44549
2020
2019
eng
12
XX
article
Nature Publ. Group
London
1
2020-01-31
2019-09-26
--
Bayesian Data Assimilation to Support Informed Decision Making in Individualized Chemotherapy
An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes. Current Bayesian forecasting tools typically rely only on the most probable model parameters (maximum a posteriori (MAP) estimate). This MAP-based approach, however, does neither necessarily predict the most probable outcome nor does it quantify the risks of treatment inefficacy or toxicity. Bayesian data assimilation (DA) methods overcome these limitations by providing a comprehensive uncertainty quantification. We compare DA methods with MAP-based approaches and show how probabilistic statements about key markers related to chemotherapy-induced neutropenia can be leveraged for more informative decision support in individualized chemotherapy. Sequential Bayesian DA proved to be most computationally efficient for handling interoccasion variability and integrating TDM data. For new digital monitoring devices enabling more frequent data collection, these features will be of critical importance to improve patient care decisions in various therapeutic areas.
CPT: Pharmacometrics & Systems Pharmacology
10.1002/psp4.12492
2163-8306
Universität Potsdam
PA 2020_025
1586.27
<a href="https://doi.org/10.25932/publishup-44550">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 827</a>
false
true
CC-BY - Namensnennung 4.0 International
Corinna Maier
Niklas Hartung
Jana de Wiljes
Charlotte Kloft
Wilhelm Huisinga
eng
uncontrolled
Induced neutropenia
eng
uncontrolled
Model
eng
uncontrolled
Myelosuppression
eng
uncontrolled
Prediction
Medizin und Gesundheit
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Publikationsfonds der Universität Potsdam
Open Access
41249
2016
2019
eng
16
611
postprint
1
2019-02-15
2019-02-15
--
The Hominin Sites and Paleolakes Drilling Project
The role that climate and environmental history may have played in influencing human evolution has been the focus of considerable interest and controversy among paleoanthropologists for decades. Prior attempts to understand the environmental history side of this equation have centered around the study of outcrop sediments and fossils adjacent to where fossil hominins (ancestors or close relatives of modern humans) are found, or from the study of deep sea drill cores. However, outcrop sediments are often highly weathered and thus are unsuitable for some types of paleoclimatic records, and deep sea core records come from long distances away from the actual fossil and stone tool remains. The Hominin Sites and Paleolakes Drilling Project (HSPDP) was developed to address these issues. The project has focused its efforts on the eastern African Rift Valley, where much of the evidence for early hominins has been recovered. We have collected about 2 km of sediment drill core from six basins in Kenya and Ethiopia, in lake deposits immediately adjacent to important fossil hominin and archaeological sites. Collectively these cores cover in time many of the key transitions and critical intervals in human evolutionary history over the last 4 Ma, such as the earliest stone tools, the origin of our own genus Homo, and the earliest anatomically modern Homo sapiens. Here we document the initial field, physical property, and core description results of the 2012-2014 HSPDP coring campaign.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
inferring the environmental context of human evolution from eastern African rift lake deposits
10.25932/publishup-41249
urn:nbn:de:kobv:517-opus4-412498
online registration
false
true
CC-BY - Namensnennung 4.0 International
Abby Cohen
Christopher Campisano
J. Ramon Arrowsmith
Asfawossen Asrat
A. K. Behrensmeyer
A. Deino
C. Feibel
A. Hill
R. Johnson
J. Kingston
Henry F. Lamb
T. Lowenstein
A. Noren
D. Olago
Richard Bernhart Owen
R. Potts
Kate Reed
R. Renaut
F. Schäbitz
J.-J. Tiercelin
Martin H. Trauth
J. Wynn
S. Ivory
K. Brady
R. O’Grady
J. Rodysill
J. Githiri
Joellen Russell
Verena Foerster
René Dommain
J. S. Rucina
D. Deocampo
J. Russell
A. Billingsley
C. Beck
G. Dorenbeck
L. Dullo
D. Feary
D. Garello
R. Gromig
T. Johnson
Annett Junginger
M. Karanja
E. Kimburi
A. Mbuthia
Tannis McCartney
E. McNulty
V. Muiruri
E. Nambiro
E. W. Negash
D. Njagi
J. N. Wilson
N. Rabideaux
Timothy Raub
Mark Jan Sier
P. Smith
J. Urban
M. Warren
M. Yadeta
Chad Yost
B. Zinaye
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
611
eng
uncontrolled
Turkana-Basin
eng
uncontrolled
Adar formation
eng
uncontrolled
climate-change
eng
uncontrolled
olorgesailie formation
eng
uncontrolled
Southern Ethiopia
eng
uncontrolled
global climate
eng
uncontrolled
Kenya Rift
eng
uncontrolled
Pleistocene
eng
uncontrolled
variability
eng
uncontrolled
patterns
Geowissenschaften
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Copernicus
Universität Potsdam
https://publishup.uni-potsdam.de/files/41249/pmnr611.pdf
45967
2018
2020
eng
20
938
postprint
1
2020-06-04
2020-06-04
--
Damage and protection cost curves for coastal floods within the 600 largest European cities
The economic assessment of the impacts of storm surges and sea-level rise in coastal cities requires high-level information on the damage and protection costs associated with varying flood heights. We provide a systematically and consistently calculated dataset of macroscale damage and protection cost curves for the 600 largest European coastal cities opening the perspective for a wide range of applications. Offering the first comprehensive dataset to include the costs of dike protection, we provide the underpinning information to run comparative assessments of costs and benefits of coastal adaptation. Aggregate cost curves for coastal flooding at the city-level are commonly regarded as by-products of impact assessments and are generally not published as a standalone dataset. Hence, our work also aims at initiating a more critical discussion on the availability and derivation of cost curves.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-45967
urn:nbn:de:kobv:517-opus4-459672
1866-8372
Scientific Data 5 (2018) 180034 DOI: 10.1038/sdata.2018.34
180034
<a href="http://publishup.uni-potsdam.de/53314">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Boris F. Prahl
Markus Boettle
Luís Fílípe Carvalho da Costa
Jürgen Peter Kropp
Diego Rybski
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
938
eng
uncontrolled
sea-level rise
eng
uncontrolled
topographic data
eng
uncontrolled
climate-change
eng
uncontrolled
adaptation
eng
uncontrolled
scale
eng
uncontrolled
exposure
eng
uncontrolled
model
Naturwissenschaften und Mathematik
Biowissenschaften; Biologie
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/45967/pmnr938.pdf
44581
2020
2020
eng
17
840
postprint
1
2020-03-10
2020-03-10
--
The Feasibility and Effectiveness of a New Practical Multidisciplinary Treatment for Low-Back Pain
Low-back pain is a major health problem exacerbated by the fact that most treatments are not suitable for self-management in everyday life. Particularly, interdisciplinary programs consist of intensive therapy lasting several weeks. Additionally, therapy components are rarely coordinated regarding reinforcing effects, which would improve complaints in persons with higher pain. This study assesses the effectiveness of a self-management program, firstly for persons suffering from higher pain and secondly compared to regular routines. Study objectives were treated in a single-blind multicenter controlled trial. A total of n = 439 volunteers (age 18–65 years) were randomly assigned to a twelve-week multidisciplinary sensorimotor training (3-weeks-center- and 9-weeks-homebased) or control group. The primary outcome pain (Chronic-Pain-Grade) as well as mental health were assessed by questionnaires at baseline and follow-up (3/6/12/24 weeks, M2-M5). For statistical analysis, multiple linear regression models were used. N = 291 (age 39.7 ± 12.7 years, female = 61.1%, 77% CPG = 1) completed training (M1/M4/M5), showing a significantly stronger reduction of mental health complaints (anxiety, vital exhaustion) in people with higher than those with lower pain in multidisciplinary treatment. Compared to regular routines, the self-management–multidisciplinary treatment led to a clinically relevant reduction of pain–disability and significant mental health improvements. Low-cost exercise programs may provide enormous relief for therapeutic processes, rehabilitation aftercare, and thus, cost savings for the health system
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
A Randomized Controlled Trial
10.25932/publishup-44581
urn:nbn:de:kobv:517-opus4-445814
1866-8372
Journal of Clinical Medicine 9 (2020) 115 DOI: 10.3390/jcm9010115
<a href="http://publishup.uni-potsdam.de/44582">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Pia-Maria Wippert
David Drießlein
Heidrun Beck
Christian Schneider
Anne-Katrin Puschmann
Winfried Banzer
Marcus Schiltenwolf
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
840
eng
uncontrolled
low-back pain
eng
uncontrolled
multidisciplinary pain treatment
eng
uncontrolled
sensorimotor exercise training
eng
uncontrolled
classical conditioning
eng
uncontrolled
executive function
eng
uncontrolled
MiSpEx Network
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/44581/pmnr840.pdf
40759
2016
2018
eng
16
postprint
1
2018-06-19
2018-06-19
--
Is hybridization a source of adaptive venom variation in rattlesnakes?
Venomous snakes often display extensive variation in venom composition both between and within species. However, the mechanisms underlying the distribution of different toxins and venom types among populations and taxa remain insufficiently known. Rattlesnakes (Crotalus, Sistrurus) display extreme inter-and intraspecific variation in venom composition, centered particularly on the presence or absence of presynaptically neurotoxic phospholipases A2 such as Mojave toxin (MTX). Interspecific hybridization has been invoked as a mechanism to explain the distribution of these toxins across rattlesnakes, with the implicit assumption that they are adaptively advantageous. Here, we test the potential of adaptive hybridization as a mechanism for venom evolution by assessing the distribution of genes encoding the acidic and basic subunits of Mojave toxin across a hybrid zone between MTX-positive Crotalus scutulatus and MTX-negative C. viridis in southwestern New Mexico, USA. Analyses of morphology, mitochondrial and single copy-nuclear genes document extensive admixture within a narrow hybrid zone. The genes encoding the two MTX subunits are strictly linked, and found in most hybrids and backcrossed individuals, but not in C. viridis away from the hybrid zone. Presence of the genes is invariably associated with presence of the corresponding toxin in the venom. We conclude that introgression of highly lethal neurotoxins through hybridization is not necessarily favored by natural selection in rattlesnakes, and that even extensive hybridization may not lead to introgression of these genes into another species.
Toxins
a test, using a crotalus scutulatus × viridis hybrid zone in southwestern New Mexico
urn:nbn:de:kobv:517-opus4-407595
online registration
MDPI Toxins 8 (2016); DOI: 10.3390/toxins8060188
CC-BY - Namensnennung 4.0 International
Giulia Zancolli
Timothy G. Baker
Axel Barlow
Rebecca K. Bradley
Juan J. Calvete
Kimberley C. Carter
Kaylah de Jager
John Benjamin Owens
Jenny Forrester Price
Libia Sanz
Amy Scholes-Higham
Liam Shier
Liam Wood
Catharine E. Wüster
Wolfgang Wüster
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
443
eng
uncontrolled
adaptation
eng
uncontrolled
Crotalus
eng
uncontrolled
evolution
eng
uncontrolled
hybridization
eng
uncontrolled
introgression
eng
uncontrolled
Mojave toxin
eng
uncontrolled
molecular evolution
eng
uncontrolled
venom
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Institut für Biochemie und Biologie
Referiert
Open Access
Multidisciplinary Digital Publishing Institute (MDPI)
Universität Potsdam
https://publishup.uni-potsdam.de/files/40759/pmnr_443.online.pdf
42255
2019
2019
eng
12
505
postprint
1
2019-01-10
2019-01-10
--
Historical biogeography of the leopard (Panthera pardus) and its extinct Eurasian populations
Background
Resolving the historical biogeography of the leopard (Panthera pardus) is a complex issue, because patterns inferred from fossils and from molecular data lack congruence. Fossil evidence supports an African origin, and suggests that leopards were already present in Eurasia during the Early Pleistocene. Analysis of DNA sequences however, suggests a more recent, Middle Pleistocene shared ancestry of Asian and African leopards. These contrasting patterns led researchers to propose a two-stage hypothesis of leopard dispersal out of Africa: an initial Early Pleistocene colonisation of Asia and a subsequent replacement by a second colonisation wave during the Middle Pleistocene. The status of Late Pleistocene European leopards within this scenario is unclear: were these populations remnants of the first dispersal, or do the last surviving European leopards share more recent ancestry with their African counterparts?
Results
In this study, we generate and analyse mitogenome sequences from historical samples that span the entire modern leopard distribution, as well as from Late Pleistocene remains. We find a deep bifurcation between African and Eurasian mitochondrial lineages (~ 710 Ka), with the European ancient samples as sister to all Asian lineages (~ 483 Ka). The modern and historical mainland Asian lineages share a relatively recent common ancestor (~ 122 Ka), and we find one Javan sample nested within these.
Conclusions
The phylogenetic placement of the ancient European leopard as sister group to Asian leopards suggests that these populations originate from the same out-of-Africa dispersal which founded the Asian lineages. The coalescence time found for the mitochondrial lineages aligns well with the earliest undisputed fossils in Eurasia, and thus encourages a re-evaluation of the identification of the much older putative leopard fossils from the region. The relatively recent ancestry of all mainland Asian leopard lineages suggests that these populations underwent a severe population bottleneck during the Pleistocene. Finally, although only based on a single sample, the unexpected phylogenetic placement of the Javan leopard could be interpreted as evidence for exchange of mitochondrial lineages between Java and mainland Asia, calling for further investigation into the evolutionary history of this subspecies.
Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
1866-8372
10.25932/publishup-42255
urn:nbn:de:kobv:517-opus4-422555
BMC Evolutionary Biology 18 (2018) 156 DOI: 10.1186/s12862-018-1268-0
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/42256">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Johanna L. A. Paijmans
Axel Barlow
Daniel W. Förster
Kirstin Henneberger
Matthias Meyer
Birgit Nickel
Doris Nagel
Rasmus Worsøe Havmøller
Gennady F. Baryshnikov
Ulrich Joger
Wilfried Rosendahl
Michael Hofreiter
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
505
eng
uncontrolled
Ancient DNA
eng
uncontrolled
Hybridisation capture
eng
uncontrolled
Leopards
eng
uncontrolled
Mitochondrial genomes
eng
uncontrolled
Mitogenomes
eng
uncontrolled
mtDNA
eng
uncontrolled
Palaeogenetics
eng
uncontrolled
Panthera pardus
Biowissenschaften; Biologie
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/42255/pmnr505.pdf
43881
2015
2020
eng
284
295
12
908
postprint
1
2020-05-25
2020-05-25
--
The future of ancient DNA
Technological innovations such as next generation sequencing and DNA hybridisation enrichment have resulted in multi-fold increases in both the quantity of ancient DNA sequence data and the time depth for DNA retrieval. To date, over 30 ancient genomes have been sequenced, moving from 0.7x coverage (mammoth) in 2008 to more than 50x coverage (Neanderthal) in 2014. Studies of rapid evolutionary changes, such as the evolution and spread of pathogens and the genetic responses of hosts, or the genetics of domestication and climatic adaptation, are developing swiftly and the importance of palaeogenomics for investigating evolutionary processes during the last million years is likely to increase considerably. However, these new datasets require new methods of data processing and analysis, as well as conceptual changes in interpreting the results. In this review we highlight important areas of future technical and conceptual progress and discuss research topics in the rapidly growing field of palaeogenomics.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
technical advances and conceptual shifts
10.25932/publishup-43881
urn:nbn:de:kobv:517-opus4-438816
1866-8372
BioEssays 37 (2015) 3, 284-293 DOI: 10.1002/bies.201400160
<a href="http://publishup.uni-potsdam.de/39132">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Michael Hofreiter
Johanna L. A. Paijmans
Helen Goodchild
Camilla F. Speller
Axel Barlow
Gloria M. Gonzalez-Fortes
Jessica A. Thomas
Arne Ludwig
Matthew J. Collins
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
908
eng
uncontrolled
ancient DNA
eng
uncontrolled
hybridisation capture
eng
uncontrolled
multi-locus data
eng
uncontrolled
next generation sequencing (NGS)
eng
uncontrolled
palaeogenomics
eng
uncontrolled
population genomics
Chemie und zugeordnete Wissenschaften
Biowissenschaften; Biologie
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43881/pmnr908.pdf
44080
2017
2019
eng
8
793
postprint
1
2019-12-16
2019-12-16
--
A mitogenomic timetree for Darwin's enigmatic South American mammal Macrauchenia patachonica
The unusual mix of morphological traits displayed by extinct South American native ungulates (SANUs) confounded both Charles Darwin, who first discovered them, and Richard Owen, who tried to resolve their relationships. Here we report an almost complete mitochondrial genome for the litoptern Macrauchenia. Our dated phylogenetic tree places Macrauchenia as sister to Perissodactyla, but close to the radiation of major lineages within Laurasiatheria. This position is consistent with a divergence estimate of B66Ma (95% credibility interval, 56.64-77.83 Ma) obtained for the split between Macrauchenia and other Panperissodactyla. Combined with their morphological distinctiveness, this evidence supports the positioning of Litopterna (possibly in company with other SANU groups) as a separate order within Laurasiatheria. We also show that, when using strict criteria, extinct taxa marked by deep divergence times and a lack of close living relatives may still be amenable to palaeogenomic analysis through iterative mapping against more distant relatives.
Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-440801
10.25932/publishup-44080
1866-8372
online registration
Nature Communications 8 (2017) Art. 15951 DOI: 10.1038/ncomms15951
false
true
CC-BY - Namensnennung 4.0 International
Michael V. Westbury
Sina Isabelle Baleka
Axel Barlow
Stefanie Hartmann
Johanna L. A. Paijmans
Alejandro Kramarz
Analía M. Forasiepi
Mariano Bond
Javier N. Gelfo
Marcelo A. Reguero
Patricio López-Mendoza
Matias Taglioretti
Fernando Scaglia
Andrés Rinderknecht
Washington Jones
Francisco Mena
Guillaume Billet
Christian de Muizon
José Luis Aguilar
Ross D.E. MacPhee
Michael Hofreiter
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
793
eng
uncontrolled
ancient DNA
eng
uncontrolled
evolutionary history
eng
uncontrolled
genome sequence
eng
uncontrolled
reveals
eng
uncontrolled
contamination
eng
uncontrolled
alignment
eng
uncontrolled
reads
eng
uncontrolled
bones
Naturwissenschaften und Mathematik
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/44080/pmnr793.pdf
42815
2017
eng
7
715
postprint
1
--
--
--
Reduction of the contaminant fraction of DNA obtained from an ancient giant panda bone
Objective: A key challenge in ancient DNA research is massive microbial DNA contamination from the deposition site which accumulates post mortem in the study organism’s remains. Two simple and cost-effective methods to enrich the relative endogenous fraction of DNA in ancient samples involve treatment of sample powder with either bleach or Proteinase K pre-digestion prior to DNA extraction. Both approaches have yielded promising but vary-ing results in other studies. Here, we contribute data on the performance of these methods using a comprehensive and systematic series of experiments applied to a single ancient bone fragment from a giant panda (Ailuropoda melanoleuca).Results: Bleach and pre-digestion treatments increased the endogenous DNA content up to ninefold. However, the absolute amount of DNA retrieved was dramatically reduced by all treatments. We also observed reduced DNA damage patterns in pre-treated libraries compared to untreated ones, resulting in longer mean fragment lengths and reduced thymine over-representation at fragment ends. Guanine–cytosine (GC) contents of both mapped and total reads are consistent between treatments and conform to general expectations, indicating no obvious biasing effect of the applied methods. Our results therefore confirm the value of bleach and pre-digestion as tools in palaeog-enomic studies, providing sufficient material is available.
Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-428151
1866-8372
10.25932/publishup-42815
online registration
BMC Research Notes 10 (2017) Art. 754 DOI: 10.1186/s13104-017-3061-3
754
true
true
CC-BY - Namensnennung 4.0 International
Nikolas Basler
Georgios Xenikoudakis
Michael V. Westbury
Lingfeng Song
Guilian Sheng
Axel Barlow
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
715
eng
uncontrolled
ancient DNA (aDNA)
eng
uncontrolled
bleach
eng
uncontrolled
pre-digestion
eng
uncontrolled
endogenous content
eng
uncontrolled
palaeogenomics
eng
uncontrolled
paleogenomics
eng
uncontrolled
next generation sequencing (NGS)
eng
uncontrolled
giant panda
eng
uncontrolled
Ailuropoda melanoleuca
Biowissenschaften; Biologie
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
BioMed Central
Universität Potsdam
https://publishup.uni-potsdam.de/files/42815/pmnr715.pdf
42256
2018
2018
eng
12
156
18
article
BioMed Central und Springer
London, Berlin und Heidelberg
1
2018-10-23
2018-10-23
--
Historical biogeography of the leopard (Panthera pardus) and its extinct Eurasian populations
Background
Resolving the historical biogeography of the leopard (Panthera pardus) is a complex issue, because patterns inferred from fossils and from molecular data lack congruence. Fossil evidence supports an African origin, and suggests that leopards were already present in Eurasia during the Early Pleistocene. Analysis of DNA sequences however, suggests a more recent, Middle Pleistocene shared ancestry of Asian and African leopards. These contrasting patterns led researchers to propose a two-stage hypothesis of leopard dispersal out of Africa: an initial Early Pleistocene colonisation of Asia and a subsequent replacement by a second colonisation wave during the Middle Pleistocene. The status of Late Pleistocene European leopards within this scenario is unclear: were these populations remnants of the first dispersal, or do the last surviving European leopards share more recent ancestry with their African counterparts?
Results
In this study, we generate and analyse mitogenome sequences from historical samples that span the entire modern leopard distribution, as well as from Late Pleistocene remains. We find a deep bifurcation between African and Eurasian mitochondrial lineages (~ 710 Ka), with the European ancient samples as sister to all Asian lineages (~ 483 Ka). The modern and historical mainland Asian lineages share a relatively recent common ancestor (~ 122 Ka), and we find one Javan sample nested within these.
Conclusions
The phylogenetic placement of the ancient European leopard as sister group to Asian leopards suggests that these populations originate from the same out-of-Africa dispersal which founded the Asian lineages. The coalescence time found for the mitochondrial lineages aligns well with the earliest undisputed fossils in Eurasia, and thus encourages a re-evaluation of the identification of the much older putative leopard fossils from the region. The relatively recent ancestry of all mainland Asian leopard lineages suggests that these populations underwent a severe population bottleneck during the Pleistocene. Finally, although only based on a single sample, the unexpected phylogenetic placement of the Javan leopard could be interpreted as evidence for exchange of mitochondrial lineages between Java and mainland Asia, calling for further investigation into the evolutionary history of this subspecies.
BMC Evolutionary Biology
10.1186/s12862-018-1268-0
1471-2148
Universität Potsdam
PA 2018_58
1661.24
<a href="http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-422555">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 505</a>
CC-BY - Namensnennung 4.0 International
Johanna L. A. Paijmans
Axel Barlow
Daniel W. Förster
Kirstin Henneberger
Matthias Meyer
Birgit Nickel
Doris Nagel
Rasmus Worsøe Havmøller
Gennady F. Baryshnikov
Ulrich Joger
Wilfried Rosendahl
Michael Hofreiter
eng
uncontrolled
Ancient DNA
eng
uncontrolled
Hybridisation capture
eng
uncontrolled
Leopards
eng
uncontrolled
Mitochondrial genomes
eng
uncontrolled
Mitogenomes
eng
uncontrolled
mtDNA
eng
uncontrolled
Palaeogenetics
eng
uncontrolled
Panthera pardus
Biowissenschaften; Biologie
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Publikationsfonds der Universität Potsdam
Open Access