TY - JOUR
A1 - Démaris, Alix
A1 - Widigson, Ella S. K.
A1 - Ilvemark, Johan F. K. F.
A1 - Steenholdt, Casper
A1 - Seidelin, Jakob B.
A1 - Huisinga, Wilhelm
A1 - Michelet, Robin
A1 - Aulin, Linda B. S.
A1 - Kloft, Charlotte
T1 - Ulcerative colitis and acute severe ulcerative colitis patients are overlooked in infliximab population pharmacokinetic models
BT - results from a comprehensive review
JF - Pharmaceutics / Molecular Diversity Preservation International
N2 - Ulcerative colitis (UC) is part of the inflammatory bowels diseases, and moderate to severe UC patients can be treated with anti-tumour necrosis alpha monoclonal antibodies, including infliximab (IFX). Even though treatment of UC patients by IFX has been in place for over a decade, many gaps in modelling of IFX PK in this population remain. This is even more true for acute severe UC (ASUC) patients for which early prediction of IFX pharmacokinetic (PK) could highly improve treatment outcome. Thus, this review aims to compile and analyse published population PK models of IFX in UC and ASUC patients, and to assess the current knowledge on disease activity impact on IFX PK. For this, a semi-systematic literature search was conducted, from which 26 publications including a population PK model analysis of UC patients receiving IFX therapy were selected. Amongst those, only four developed a model specifically for UC patients, and only three populations included severe UC patients. Investigations of disease activity impact on PK were reported in only 4 of the 14 models selected. In addition, the lack of reported model codes and assessment of predictive performance make the use of published models in a clinical setting challenging. Thus, more comprehensive investigation of PK in UC and ASUC is needed as well as more adequate reports on developed models and their evaluation in order to apply them in a clinical setting.
KW - infliximab
KW - inflammatory bowel disease
KW - ulcerative colitis
KW - acute severe
KW - disease activity
KW - pharmacokinetic
KW - pharmacometrics
Y1 - 2022
U6 - https://doi.org/10.3390/pharmaceutics14102095
SN - 1999-4923
VL - 14
IS - 10
PB - MDPI
CY - Basel
ER -
TY - JOUR
A1 - Grisic, Ana-Marija
A1 - Eser, Alexander
A1 - Huisinga, Wilhelm
A1 - Reinisch, Walter
A1 - Kloft, Charlotte
T1 - Quantitative relationship between infliximab exposure and inhibition of C-reactive protein synthesis to support inflammatory bowel disease management
JF - British journal of clinical pharmacology
N2 - Aim Quantitative and kinetic insights into the drug exposure-disease response relationship might enhance our knowledge on loss of response and support more effective monitoring of inflammatory activity by biomarkers in patients with inflammatory bowel disease (IBD) treated with infliximab (IFX). This study aimed to derive recommendations for dose adjustment and treatment optimisation based on mechanistic characterisation of the relationship between IFX serum concentration and C-reactive protein (CRP) concentration.
Methods Data from an investigator-initiated trial included 121 patients with IBD during IFX maintenance treatment. Serum concentrations of IFX, antidrug antibodies (ADA), CRP, and disease-related covariates were determined at the mid-term and end of a dosing interval. Data were analysed using a pharmacometric nonlinear mixed-effects modelling approach. An IFX exposure-CRP model was generated and applied to evaluate dosing regimens to achieve CRP remission.
Results The generated quantitative model showed that IFX has the potential to inhibit up to 72% (9% relative standard error [RSE]) of CRP synthesis in a patient. IFX concentration leading to 90% of the maximum CRP synthesis inhibition was 18.4 mu g/mL (43% RSE). Presence of ADA was the most influential factor on IFX exposure. With standard dosing strategy, >= 55% of ADA+ patients experienced CRP nonremission. Shortening the dosing interval and co-therapy with immunomodulators were found to be the most beneficial strategies to maintain CRP remission.
Conclusions With the generated model we could for the first time establish a robust relationship between IFX exposure and CRP synthesis inhibition, which could be utilised for treatment optimisation in IBD patients.
KW - C‐ reactive protein remission
KW - inflammatory bowel disease
KW - infliximab dosing
Y1 - 2020
U6 - https://doi.org/10.1111/bcp.14648
SN - 0306-5251
SN - 1365-2125
VL - 87
IS - 5
SP - 2374
EP - 2384
PB - Wiley
CY - Hoboken
ER -