TY - JOUR A1 - Rödel, Claudia Jasmin A1 - Abdelilah-Seyfried, Salim T1 - A zebrafish toolbox for biomechanical signaling in cardiovascular development and disease JF - Current opinion in hematology N2 - Purpose of review The zebrafish embryo has emerged as a powerful model organism to investigate the mechanisms by which biophysical forces regulate vascular and cardiac cell biology during development and disease. A versatile arsenal of methods and tools is available to manipulate and analyze biomechanical signaling. This review aims to provide an overview of the experimental strategies and tools that have been utilized to study biomechanical signaling in cardiovascular developmental processes and different vascular disease models in the zebrafish embryo. Within the scope of this review, we focus on work published during the last two years. Recent findings Genetic and pharmacological tools for the manipulation of cardiac function allow alterations of hemodynamic flow patterns in the zebrafish embryo and various types of transgenic lines are available to report endothelial cell responses to biophysical forces. These tools have not only revealed the impact of biophysical forces on cardiovascular development but also helped to establish more accurate models for cardiovascular diseases including cerebral cavernous malformations, hereditary hemorrhagic telangiectasias, arteriovenous malformations, and lymphangiopathies. Summary The zebrafish embryo is a valuable vertebrate model in which in-vivo manipulations of biophysical forces due to cardiac contractility and blood flow can be performed. These analyses give important insights into biomechanical signaling pathways that control endothelial and endocardial cell behaviors. The technical advances using this vertebrate model will advance our understanding of the impact of biophysical forces in cardiovascular pathologies. KW - angiogenesis KW - cardiovascular system KW - Danio rerio (zebrafish) KW - genetic KW - tools KW - mechanobiology Y1 - 2021 U6 - https://doi.org/10.1097/MOH.0000000000000648 SN - 1065-6251 SN - 1531-7048 VL - 28 IS - 3 SP - 198 EP - 207 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Hehn, Jennifer A1 - Mendez, Daniel A1 - Uebernickel, Falk A1 - Brenner, Walter A1 - Broy, Manfred T1 - On integrating design thinking for human-centered requirements engineering JF - IEEE software N2 - We elaborate on the possibilities and needs to integrate design thinking into requirements engineering, drawing from our research and project experiences. We suggest three approaches for tailoring and integrating design thinking and requirements engineering with complementary synergies and point at open challenges for research and practice. KW - requirements engineering KW - prototypes KW - software KW - electronic mail KW - tools KW - organizations KW - design thinking Y1 - 2019 U6 - https://doi.org/10.1109/MS.2019.2957715 SN - 0740-7459 SN - 1937-4194 VL - 37 IS - 2 SP - 25 EP - 31 PB - Inst. of Electr. and Electronics Engineers CY - Los Alamitos ER - TY - JOUR A1 - Przybylla, Mareen A1 - Romeike, Ralf T1 - Empowering learners with tools in CS education BT - physical computing in secondary schools JF - it - Information Technology N2 - In computer science, computer systems are both, objects of investigation and tools that enable creative learning and design. Tools for learning have a long tradition in computer science education. Already in the late 1960s, Papert developed a concept which had an immense impact on the development of informal education in the following years: his theory of constructionism understands learning as a creative process of knowledge construction that is most effective when learners create something purposeful that they can try out, show around, discuss, analyse and receive praise for. By now, there are numerous learning and programming environments that are based on the constructionist ideas. Modern tools offer opportunities for students to learn in motivating ways and gain impressive results in programming games, animations, implementing 3D models or developing interactive objects. This article gives an overview of computer science education research related to tools and media to be used in educational settings. We analyse different types of tools with a special focus on the categorization and development of tools for student adequate physical computing activities in the classroom. Research around the development and evaluation of tools and learning resources in the domain of physical computing is illustrated with the example of "My Interactive Garden", a constructionist learning and programming environment. It is explained how the results from empirical studies are integrated in the continuous development of the learning material. KW - tools KW - media KW - resources KW - computer science education KW - physical computing Y1 - 2018 U6 - https://doi.org/10.1515/itit-2017-0032 SN - 1611-2776 SN - 2196-7032 VL - 60 IS - 2 SP - 91 EP - 101 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Diethelm, Ira A1 - Syrbe, Jörn T1 - Let’s talk about CS! BT - Towards a suitable Classroom Language and Terminology of CS for Teaching JF - KEYCIT 2014 - Key Competencies in Informatics and ICT N2 - To communicate about a science is the most important key competence in education for any science. Without communication we cannot teach, so teachers should reflect about the language they use in class properly. But the language students and teachers use to communicate about their CS courses is very heterogeneous, inconsistent and deeply influenced by tool names. There is a big lack of research and discussion in CS education regarding the terminology and the role of concepts and tools in our science. We don’t have a consistent set of terminology that we agree on to be helpful for learning our science. This makes it nearly impossible to do research on CS competencies as long as we have not agreed on the names we use to describe these. This workshop intends to provide room to fill with discussion and first ideas for future research in this field. KW - Terminology KW - classroom language KW - CS concepts KW - competencies KW - tools Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-82983 SN - 1868-0844 SN - 2191-1940 IS - 7 SP - 411 EP - 414 PB - Universitätsverlag Potsdam CY - Potsdam ER -