TY  - JOUR
A1  - Sand, Patrick
A1  - Schmidt, Bernd
T1  - Ruthenium-catalyzed sulfoalkenylation of acetanilides and dual-use of the catalyst directing group
JF  - European journal of organic chemistry
N2  - In contrast to vinylsulfonates and vinylsulfones, vinylsulfonamides are unreactive in Pd-catalyzed oxidative Heck-coupling reactions with acetanilides. This limitation has been resolved by using a C-H-activation protocol based on Ru-Cu-Ag-catalysis. Overall, the Ru-Cu-Ag-catalyzed conditions turned out to be more reliable and showed better reproducibility than the Pd-catalyzed C-H-activation. The coupling products thus obtained are functionalized styrenyl sulfones and -sulfonamides which can be used as starting materials for the synthesis of sulfonyl pyrroles and sulfonyl pyrrolo[2,3-c]quinolines.
KW  - Arenes
KW  - C-H activation
KW  - Heterocycles
KW  - Ruthenium
KW  - Sulfonamides
Y1  - 2021
U6  - https://doi.org/10.1002/ejoc.202101216
SN  - 1434-193X
SN  - 1099-0690
VL  - 2021
IS  - 40
SP  - 5497
EP  - 5506
PB  - Wiley-VCH
CY  - Weinheim
ER  -