TY - JOUR A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell A1 - Marschner, Alexander A1 - Mell, Thomas A1 - Villringer, Arno A1 - Reischies, Friedel M. T1 - Role of ventral striatum in reward-based decision making Y1 - 2007 SN - 0959-4965 ER - TY - JOUR A1 - Marschner, Alexander A1 - Mell, Thomas A1 - Wartenburger, Isabell A1 - Villringer, Arno A1 - Reischies, Friedel M. A1 - Heekeren, Hauke R. T1 - Reward-based decision-making and aging Y1 - 2005 SN - 0361-9230 ER - TY - JOUR A1 - van der Meer, Elke A1 - Beyer, Reinhard A1 - Horn, Judith A1 - Foth, Manja A1 - Bornemann, Boris A1 - Ries, Jan A1 - Kramer, Jürg A1 - Warmuth, Elke A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell T1 - Resource allocation and fluid intelligence ; insights from pupillometry Y1 - 2010 UR - http://www3.interscience.wiley.com/journal/118485671/home?CRETRY=1&SRETRY=0 SN - 0048-5772 ER - TY - JOUR A1 - Lausberg, Hedda A1 - Kazzer, Philipp A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell T1 - Pantomiming tool use with an imaginary tool in hand as compared to demonstration with tool in hand specifically modulates the left middle and superior temporal gyri JF - Cortex : a journal devoted to the study of the nervous system and behaviour N2 - Neuropsychological lesion studies evidence the necessity to differentiate between various forms of tool-related actions such as real tool use, tool use demonstration with tool in hand and without physical target object, and pantomime without tool in hand. However, thus far, neuroimaging studies have primarily focused only on investigating tool use pantomimes. The present fMRI study investigates pantomime without tool in hand as compared to tool use demonstration with tool in hand in order to explore patterns of cerebral signal modulation associated with acting with imaginary tools in hand. Fifteen participants performed with either hand (i) tool use pantomime with an imaginary tool in hand in response to visual tool presentation and (ii) tool use demonstration with tool in hand in response to visual-tactile tool presentation. In both conditions, no physical target object was present. The conjunction analysis of the right and left hands executions of tool use pantomime relative to tool use demonstration yielded significant activity in the left middle and superior temporal lobe. In contrast, demonstration relative to pantomime revealed large bihemispherically distributed homologous areas of activity. Thus far, fMRI studies have demonstrated the relevance of the left middle and superior temporal gyri in viewing, naming, and matching tools and related actions and contexts. Since in our study all these factors were equally (ir)relevant both in the tool use pantomime and the tool use demonstration conditions, the present findings enhance the knowledge about the function of these brain regions in tool-related cognitive processes. The two contrasted conditions only differ regarding the fact that the pantomime condition requires the individual to act with an imaginary tool in hand. Therefore, we suggest that the left middle and superior temporal gyri are specifically involved in integrating the projected mental image of a tool in the execution of a tool-specific movement concept. (C) 2015 Elsevier Ltd. All rights reserved. KW - Tool use pantomime KW - Tool use demonstration KW - Mental image KW - Left middle and superior temporal gyri KW - Hemispheric specialization Y1 - 2015 SN - 0010-9452 SN - 1973-8102 VL - 71 SP - 1 EP - 14 PB - Elsevier CY - Milano ER - TY - JOUR A1 - Scheibe, Christina A1 - Wartenburger, Isabell A1 - Wüstenberg, Torsten A1 - Kathmann, Norbert A1 - Villringer, Arno A1 - Heekeren, Hauke R. T1 - Neural correlates of the interaction between transient and sustained processes : a mixed blocked/event-related fMRI study Y1 - 2006 UR - http://www3.interscience.wiley.com/journal/38751/home SN - 1065-9471 ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Heekeren, Hauke R. A1 - Burchert, Frank A1 - Heinemann, Steffi A1 - De Bleser, Ria A1 - Villringer, Arno T1 - Neural correlates of syntactic transformations N2 - Many agrammatic aphasics have a specific syntactic comprehension deficit involving processing syntactic transformations. It has been proposed that this deficit is due to a dysfunction of Broca's area, an area that is thought to be critical for comprehension of complex transformed sentences. The goal of this study was to investigate the role of Broca's area in processing canonical and non-canonical sentences in healthy subjects. The sentences were presented auditorily and were controlled for task difficulty. Subjects were asked to judge the grammaticality of the sentences while their brain activity was monitored using event-related functional magnetic resonance imaging. Processing both kinds of sentences resulted in activation of language-related brain regions. Comparison of non-canonical and canonical sentences showed greater activation in bilateral temporal regions; a greater activation of Broca's area in processing antecedent-gap relations was not found. Moreover, the posterior part of Broca's area was conjointly activated by both sentence conditions. Broca's area is thus involved in general syntactic processing as required by grammaticality judgments and does not seem to have a specific role in processing syntactic transformations. (C) 2004 Wiley-Liss, Inc Y1 - 2004 UR - http://www3.interscience.wiley.com/journal/38751/home SN - 1065-9471 ER - TY - JOUR A1 - Mériau, Katja A1 - Wartenburger, Isabell A1 - Kazzer, Philipp A1 - Prehn, Kristin A1 - Villringer, Arno A1 - van der Meer, Elke A1 - Heekeren, Hauke R. T1 - Insular activity during passive viewing of aversive stimuli reflects individual differences in state negative affect N2 - People differ with regard to how they perceive, experience, and express negative affect. While trait negative affect reflects a stable, sustained personality trait, state negative affect represents a stimulus limited and temporally acute emotion. So far, little is known about the neural systems mediating the relationship between negative affect and acute emotion processing. To address this issue we investigated in a healthy female sample how individual differences in state negative affect are reflected in changes in blood oxygen level-dependent responses during passive viewing of emotional stimuli. To assess autonomic arousal we simultaneously recorded changes in skin conductance level. At the psychophysiological level we found increased skin conductance level in response to aversive relative to neutral pictures. However, there was no association of state negative affect with skin conductance level. At the neural level we found that high state negative affect was associated with increased left insular activity during passive viewing of aversive stimuli. The insula has been implicated in interoceptive processes and in the integration of sensory, visceral, and affective information thus contributing to subjective emotional experience. Greater recruitment of the insula in response to aversive relative to neutral stimuli in subjects with high state negative affect may represent increased processing of salient aversive stimuli. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/02782626 U6 - https://doi.org/10.1016/j.bandc.2008.05.006 SN - 0278-2626 ER - TY - JOUR A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell A1 - Schmidt, Helge A1 - Prehn, Kristin A1 - Schwintowski, Hans-Peter A1 - Villringer, Arno T1 - Influence of bodily harm on neural correlates of semantic and moral decision-making N2 - Moral decision-making is central to everyday social life because the evaluation of the actions of another agent or our own actions made with respect to the norms and values guides our behavior in a community. There is previous evidence that the presence of bodily harm-even if irrelevant for a decision-may affect the decision-making, process. While recent neuroimaging studies found a common neural substrate of moral decision-making, the role of bodily harm has not been systematically studied so far. Here we used event-related functional magnetic resonance imaging (fMRI) to investigate how behavioral and neural correlates of semantic and moral decision-making processes are modulated by the presence of direct bodily harm or violence in the stimuli. Twelve participants made moral and semantic decisions about sentences describing actions of agents that either contained bodily harm or not and that could easily be judged as being good or bad or correct/incorrect, respectively. During moral and semantic decision-making, the presence of bodily harm resulted in faster response times (RT) and weaker activity in the temporal poles relative to trials devoid of bodily harm/violence, indicating a processing advantage and reduced processing depth for violence-related linguistic stimuli. Notably, there was no increase in activity in the amygdala and the posterior cingulate cortex (PCC) in response to trials containing bodily harm. These findings might be a correlate of limited generation of the semantic and emotional context in the anterior temporal poles during the evaluation of actions of another agent related to violence that is made with respect to the norms and values guiding our behavior in a community. (C) 2004 Elsevier Inc. All rights reserved Y1 - 2005 SN - 1053-8119 ER - TY - JOUR A1 - Prehn, Kristin A1 - Wartenburger, Isabell A1 - Mériau, Katja A1 - Scheibe, Christina A1 - Goodenough, Oliver R. A1 - Villringer, Arno A1 - van der Meer, Elke A1 - Heekeren, Hauke R. T1 - Individual differences in moral judgment competence influence neural correlates of socio-normative judgments Y1 - 2008 UR - http://scan.oxfordjournals.org/content/by/year SN - 1749-5016 ER - TY - JOUR A1 - Passow, Susanne A1 - Westerhausen, Rene A1 - Wartenburger, Isabell A1 - Hugdahl, Kenneth A1 - Heekeren, Hauke R. A1 - Lindenberger, Ulman A1 - Li, Shu-Chen T1 - Human aging compromises attentional control of auditory perception JF - Psychology and aging N2 - Older adults often experience hearing difficulties in multitalker situations. Attentional control of auditory perception is crucial in situations where a plethora of auditory inputs compete for further processing. We combined an intensity-modulated dichotic listening paradigm with attentional manipulations to study adult age differences in the interplay between perceptual saliency and attentional control of auditory processing. When confronted with two competing sources of verbal auditory input, older adults modulated their attention less flexibly and were more driven by perceptual saliency than younger adults. These findings suggest that aging severely impairs the attentional regulation of auditory perception. KW - aging KW - auditory perception KW - attention KW - dichotic listening KW - hearing Y1 - 2012 U6 - https://doi.org/10.1037/a0025667 SN - 0882-7974 VL - 27 IS - 1 SP - 99 EP - 105 PB - American Psychological Association CY - Washington ER -