TY  - JOUR
A1  - Schmälzlin, Elmar Gerd
A1  - Moralejo, Benito
A1  - Gersonde, Ingo
A1  - Schleusener, Johannes
A1  - Darvin, Maxim E.
A1  - Thiede, Gisela
A1  - Roth, Martin M.
T1  - Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination
JF  - Journal of biomedical optics
N2  - Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
KW  - Raman spectroscopy
KW  - cancer diagnosis
KW  - Raman imaging
KW  - multichannel
KW  - astronomy
KW  - epidermis
KW  - dermis
Y1  - 2018
U6  - https://doi.org/10.1117/1.JBO.23.10.105001
SN  - 1083-3668
SN  - 1560-2281
VL  - 23
IS  - 10
PB  - SPIE
CY  - Bellingham
ER  -