TY - JOUR A1 - González Hauck, Sué A1 - Herrmann, Franziska A1 - Hettihewa, Julian A. A1 - Kraft, Dariush A1 - Milas, Max A1 - Springer, Stephanie A1 - Weckner, Franka T1 - Jurisdiction BT - Who speaks international law? JF - Zeitschrift für ausländisches öffentliches Recht und Völkerrecht Y1 - 2022 U6 - https://doi.org/10.17104/0044-2348-2022-2-289 SN - 0044-2348 VL - 82 IS - 2 SP - 289 EP - 298 PB - C.H. Beck CY - München ER - TY - JOUR A1 - Abujarour, Safa’a A1 - Köster, Antonia A1 - Krasnova, Hanna A1 - Wiesche, Manuel T1 - Technology as a source of power BT - Exploring how ICT use contributes to the social inclusion of refugees in Germany JF - Proceedings of the 54th Hawaii International Conference on System Sciences N2 - Since the beginning of the recent global refugee crisis, researchers have been tackling many of its associated aspects, investigating how we can help to alleviate this crisis, in particular, using ICTs capabilities. In our research, we investigated the use of ICT solutions by refugees to foster the social inclusion process in the host community. To tackle this topic, we conducted thirteen interviews with Syrian refugees in Germany. Our findings reveal different ICT usages by refugees and how these contribute to feeling empowered. Moreover, we show the sources of empowerment for refugees that are gained by ICT use. Finally, we identified the two types of social inclusion benefits that were derived from empowerment sources. Our results provide practical implications to different stakeholders and decision-makers on how ICT usage can empower refugees, which can foster the social inclusion of refugees, and what should be considered to support them in their integration effort. KW - culture, identity, and inclusion KW - empowerment KW - ict KW - refugees KW - social inclusion KW - technology Y1 - 2021 UR - https://hdl.handle.net/10125/70936 SN - 978-0-9981331-4-0 U6 - https://doi.org/10.24251/HICSS.2021.322 SN - 0073-1129 SP - 2637 EP - 2646 PB - Western Periodicals Co. CY - North Hollywood, Calif. ER - TY - JOUR A1 - Bilgen, Isa T1 - Freiheit und Nachhaltigkeit im Verfassungswandel JF - Verfassungsblog N2 - Mit dem Klima wandelt sich auch notwendig die offene Gesellschaft. Und mit ihr wandelt sich wiederum auch die Verfassung(-sinterpretation). Periodisch wiederkehrende Gesundheits- und Sicherheitskrisen fordern eine dynamische Reaktion des Grundgesetzes auf mit ihnen einhergehende Probleme. In andauernden Krisen wie der Umweltkrise muss die Verfassung gleichzeitig in vielerlei Hinsicht nachhaltig sein. Dabei muss das, was wir unter Freiheit, Klima‑, Umwelt- oder Tierschutz verstehen, immer im Wandel bleiben. Y1 - 2023 UR - https://verfassungsblog.de/freiheit-und-nachhaltigkeit-im-verfassungswandel/ U6 - https://doi.org/10.17176/20230617-231023-0 SN - 2366-7044 PB - Verfassungsblog.de CY - Berlin ER - TY - JOUR A1 - Xie, Chao A1 - Jia, Tianye A1 - Rolls, Edmund T. A1 - Robbins, Trevor W. A1 - Sahakian, Barbara J. A1 - Zhang, Jie A1 - Liu, Zhaowen A1 - Cheng, Wei A1 - Luo, Qiang A1 - Zac Lo, Chun-Yi A1 - Schumann, Gunter A1 - Feng, Jianfeng A1 - Wang, He A1 - Banaschewski, Tobias A1 - Barker, Gareth J. A1 - Bokde, Arun L.W. A1 - Büchel, Christian A1 - Quinlan, Erin Burke A1 - Desrivières, Sylvane A1 - Flor, Herta A1 - Grigis, Antoine A1 - Garavan, Hugh A1 - Gowland, Penny A1 - Heinz, Andreas A1 - Hohmann, Sarah A1 - Ittermann, Bernd A1 - Martinot, Jean-Luc A1 - Paillère Martinot, Marie-Laure A1 - Nees, Frauke A1 - Papadopoulos Orfanos, Dimitri A1 - Paus, Tomáš A1 - Poustka, Luise A1 - Fröhner, Juliane H. A1 - Smolka, Michael N. A1 - Walter, Henrik A1 - Whelan, Robert T1 - Reward versus nonreward sensitivity of the medial versus lateral orbitofrontal cortex relates to the severity of depressive symptoms JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging N2 - BACKGROUND: The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms. METHODS: Activations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14. RESULTS: The medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003). CONCLUSIONS: Activations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores. KW - adolescents KW - depression KW - monetary incentive delay task KW - nonreward sensitivity KW - orbitofrontal cortex KW - reward anticipation KW - reward sensitivity KW - ventral striatum Y1 - 2021 U6 - https://doi.org/10.1016/j.bpsc.2020.08.017 SN - 0006-3223 SN - 1873-2402 VL - 6 IS - 3 SP - 259 EP - 269 PB - Elsevier Science CY - Amsterdam ER - TY - JOUR A1 - Codeço, Marta S. A1 - Weis, Philipp A1 - Trumbull, Robert B. A1 - Van Hinsberg, Vincent A1 - Pinto, Filipe A1 - Lecumberri-Sanchez, Pilar A1 - Schleicher, Anja Maria T1 - The imprint of hydrothermal fluids on trace-element contents in white mica and tourmaline from the Panasqueira W–Sn–Cu deposit, Portugal JF - Mineralium Deposita N2 - White mica and tourmaline are the dominant hydrothermal alteration minerals at the world-class Panasqueira W-Sn-Cu deposit in Portugal. Thus, understanding the controls on their chemical composition helps to constrain ore formation processes at this deposit and determine their usefulness as pathfinder minerals for mineralization in general. We combine whole-rock geochemistry of altered and unaltered metasedimentary host rocks with in situ LA-ICP-MS measurements of tourmaline and white mica from the alteration halo. Principal component analysis (PCA) is used to better identify geochemical patterns and trends of hydrothermal alteration in the datasets. The hydrothermally altered metasediments are enriched in As, Sn, Cs, Li, W, F, Cu, Rb, Zn, Tl, and Pb relative to unaltered samples. In situ mineral analyses show that most of these elements preferentially partition into white mica over tourmaline (Li, Rb, Cs, Tl, W, and Sn), whereas Zn is enriched in tourmaline. White mica has distinct compositions in different settings within the deposit (greisen, vein selvages, wall rock alteration zone, late fault zone), indicating a compositional evolution with time. In contrast, tourmaline from different settings overlaps in composition, which is ascribed to a stronger dependence on host rock composition and also to the effects of chemical zoning and microinclusions affecting the LA-ICP-MS analyses. Hence, in this deposit, white mica is the better recorder of the fluid composition. The calculated trace-element contents of the Panasqueira mineralizing fluid based on the mica data and estimates of mica-fluid partition coefficients are in good agreement with previous fluid-inclusion analyses. A compilation of mica and tourmaline trace-element compositions from Panasqueira and other W-Sn deposits shows that white mica has good potential as a pathfinder mineral, with characteristically high Li, Cs, Rb, Sn, and W contents. The trace-element contents of hydrothermal tourmaline are more variable. Nevertheless, the compiled data suggest that high Sn and Li contents are distinctive for tourmaline from W-Sn deposits. KW - alteration geochemistry KW - tourmaline KW - white mica KW - Panasqueira KW - Tungsten–tin deposits KW - magmatic-hydrothermal systems KW - trace elements Y1 - 2020 U6 - https://doi.org/10.1007/s00126-020-00984-8 SN - 1432-1866 VL - 56 IS - 3 SP - 481 EP - 508 PB - Springer CY - Berlin; Heidelberg ER - TY - JOUR A1 - Thirumalaikumar, Venkatesh P. A1 - Gorka, Michal A1 - Schulz, Karina A1 - Masclaux-Daubresse, Celine A1 - Sampathkumar, Arun A1 - Skirycz, Aleksandra A1 - Vierstra, Richard D. A1 - Balazadeh, Salma T1 - Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1 JF - Autophagy N2 - In nature, plants are constantly exposed to many transient, but recurring, stresses. Thus, to complete their life cycles, plants require a dynamic balance between capacities to recover following cessation of stress and maintenance of stress memory. Recently, we uncovered a new functional role for macroautophagy/autophagy in regulating recovery from heat stress (HS) and resetting cellular memory of HS inArabidopsis thaliana. Here, we demonstrated that NBR1 (next to BRCA1 gene 1) plays a crucial role as a receptor for selective autophagy during recovery from HS. Immunoblot analysis and confocal microscopy revealed that levels of the NBR1 protein, NBR1-labeled puncta, and NBR1 activity are all higher during the HS recovery phase than before. Co-immunoprecipitation analysis of proteins interacting with NBR1 and comparative proteomic analysis of annbr1-null mutant and wild-type plants identified 58 proteins as potential novel targets of NBR1. Cellular, biochemical and functional genetic studies confirmed that NBR1 interacts with HSP90.1 (heat shock protein 90.1) and ROF1 (rotamase FKBP 1), a member of the FKBP family, and mediates their degradation by autophagy, which represses the response to HS by attenuating the expression ofHSPgenes regulated by the HSFA2 transcription factor. Accordingly, loss-of-function mutation ofNBR1resulted in a stronger HS memory phenotype. Together, our results provide new insights into the mechanistic principles by which autophagy regulates plant response to recurrent HS. KW - Arabidopsis thaliana KW - heat stress KW - HSFA2 KW - HSP90.1 KW - NBR1 KW - ROF1 KW - selective autophagy KW - stress memory KW - stress recovery Y1 - 2020 U6 - https://doi.org/10.1080/15548627.2020.1820778 SN - 1554-8635 VL - 17 IS - 9 SP - 2184 EP - 2199 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Machatschek, Rainhard Gabriel A1 - Saretia, Shivam A1 - Lendlein, Andreas T1 - Assessing the influence of temperature-memory creation on the degradation of copolyesterurethanes in ultrathin films JF - Advanced materials interfaces N2 - Copolyesterurethanes (PDLCLs) based on oligo(epsilon-caprolactone) (OCL) and oligo(omega-pentadecalactone) (OPDL) segments are biodegradable thermoplastic temperature-memory polymers. The temperature-memory capability in these polymers with crystallizable control units is implemented by a thermomechanical programming process causing alterations in the crystallite arrangement and chain organization. These morphological changes can potentially affect degradation. Initial observations on the macroscopic level inspire the hypothesis that switching of the controlling units causes an accelerated degradation of the material, resulting in programmable degradation by sequential coupling of functions. Hence, detailed degradation studies on Langmuir films of a PDLCL with 40 wt% OPDL content are carried out under enzymatic catalysis. The temperature-memory creation procedure is mimicked by compression at different temperatures. The evolution of the chain organization and mechanical properties during the degradation process is investigated by means of polarization-modulated infrared reflection absorption spectroscopy, interfacial rheology and to some extend by X-ray reflectivity. The experiments on PDLCL Langmuir films imply that degradability is not enhanced by thermal switching, as the former depends on the temperature during cold programming. Nevertheless, the thin film experiments show that the leaching of OCL segments does not induce further crystallization of the OPDL segments, which is beneficial for a controlled and predictable degradation. KW - block copolymers KW - degradation KW - Langmuir monolayers KW - rheology KW - temperature-memory polymers Y1 - 2021 U6 - https://doi.org/10.1002/admi.202001926 SN - 2196-7350 VL - 8 IS - 6 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - von Steinau-Steinrück, Robert T1 - Kurzarbeitergeld JF - Berliner Anwaltsblatt N2 - Das Kurzarbeitergeld (nachfolgend: KuG) ist eines der wichtigsten Instrumente zur Überwindung der aktuellen Corona-Krise. Der Staat übernimmt einen Teil der Lohnkosten und hilft so, gleichzeitig Arbeitsplätze zu erhalten und die Unternehmen zu entlasten. Kurzarbeit ist die vorübergehende Kürzung der betriebsüblichen normalen Arbeitszeit wegen Mangels an Arbeit bei entsprechender Minderung der Entgeltansprüche. Das KuG ersetzt den Teil des Entgelts, der in Folge des Arbeitsausfalls nicht erarbeitet und ausgezahlt werden kann. Ohne KuG läge das Wirtschaftsrisiko beim Arbeitgeber. Könnte er seine Mitarbeiter wegen der Corona-Krise nicht beschäftigen, würde er nach § 615 Satz 1 BGB den vollen Annahmeverzugslohn schulden. Davon entlastet ihn das Instrument der Kurzarbeit. Das KuG deckt die sog. „Nettoentgeltdifferenz“ zwischen dem bisherigen „Soll-Entgelt“ und dem nach Reduzierung von Arbeitszeit verbleibenden „Ist- Entgelt“ in Höhe von 60 % bzw. bei Arbeitnehmern mit Kindern 67 % ab. Schon in der Finanzkrise 2008/2009 hat sich das KuG hervorragend bewährt, damit Unternehmen ihre Belegschaft behalten können, um nach Ende der Krise wieder voll „durchzustarten“. Y1 - 2020 UR - https://berlineranwaltsblatt.de/ce/kurzarbeitergeld/detail.html SN - 0930-3065 SN - 2510-5116 IS - 06 SP - 223 EP - 224 PB - Erich Schmidt Verlag CY - Berlin ER - TY - JOUR A1 - Eckert, Sebastian A1 - Vaz da Cruz, Vinícius A1 - Ochmann, Miguel A1 - Ahnen, Inga von A1 - Föhlisch, Alexander A1 - Huse, Nils T1 - Breaking the symmetry of pyrimidine BT - solvent effects and core-excited state dynamics JF - The journal of physical chemistry letters N2 - Symmetry and its breaking crucially define the chemical properties of molecules and their functionality. Resonant inelastic X-ray scattering is a local electronic structure probe reporting on molecular symmetry and its dynamical breaking within the femtosecond scattering duration. Here, we study pyrimidine, a system from the C-2v point group, in an aqueous solution environment, using scattering though its 2a(2) resonance. Despite the absence of clean parity selection rules for decay transitions from in-plane orbitals, scattering channels including decay from the 7b(2) and 11a(1) orbitals with nitrogen lone pair character are a direct probe for molecular symmetry. Computed spectra of explicitly solvated molecules sampled from a molecular dynamics simulation are combined with the results of a quantum dynamical description of the X-ray scattering process. We observe dominant signatures of core-excited Jahn-Teller induced symmetry breaking for resonant excitation. Solvent contributions are separable by shortening of the effective scattering duration through excitation energy detuning. Y1 - 2021 U6 - https://doi.org/10.1021/acs.jpclett.1c01865 SN - 1948-7185 VL - 12 IS - 35 SP - 8637 EP - 8643 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Gleich, Tobias A1 - Spitta, Gianna A1 - Butler, Oisin A1 - Zacharias, Kristin A1 - Aydin, Semiha A1 - Sebold, Miriam Hannah A1 - Garbusow, Maria A1 - Rapp, Michael Armin A1 - Schubert, Florian A1 - Buchert, Ralph A1 - Heinz, Andreas A1 - Gallinat, Jürgen T1 - Dopamine D2/3 receptor availability in alcohol use disorder and individuals at high risk BT - towards a dimensional approach JF - Addiction Biology N2 - Alcohol use disorder (AUD) is the most common substance use disorder worldwide. Although dopamine-related findings were often observed in AUD, associated neurobiological mechanisms are still poorly understood. Therefore, in the present study, we investigate D2/3 receptor availability in healthy participants, participants at high risk (HR) to develop addiction (not diagnosed with AUD), and AUD patients in a detoxified stage, applying F-18-fallypride positron emission tomography (F-18-PET). Specifically, D2/3 receptor availability was investigated in (1) 19 low-risk (LR) controls, (2) 19 HR participants, and (3) 20 AUD patients after alcohol detoxification. Quality and severity of addiction were assessed with clinical questionnaires and (neuro)psychological tests. PET data were corrected for age of participants and smoking status. In the dorsal striatum, we observed significant reductions of D2/3 receptor availability in AUD patients compared with LR participants. Further, receptor availability in HR participants was observed to be intermediate between LR and AUD groups (linearly decreasing). Still, in direct comparison, no group difference was observed between LR and HR groups or between HR and AUD groups. Further, the score of the Alcohol Dependence Scale (ADS) was inversely correlated with D2/3 receptor availability in the combined sample. Thus, in line with a dimensional approach, striatal D2/3 receptor availability showed a linear decrease from LR participants to HR participants to AUD patients, which was paralleled by clinical measures. Our study shows that a core neurobiological feature in AUD seems to be detectable in an early, subclinical state, allowing more individualized alcohol prevention programs in the future. KW - alcohol KW - D2/3 receptors KW - dependence KW - dopamine KW - high risk KW - PET Y1 - 2020 U6 - https://doi.org/10.1111/adb.12915 SN - 1369-1600 SN - 1355-6215 VL - 26 IS - 2 SP - 1 EP - 10 PB - Wiley-Blackwell CY - Hoboken ER -