TY  - JOUR
A1  - Avila, Daiana Silva
A1  - Benedetto, Alexandre
A1  - Au, Catherine
A1  - Bornhorst, Julia
A1  - Aschner, Michael A.
T1  - Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans
JF  - Plant Methods
N2  - Background: All living cells display a rapid molecular response to adverse environmental conditions, and the heat shock protein family reflects one such example. Hence, failing to activate heat shock proteins can impair the cellular response. In the present study, we evaluated whether the loss of different isoforms of heat shock protein (hsp) genes in Caenorhabditis elegans would affect their vulnerability to Manganese (Mn) toxicity. Conclusions: Taken together, our data suggest that Mn exposure modulates heat shock protein expression, particularly HSP-70, in C. elegans. Furthermore, loss of hsp-70 increases protein oxidation and dopaminergic neuronal degeneration following manganese exposure, which is associated with the inhibition of pink1 increased expression, thus potentially exacerbating the vulnerability to this metal.
KW  - Caenorhabitis elegans
KW  - Manganese
KW  - Heat shock proteins
KW  - hsp-70
KW  - pink1
Y1  - 2016
U6  - https://doi.org/10.1186/s40360-016-0097-2
SN  - 2050-6511
VL  - 17
PB  - BioMed Central
CY  - London
ER  -