TY  - JOUR
A1  - Rottke, Falko O.
A1  - Heyne, Marie-Victoria
A1  - Reinicke, Stefan
T1  - Switching enzyme activity by a temperature responsive inhibitor modified polymer
JF  - Chemical communications
N2  - A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. This polymer-inhibitor conjugate inhibits AChE at room temperature and enables reactivation of AChE by heating above the cloud point of the conjugate.
Y1  - 2020
U6  - https://doi.org/10.1039/c9cc09385k
SN  - 1359-7345
SN  - 1364-548X
VL  - 56
IS  - 16
SP  - 2459
EP  - 2462
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -