TY  - JOUR
A1  - Boekstegers, Felix
A1  - Marcelain, Katherine
A1  - Barahona Ponce, Carol
A1  - Baez Benavides, Pablo F.
A1  - Müller, Bettina
A1  - de Toro, Gonzalo
A1  - Retamales, Javier
A1  - Barajas, Olga
A1  - Ahumada, Monica
A1  - Aleksandrova, Krasimira
A1  - Bermejo, Justo Lorenzo
T1  - ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans
JF  - Cancer Epidemiology
N2  - Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.
Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.
Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.
Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.
KW  - cancer epidemiology
KW  - gallbladder cancer
KW  - native American ancestry
KW  - population-specific risk marker
Y1  - 2020
VL  - 65
PB  - Elsevier
CY  - Amsterdam
ER  -