TY  - JOUR
A1  - Kallies, Gunnar
A1  - Rapp, Michael Armin
A1  - Fydrich, Thomas
A1  - Fehm, Lydia
A1  - Tschorn, Mira
A1  - Teran, Christina
A1  - Schwefel, Melanie
A1  - Pietrek, Anou F.
A1  - Henze, Romy
A1  - Hellweg, Rainer
A1  - Ströhle, Andreas
A1  - Heinzel, Stephan
A1  - Heissel, Andreas
T1  - Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder
JF  - Psychoneuroendocrinology
N2  - Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p<.001) when adjusting for plasma volume shift and controlling for number of platelets. The interaction of sBDNF change and number of platelets was also significant (p=.001) indicating larger sBDNF-increase in participants with smaller number of platelets. Thus, findings of this study suggest an involvement of peripheral as well as additional possibly brain-derived mechanisms explaining exercise-related BDNF release in MDD. For future studies in the field of exercise-related BDNF research, the importance of controlling for peripheral parameters is emphasized.
KW  - Brain-derived neurotrophic factor (BDNF)
KW  - Platelets
KW  - Major depressive disorder
KW  - Physical exercise
Y1  - 2018
U6  - https://doi.org/10.1016/j.psyneuen.2018.12.015
SN  - 0306-4530
VL  - 102
SP  - 212
EP  - 215
PB  - Elsevier
CY  - Oxford
ER  -