TY  - JOUR
A1  - Hortobagyi, Tibor
A1  - Granacher, Urs
A1  - Fernandez-del-Olmo, Miguel
A1  - Howatson, Glyn
A1  - Manca, Andrea
A1  - Deriu, Franca
A1  - Taube, Wolfgang
A1  - Gruber, Markus
A1  - Marquez, Gonzalo
A1  - Lundbye-Jensen, Jesper
A1  - Colomer-Poveda, David
T1  - Functional relevance of resistance training-induced neuroplasticity in health and disease
JF  - Neuroscience & biobehavioral reviews : official journal of the International Behavioral Neuroscience Society
N2  - Repetitive, monotonic, and effortful voluntary muscle contractions performed for just a few weeks, i.e., resistance training, can substantially increase maximal voluntary force in the practiced task and can also increase gross motor performance. The increase in motor performance is often accompanied by neuroplastic adaptations in the central nervous system. While historical data assigned functional relevance to such adaptations induced by resistance training, this claim has not yet been systematically and critically examined in the context of motor performance across the lifespan in health and disease. A review of muscle activation, brain and peripheral nerve stimulation, and imaging data revealed that increases in motor performance and neuroplasticity tend to be uncoupled, making a mechanistic link between neuroplasticity and motor performance inconclusive. We recommend new approaches, including causal mediation analytical and hypothesis-driven models to substantiate the functional relevance of resistance training-induced neuroplasticity in the improvements of gross motor function across the lifespan in health and disease.
KW  - Maximal voluntary contraction (MVC)
KW  - strength training
KW  - Electromyography (EMG)
KW  - Transcranial magnetic brain stimulation (TMS)
KW  - Electroencephalography (EEG)
KW  - Functional magnetic resonance imaging (fMRI)
KW  - athletic performance
KW  - aging
KW  - Parkinson's disease
KW  - Multiple sclerosis
KW  - stroke
KW  - directed acyclic graphs
KW  - causal mediation analysis
Y1  - 2020
U6  - https://doi.org/10.1016/j.neubiorev.2020.12.019
SN  - 0149-7634
SN  - 1873-7528
VL  - 122
SP  - 79
EP  - 91
PB  - Elsevier
CY  - Oxford
ER  -