TY  - JOUR
A1  - Reiche, Jürgen
A1  - Kratz, Karl
A1  - Hofmann, Dieter
A1  - Lendlein, Andreas
T1  - Current status of Langmuir monolayer degradation of polymeric biomaterials
JF  - The international journal of artificial organs
N2  - Langmuir monolayer degradation (LMD) experiments with polymers possessing outstanding biomedical application potential yield information regarding the kinetics of their hydrolytic or enzymatic chain scission under well-defined and adjustable degradation conditions. A brief review is given of LMD investigations, including the author's own work on 2-dimensional (2D) polymer systems, providing chain scission data, which are not disturbed by simultaneously occurring transport phenomena, such as water penetration into the sample or transport of scission fragments out of the sample.
 A knowledge-based approach for the description and simulation of polymer hydrolytic and enzymatic degradation based on a combination of fast LMD experiments and computer simulation of the water penetration is briefly introduced. Finally, the advantages and disadvantages of this approach are discussed.
KW  - Monolayer
KW  - Hydrolytic degradation
KW  - Enzymatic degradation
KW  - Biomaterial
KW  - Degradable polymer
Y1  - 2011
U6  - https://doi.org/10.5301/IJAO.2011.6401
SN  - 0391-3988
VL  - 34
IS  - 2
SP  - 123
EP  - 128
PB  - Wichtig
CY  - Milano
ER  - 
TY  - JOUR
A1  - Köpf, Michael H.
A1  - Harder, Heiko
A1  - Reiche, Jürgen
A1  - Santer, Svetlana
T1  - Impact of temperature on the LB patterning of DPPC on Mica
JF  - Langmuir
N2  - The influence of the subphase temperature on the stripe pattern formation during Langmuir-Blodgett transfer (LB patterning) is investigated in a combined experimental and theoretical study. According to our experiments on the LB transfer of dipalmitoylphosphatidylcholine (DPPC) on planar mica substrates, even small temperature changes between 21.5 and 24.5 degrees C lead to significant changes in the monolayer patterns. For a constant surface pressure and dipper speed, the width of the stripes and the overall spatial period of the patterns increase with increasing subphase temperature. Because the stripe patterns are ascribed to alternating monolayer domains in the liquid-expanded and the liquid-condensed phases, the working regime for the formation of stripes is found to depend strongly on the respective surface pressure-area isotherm. These experimental findings are in accordance with the results of a theoretical investigation based on a model that takes hydrodynamics and the monolayer thermodynamics into account.
Y1  - 2011
U6  - https://doi.org/10.1021/la202728t
SN  - 0743-7463
VL  - 27
IS  - 20
SP  - 12354
EP  - 12360
PB  - American Chemical Society
CY  - Washington
ER  -