TY  - JOUR
A1  - Fruscalzo, Arrigo
A1  - Frommer, Julia-Marie
A1  - Londero, Ambrogio P.
A1  - Henze, Andrea
A1  - Schweigert, Florian J.
A1  - Nofer, Jerzy-Roch
A1  - Steinhard, Johannes
A1  - Klockenbusch, Walter
A1  - Schmitz, Ralf
A1  - Raila, Jens
T1  - First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant’s outcome
JF  - Archives of gynecology and obstetrics
N2  - To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA). Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight < 10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37). We found decreased RBP4 in SGA patients that delivered fetuses < 3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05). First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.
KW  - Low birth weight
KW  - Small for gestational age
KW  - Pregnancy
KW  - First trimester
KW  - Marker
KW  - RBP4
KW  - TTR
KW  - Retinol
KW  - Vitamin A
KW  - sFlt-1
KW  - PlGF
Y1  - 2017
U6  - https://doi.org/10.1007/s00404-017-4338-4
SN  - 0932-0067
SN  - 1432-0711
VL  - 295
SP  - 1157
EP  - 1165
PB  - Springer
CY  - Heidelberg
ER  -