TY - JOUR A1 - Ette, Ottmar T1 - Александр фон Гумбольдт T1 - Alexander von Humboldt BT - кочующая мысль и жизненная наука BT - nomadic thinking and living science JF - Epistemology & Philosophy of Science N2 - Научные интересы А. фон Гумбольдта протираются от ан­тропологии и доколумбовой истории Америки до геологии и географии, климатологии и теории культуры; от физики и географии растений до истории языка, вулканологии и зооло­гии. Будучи ученым, он пересекал дисциплинарные границы и искал новые пути познания. Гумбольдт развивал трансдис­циплинарное и, в широком смысле, номадическое знание. Как настоящий кочевник, он не стремился завоевать или разрушить территорию знания. И потому неудивительно, что он стал одним из основоположников экологического и гео-экологического мышления. Гумбольдт публиковал работы на немецком и французском языках. В своих «Американских дневниках», которые были возвращены в Берлин в ноябре 2013 г., но до сих пор не изучены, Гумбольдт постоянно пере­ходит с немецкого на французский, с латинского на испанский. Автор «Космоса» чужд всякого национализма. Гумбольдт – это номад от науки, и в этом смысле – гражданин мира. Первый теоретик глобализации кочевал от слова к слову, от науки к науке, от мира к миру. Для него постоянное перемещение бы­ло не просто основой научной программы, а образом жизни. Гумбольдт не стремился к специализации в знании, поскольку она ограничивает диалог с другими областями. Его мышление не укладывается в привычные понятия дисциплинарности или междисциплинарности. Оно взыскует нового мира, в котором человечество будет существовать в согласии и свободе. N2 - The long-term scientific interests of Alexander von Humboldt ranged from anthropology and ancient American studies to geology and geography, climatology and cultural theory, physics and plant geography to language history, volcanology and zoology. As a scientist, he crossed different disciplines and explored new paths of knowledge. Humboldt developed a transdisciplinary and, in the widest sense, nomadic knowledge as a traveller through the sciences. Like a nomad, he did not seek to possess or destroy a territory (of knowledge): no wonder that he became the co-founder of an ecological and geo-ecological thinking. Humboldt wrote and published his works in German as well as in French. In his American Travel Diaries, which returned to Berlin in November 2013, and which are still awaiting their scientific analysis, Humboldt constantly changes between German and French, but also between Latin and Spanish. The author of the Kosmos couldn’t be used for nationalist purposes. Thus, Alexander von Humboldt can be understood as a nomad of science in constant movement, and in this sense as a world citizen. This first theorist of globalization shifted between the words, between the sciences, between the worlds. For him, the greatest possible mobility was not only a scientific program, but also the program of a life – his life. Humboldt wasn’t concerned with any specialization that would lead to a fragmented dialogue with other specialists. He was concerned with a nomadic knowledge, which, thanks to his extensive network of correspondents, always delivered the opportunity to argue from different disciplinary standpoints at the same time. His thinking doesn’t know the limits of interdisciplinary or “disciplined” research oppressing us today, but it rather took aim at the creation of a new world, in which mankind would be able to live together on a planetary scale in freedom and peace. KW - Alexander von Humboldt KW - American Travel Diaries KW - Kosmos KW - nomadic Science KW - accelerated globalization KW - Humboldtian writing Y1 - 2018 U6 - https://doi.org/10.5840/eps201855113 SN - 1811-833X SN - 2311-7133 VL - 55 IS - 1 SP - 136 EP - 154 PB - Russian ACAD Sciences CY - Moscow ER - TY - JOUR A1 - Ulfstein, Geir A1 - Zimmermann, Andreas T1 - Certiorari through the Back Door? BT - the Judgment by the European Court of Human Rights in Burmych and Others v. Ukraine in Perspective JF - The Law & Practice of International Courts and Tribunals N2 - In its Burmych and Others v. Ukraine judgment of October 2017 the European Court of Human Rights dismissed more than 12,000 applications due to the fact that they were not only repetitive in nature, but also mutatis mutandis identical to applications covered by a previous pilot judgment rendered against Ukraine. This raises fundamental issues as to the role of the Court within the human rights protection system established by the European Convention on Human Rights, as well as those concerning the interrelationship between the Court and the Committee of Ministers. KW - European Court of Human Rights KW - Council of Europe KW - Committee of Ministers Y1 - 2018 U6 - https://doi.org/10.1163/15718034-12341381 SN - 1569-1853 SN - 1571-8034 VL - 17 IS - 2 SP - 289 EP - 308 PB - Brill CY - Leiden ER - TY - JOUR A1 - Vock, Miriam A1 - Gronostaj, Anna A1 - Kretschmann, Julia A1 - Westphal, Andrea T1 - „Meine Lehrer mögen mich“ – Soziale Integration von Kindern mit sonderpädagogischem Förderbedarf im gemeinsamen Unterricht in der Grundschule T1 - "My Teachers Like Me" - Social Integration of Children with Special Educational Needs in Inclusive Classes BT - Befunde aus dem Pilotprojekt „Inklusive Grundschule“ im Land Brandenburg BT - Findings from the Pilot Project "Inclusive Primary Schools" in the German State of Brandenburg JF - DDS – Die Deutsche Schule N2 - Brandenburg startete im Schuljahr 2012/2013 das Pilotprojekt „Inklusive Grundschule“ (PING). 35 dieser Pilot-Grundschulen wurden wissenschaftlich begleitet (vgl. Spörer, Schründer-Lenzen, Vock & Maaz, 2015). In diesem Beitrag berichten wir Befunde zum sozialen Selbstkonzept, wie die Kinder das Klassenklima erleben und wie sie sich von ihrer Lehrkraft angenommen fühlen. Untersucht wurden 1.435 Kinder in 61 inklusiven Klassen der Jahrgangsstufen 2 und 3. Es finden sich keine durchgängigen Nachteile bei Selbstkonzept und erlebtem Klassenklima für Kinder mit sonderpädagogischem Förderbedarf (SPF), jedoch fühlen sich diese weniger von ihren Lehrkräften angenommen. N2 - Brandenburg started the pilot project "Inclusive Primary Schools" (PING) in the school year 2012/2013. 35 of these pilot primary schools were scientifically supported (cp. Sporer, Schrunder-Lenzen, Vock & Maaz, 2015). In this article we report findings on the social self-concept, how children experience the class climate, and how they feel accepted by their teachers. The study examined 1,435 children in 61 inclusive 2nd and 3rd grade classes. There are no consistent disadvantages regarding self-concept and experienced class climate for children with special educational needs, but they feel less accepted by their teachers. KW - inclusion KW - primary school KW - social integration KW - special educational needs KW - inclusive education KW - Inklusion KW - Grundschule KW - soziale Integration KW - Förderbedarf KW - gemeinsamer Unterricht Y1 - 2018 U6 - https://doi.org/10.31244/dds.2018.02.03 SN - 0012-0731 VL - 110 IS - 2 SP - 124 EP - 137 PB - Waxmann CY - Münster ER - TY - JOUR A1 - de Abreu e Lima, Francisco Anastacio A1 - Leifels, Lydia A1 - Nikoloski, Zoran T1 - Regression-based modeling of complex plant traits based on metabolomics data JF - Plant Metabolomics N2 - Bridging metabolomics with plant phenotypic responses is challenging. Multivariate analyses account for the existing dependencies among metabolites, and regression models in particular capture such dependencies in search for association with a given trait. However, special care should be undertaken with metabolomics data. Here we propose a modeling workflow that considers all caveats imposed by such large data sets. KW - Metabolomics KW - Plants KW - Trait KW - Regression KW - Prediction KW - Modeling KW - R programing language KW - R software packages Y1 - 2018 SN - 978-1-4939-7819-9 SN - 978-1-4939-7818-2 U6 - https://doi.org/10.1007/978-1-4939-7819-9_23 SN - 1064-3745 SN - 1940-6029 VL - 1778 SP - 321 EP - 327 PB - Humana Press Inc. CY - New York ER - TY - JOUR A1 - Laux, Eva-Maria A1 - Bier, Frank Fabian A1 - Hölzel, Ralph T1 - Dielectrophoretic Stretching of DNA JF - DNA Nanotechnology N2 - The spatial control of DNA and of self-assembled DNA constructs is a prerequisite for the preparation of DNA-based nanostructures and microstructures and a useful tool for studies on single DNA molecules. Here we describe a protocol for the accumulation of dissolved lambda-DNA molecules between planar microelectrodes by the action of inhomogeneous radiofrequency electric fields. The resulting AC electrokinetic forces stretch the DNA molecules and align them parallel to the electric field. The electrode preparation from off-the-shelf electronic components is explained, and a detailed description of the electronic setup is given. The experimental procedure is controlled in real-time by fluorescence microscopy. KW - Alignment KW - Dielectrophoresis KW - DNA KW - Electrokinetics KW - Interdigitated electrodes KW - Stretching Y1 - 2018 SN - 978-1-4939-8582-1 SN - 978-1-4939-8581-4 U6 - https://doi.org/10.1007/978-1-4939-8582-1_14 SN - 1064-3745 SN - 1940-6029 SP - 199 EP - 208 PB - Humana Press Inc. CY - New York ET - 2 ER - TY - JOUR A1 - Hanke-Gogokhia, Christin A1 - Frederick, Jeanne M. A1 - Zhang, Houbin A1 - Baehr, Wolfgang T1 - Binary Function of ARL3-GTP Revealed by Gene Knockouts JF - Retinal Degenerative Diseases : Mechanisms and Experimental Therapy N2 - UNC119 and PDE delta are lipid-binding proteins and are thought to form diffusible complexes with transducin-alpha and prenylated OS proteins, respectively, to mediate their trafficking to photoreceptor outer segments. Here, we investigate mechanisms of trafficking which are controlled by Arf-like protein 3 (Arl3), a small GTPase. The activity of ARL3 is regulated by a GEF (ARL13b) and a GAP (RP2). In a mouse germline knockout of RP2, ARL3-GTP is abundant as its intrinsic GTPase activity is extremely low. High levels of ARL3-GTP impair binding and trafficking of cargo to the outer segment. Germline knockout of ARL3 is embryonically lethal generating a syndromic ciliopathy-like phenotype. Retina-and rod-specific knockout of ARL3 allow to determine the precise mechanisms leading to photoreceptor degeneration. The knockouts reveal binary functions of ARL3-GTP as a key molecule in late-stage photoreceptor ciliogenesis and cargo displacement factor. KW - ARL3 KW - ARL13b KW - PDE delta KW - UNC119 KW - RP2 KW - Photoreceptor KW - Germline knockout KW - Retina disease Y1 - 2018 SN - 978-3-319-75402-4 SN - 978-3-319-75401-7 U6 - https://doi.org/10.1007/978-3-319-75402-4_39 SN - 0065-2598 SN - 2214-8019 VL - 1074 SP - 317 EP - 325 PB - Springer CY - Cham ER - TY - JOUR A1 - Bösel, Bernd T1 - Affect Disposition(ing) BT - a genealogical approach to the organization and regulation of emotions JF - Media and Communication N2 - The “affective turn” has been primarily concerned not with what affect is, but what it does. This article focuses on yet another shift towards how affect gets organized, i.e., how it is produced, classified, and controlled. It proposes a genealogical as well as a critical approach to the organization of affect and distinguishes between several “affect disposition(ing) regimes”—meaning paradigms of how to interpret and manage affects, for e.g., encoding them as byproducts of demonic possession, judging them in reference to a moralistic framework, or subsuming them under an industrial regime. Bernard Stiegler’s concept of psychopower will be engaged at one point and expanded to include social media and affective technologies, especially Affective Computing. Finally, the industrialization and cybernetization of affect will be contrasted with poststructuralist interpretations of affects as events. KW - affect KW - Affective Computing KW - disposition KW - emotions KW - event KW - eventology KW - genealogy KW - psychopower KW - theory Y1 - 2018 U6 - https://doi.org/10.17645/mac.v6i3.1460 SN - 2183-2439 VL - 6 IS - 3 SP - 15 EP - 21 PB - Cogitatio Press CY - Lisbon ER - TY - JOUR A1 - Bruttel, Lisa Verena T1 - The Limits of Buyer Power BT - Experimental Evidence JF - Review of Behavioral Economics N2 - This paper studies the behavior of buyers confronting an incumbent monopolist and a potential market entrant in a repeated trade situation. In the experiment, buyers have two possibilities to demand lower prices in future trade periods. First, they can withhold demand. Second, they can voluntarily pay a higher price to the entrant in order to encourage future re-entry. Both these forms of buyer behavior occur in the experiment. They are less frequent when the number of buyers is large as opposed to small. A control treatment tests to what extent such behavior can be attributed to strategic motives. KW - Buyer Power KW - Market Entry KW - Experiment Y1 - 2018 U6 - https://doi.org/10.1561/105.00000082 SN - 2326-6198 SN - 2326-6201 VL - 5 IS - 2 SP - 149 EP - 167 PB - Now Publishers inc. CY - Hannover ER - TY - JOUR A1 - Arantzeta, Miren A1 - Webster, Janet A1 - Laka, Itziar A1 - Martinez-Zabaleta, Maite A1 - Howard, David T1 - What happens when they think they are right? BT - Error awareness analysis of sentence comprehension deficits in aphasia JF - Aphasiology : an international, interdisciplinary journal N2 - Background: Comprehension of non-canonical sentences is frequently characterised by chance level performance in people with aphasia (PWA). Chance level performance has been interpreted as guessing, but online data does not support this rendering. It is still not clear whether the incorrect sentence processing is guided by the compensatory strategies that PWA might employ to overcome linguistic difficulties.Aims: We aim to study to what extent people with non-fluent aphasia are aware of their sentence comprehension deficits.Methods & Procedures: This study combined offline and online data to investigate the effect of word order and error-awareness on sentence comprehension in a group of PWA and non-brain damaged (NBD) participants. The offline tasks involved auditory sentence picture-matching immediately followed by a confidence rating (CR). Participants were asked to judge the perceived correctness of their previous answer. Online data consisted of eye-tracking.Outcomes & Results: Replicating previous findings, PWA had significantly worse comprehension of Theme-Agent order compared to Agent-Theme order sentences. Controls showed ceiling level sentence comprehension. CR was a poor predictor of response accuracy in PWA, but moderate-good in NBD. A total of 6.8% of judgements were classified as guessing by PWA. Post hoc gaze data analysis indicated that CR was a predictor of the fixation pattern during the presentation of the linguistic stimuli.Conclusions: Results suggest that PWA were mostly unaware of their sentence comprehension errors and did not consciously employ strategies to compensate for their difficulties. KW - Aphasia KW - sentence comprehension KW - error awareness KW - eye-tracking KW - anosognosia Y1 - 2018 U6 - https://doi.org/10.1080/02687038.2017.1423270 SN - 0268-7038 SN - 1464-5041 VL - 32 IS - 12 SP - 1418 EP - 1444 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Blanchard, Gilles A1 - Hoffmann, Marc A1 - Reiss, Markus T1 - Optimal adaptation for early stopping in statistical inverse problems JF - SIAM/ASA Journal on Uncertainty Quantification N2 - For linear inverse problems Y = A mu + zeta, it is classical to recover the unknown signal mu by iterative regularization methods ((mu) over cap,(m) = 0,1, . . .) and halt at a data-dependent iteration tau using some stopping rule, typically based on a discrepancy principle, so that the weak (or prediction) squared-error parallel to A((mu) over cap (()(tau)) - mu)parallel to(2) is controlled. In the context of statistical estimation with stochastic noise zeta, we study oracle adaptation (that is, compared to the best possible stopping iteration) in strong squared- error E[parallel to((mu) over cap (()(tau)) - mu)parallel to(2)]. For a residual-based stopping rule oracle adaptation bounds are established for general spectral regularization methods. The proofs use bias and variance transfer techniques from weak prediction error to strong L-2-error, as well as convexity arguments and concentration bounds for the stochastic part. Adaptive early stopping for the Landweber method is studied in further detail and illustrated numerically. KW - linear inverse problems KW - early stopping KW - discrepancy principle KW - adaptive estimation KW - oracle inequality KW - Landweber iteration Y1 - 2018 U6 - https://doi.org/10.1137/17M1154096 SN - 2166-2525 VL - 6 IS - 3 SP - 1043 EP - 1075 PB - Society for Industrial and Applied Mathematics CY - Philadelphia ER -