TY  - JOUR
A1  - Xu, Xun
A1  - Nie, Yan
A1  - Wang, Weiwei
A1  - Ma, Nan
A1  - Lendlein, Andreas
T1  - Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cells
JF  - MRS communications / a publication of the Materials Research Society
N2  - Toll-like receptor (TLR) can trigger an immune response against virus including SARS-CoV-2. TLR expression/distribution is varying in mesenchymal stromal cells (MSCs) depending on their culture environments. Here, to explore the effect of periodic thermomechanical cues on TLRs, thermally controlled shape-memory polymer sheets with programmable actuation capacity were created. The proportion of MSCs expressing SARS-CoV-2-associated TLRs was increased upon stimulation. The TLR4/7 colocalization was promoted and retained in the endoplasmic reticula. The TLR redistribution was driven by myosin-mediated F-actin assembly. These results highlight the potential of boosting the immunity for combating COVID-19 via thermomechanical preconditioning of MSCs.
KW  - Actuation
KW  - Antiviral
KW  - Biomaterial
KW  - COVID-19
KW  - Shape memory
Y1  - 2021
U6  - https://doi.org/10.1557/s43579-021-00049-5
SN  - 2159-6859
SN  - 2159-6867
VL  - 11
IS  - 4
SP  - 425
EP  - 431
PB  - Springer
CY  - Berlin
ER  -