new isomeric isoflavones lascoumestan and las-coumaronochromone. The structures of the new compounds were determined using different spectroscopic techniques.
KW  - Millettia lasiantha
KW  - Leguminosae
KW  - Coumestan
KW  - Coumaronochromone
Y1  - 2021
U6  - https://doi.org/10.1016/j.bse.2021.104277
SN  - 0305-1978
SN  - 1873-2925
VL  - 97
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Chepkirui, Carolyne
A1  - Ochieng, Purity J.
A1  - Sarkar, Biswajyoti
A1  - Hussain, Aabid
A1  - Pal, Chiranjib
A1  - Yang, Li Jun
A1  - Coghi, Paolo
A1  - Akala, Hoseah M.
A1  - Derese, Solomon
A1  - Ndakala, Albert
A1  - Heydenreich, Matthias
A1  - Wong, Vincent K. W.
A1  - Erdelyi, Mate
A1  - Yenesew, Abiy
T1  - Antiplasmodial and antileishmanial flavonoids from Mundulea sericea
JF  - Fitoterapia
N2  - Five known compounds (1-5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6-8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 mu M against chloroquine-resistant W2, and 6.6 mu M against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 mu M, respectively. In a cytotoxicity assay, lupinifolin (3) showed significant activity on BEAS-2B (IC50 4.9 mu M) and HePG2 (IC50 10.8 mu M) human cell lines. All the other compounds showed low cytotoxicity (IC50 > 30 mu M) against human lung adenocarcinoma cells (A549), human liver cancer cells (HepG2), lung/bronchus cells (epithelial virus transformed) (BEAS-2B) and immortal human hepatocytes (LO2)
KW  - Mundulea sericea
KW  - leguminosae
KW  - flavanonol
KW  - flavonol
KW  - antiplasmodial
KW  - antileishmanial
KW  - cytotoxicity
Y1  - 2020
U6  - https://doi.org/10.1016/j.fitote.2020.104796
SN  - 0367-326X
SN  - 1873-6971
VL  - 149
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Derese, Solomon
A1  - Barasa, Leonard
A1  - Akala, Hoseah M.
A1  - Yusuf, Amir O.
A1  - Kamau, Edwin
A1  - Heydenreich, Matthias
A1  - Yenesew, Abiy
T1  - 4 '-Prenyloxyderrone from the stem bark of Millettia oblata ssp  teitensis and the antiplasmodial activities of isoflavones from some Millettia species
JF  - Phytochemistry letters
N2  - The CH2Cl2/MeOH (1: 1) extract of the stem bark of Millettia oblata ssp. teitensis showed antiplasmodial activity (IC50 = 10-12 mu g/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the isolation of a new isoflavone, 4'-prenyloxyderrone (1), together with known isoflavones (8-O-methylretusin, durmillone, maximaisoflavone B, maximaisoflavone H and maximaisoflavone J), a rotenoid (tephrosin) and a triterpene (lupeol). Similar investigation of Millettia leucantha resulted in the identification of the isoflavones afrormosin and wistin, and the flavone chrysin. The identification of these compounds was based on their spectroscopic data. Five of the isoflavones isolated from these plants as well as 11 previously reported compounds from Millettia dura were tested and showed good to moderate antiplasmodial activities (IC50 = 13-53 mu M), with the new compound, 4'-prenyloxyderrone, being the most active (IC50 = 13-15 mu M).
KW  - Millettia oblata ssp teitensis
KW  - Millettia leucantha
KW  - Millettia dura;
Y1  - 2014
U6  - https://doi.org/10.1016/j.phytol.2014.02.001
SN  - 1874-3900
SN  - 1876-7486
VL  - 8
SP  - 69
EP  - 72
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - THES
A1  - Derese, Solomon
A1  - Yenesew, Abiy
A1  - Midiwo, Jacob O.
A1  - Heydenreich, Matthias
A1  - Peter, Martin G.
T1  - A new isoflavone from stem bark of Millettia dura
Y1  - 2003
SN  - 1011-3924
ER  - 
TY  - JOUR
A1  - Deyou, Tsegaye
A1  - Marco, Makungu
A1  - Heydenreich, Matthias
A1  - Pan, Fangfang
A1  - Gruhonjic, Amra
A1  - Fitzpatrick, Paul A.
A1  - Koch, Andreas
A1  - Derese, Solomon
A1  - Pelletier, Jerry
A1  - Rissanen, Kari
A1  - Yenesew, Abiy
A1  - Erdelyi, Mate
T1  - Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp teitensis
JF  - Journal of natural products
N2  - A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 mu M, respectively.
Y1  - 2017
U6  - https://doi.org/10.1021/acs.jnatprod.7b00255
SN  - 0163-3864
SN  - 1520-6025
VL  - 80
SP  - 2060
EP  - 2066
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Gumula, Ivan
A1  - Heydenreich, Matthias
A1  - Derese, Solomon
A1  - Ndiege, Isaiah O.
A1  - Yenesew, Abiy
T1  - Four isoflavanones from the stem bark of Platycelphium voense
JF  - Phytochemistry letters
N2  - From the stem bark of Platycelphium voense (Leguminosae) four new isoflavanones were isolated and characterized as (S)-5,7-dihydroxy-2 ',4 '-dimethoxy-3 '-(3 ''-methylbut-2 ''-enyl)-isoflavanone (trivial name platyisoflavanone A), (+)-5,7,2 '-trihydroxy-4 '-methoxy-3 '-(3 ''-methylbut-2 ''-enyl)-isoflavanone (platyisoflavanone B), 5,7-dihydroxy-4 '-methoxy-2 ''-(2 '''-hydroxyisopropyl)-dihydrofurano-[4 '',5 '':3 ',2 ']-isoflavanone (platyisoflavanone C) and 5,7,2 ',3 ''-tetrahydroxy-2 '',2 ''-dimethyldihydropyrano-[5 '',6 '':3 ',4 ']-isoflavanone (platyisoflavanone D). In addition, the known isoflavanones, sophoraisoflavanone A and glyasperin F; the isoflavone, formononetin; two flavones, kumatakenin and isokaempferide; as well as two triterpenes, betulin and beta-amyrin were identified. The structures were elucidated on the basis of spectroscopic evidence. Platyisoflavanone A showed antibacterial activity against Mycobacterium tuberculosis in the microplate alamar blue assay (MABA) with MIC = 23.7 mu M, but also showed cytotoxicity (IC50 = 21.1 mu M) in the vero cell test.
KW  - Platycelphium voense
KW  - Stem bark
KW  - Leguminosae
KW  - Isoflavanones
KW  - Platyisoflavanone
KW  - Mycobacterium tuberculosis
Y1  - 2012
U6  - https://doi.org/10.1016/j.phytol.2011.11.012
SN  - 1874-3900
VL  - 5
IS  - 1
SP  - 150
EP  - 154
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kerubo, Leonidah Omosa
A1  - Midiwo, Jacob Ogweno
A1  - Derese, Solomon
A1  - Langat, Moses K.
A1  - Akala, Hoseah M.
A1  - Waters, Norman C.
A1  - Peter, Martin
A1  - Heydenreich, Matthias
T1  - Antiplasmodial activity of compounds from the surface exudates of senecio roseiflorus
JF  - Natural product communications : an international journal for communications and reviews
N2  - From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.
KW  - Senecio roseiflorus
KW  - Asteraceae
KW  - Surface exudates
KW  - Antiplasmodial activity
Y1  - 2013
SN  - 1934-578X
VL  - 8
IS  - 2
SP  - 175
EP  - 176
PB  - NPC
CY  - Westerville
ER  - 
TY  - JOUR
A1  - Marco, Makungu
A1  - Deyou, Tsegaye
A1  - Gruhonjic, Amra
A1  - Holleran, John
A1  - Duffy, Sandra
A1  - Heydenreich, Matthias
A1  - Firtzpatrick, Paul A.
A1  - Landberg, Goran
A1  - Koch, Andreas
A1  - Derese, Solomon
A1  - Pelletier, Jerry
A1  - Avery, Vicky M.
A1  - Erdelyi, Mate
A1  - Yenesew, Abiy
T1  - Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura
JF  - Phytochemistry letters
KW  - Millettia micans
KW  - Millettia dura
KW  - Pterocarpan
KW  - Isoflavone
KW  - Cytotoxicity
KW  - Plasmodium falciparum
Y1  - 2017
U6  - https://doi.org/10.1016/j.phytol.2017.07.012
SN  - 1874-3900
SN  - 1876-7486
VL  - 21
SP  - 216
EP  - 220
PB  - Elsevier
CY  - Amsterdam
ER  -