TY  - JOUR
A1  - Büchner, Dörthe
A1  - John, Leonard
A1  - Mertens, Monique
A1  - Wessig, Pablo
T1  - Detection of dsDNA with [1,3]Dioxolo[4,5-f]benzodioxol (DBD) Dyes
JF  - Chemistry - a European journal
N2  - DBD fluorescent dyes have proven to be useful in numerous applications. To widen the range of biological applications, we propose three different types of DBD molecules that have been modified in such a way that DNA interaction becomes probable. After the successful synthesis of all three compounds, we tested their fluorescent properties and their DNA binding abilities. Two of the three probes exhibit an interaction with dsDNA with subsequent fluorescence enhancement. The determined binding constants of the two new DNA dyes are comparable to other minorgroove-binding dyes. Their large Stokes shifts and their long fluorescent lifetimes are outstanding features of these dyes.
KW  - DNA recognition
KW  - dyes/pigments
KW  - fluorescent probes
KW  - heterocycles
KW  - scatchard plot
Y1  - 2018
U6  - https://doi.org/10.1002/chem.201804057
SN  - 0947-6539
SN  - 1521-3765
VL  - 24
IS  - 60
SP  - 16183
EP  - 16190
PB  - Wiley-VCH
CY  - Weinheim
ER  -