TY  - JOUR
A1  - Friedrich, Thomas
A1  - Oberkofler, Vicky
A1  - Trindade, Inês
A1  - Altmann, Simone
A1  - Brzezinka, Krzysztof
A1  - Lämke, Jörn S.
A1  - Gorka, Michal
A1  - Kappel, Christian
A1  - Sokolowska, Ewelina
A1  - Skirycz, Aleksandra
A1  - Graf, Alexander
A1  - Bäurle, Isabel
T1  - Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis
JF  - Nature Communications
N2  - Adaptive plasticity in stress responses is a key element of plant survival strategies. For instance, moderate heat stress (HS) primes a plant to acquire thermotolerance, which allows subsequent survival of more severe HS conditions. Acquired thermotolerance is actively maintained over several days (HS memory) and involves the sustained induction of memory-related genes. Here we show that FORGETTER3/ HEAT SHOCK TRANSCRIPTION FACTOR A3 (FGT3/HSFA3) is specifically required for physiological HS memory and maintaining high memory-gene expression during the days following a HS exposure. HSFA3 mediates HS memory by direct transcriptional activation of memory-related genes after return to normal growth temperatures. HSFA3 binds HSFA2, and in vivo both proteins form heteromeric complexes with additional HSFs. Our results indicate that only complexes containing both HSFA2 and HSFA3 efficiently promote transcriptional memory by positively influencing histone H3 lysine 4 (H3K4) hyper-methylation. In summary, our work defines the major HSF complex controlling transcriptional memory and elucidates the in vivo dynamics of HSF complexes during somatic stress memory. Moderate heat stress primes plants to acquire tolerance to subsequent, more severe heat stress. Here the authors show that the HSFA3 transcription factor forms a heteromeric complex with HSFA2 to sustain activated transcription of genes required for acquired thermotolerance by promoting H3K4 hyper-methylation.
Y1  - 2021
U6  - https://doi.org/10.1038/s41467-021-23786-6
SN  - 2041-1723
VL  - 12
IS  - 1
PB  - Nature Publishing Group UK
CY  - [London]
ER  -