43514
2014
2020
eng
35
43
11
621
postprint
1
2020-04-16
2020-04-16
--
The effects of life stress and neural learning signals on fluid intelligence
Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account.
Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
10.25932/publishup-43514
urn:nbn:de:kobv:517-opus4-435140
1866-8372
European Archives of Psychiatry and Clinical Neuroscience 265 (2015) 35–43 DOI: 10.1007/s00406-014-0519-3
<a href="http://publishup.uni-potsdam.de/39219">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Eva Friedel
Florian Schlagenhauf
Anne Beck
Raymond J. Dolan
Quentin J. M. Huys
Michael Armin Rapp
Andreas Heinz
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
621
eng
uncontrolled
reinforcement learning
eng
uncontrolled
prediction error signal
eng
uncontrolled
ventral striatum
eng
uncontrolled
stress
eng
uncontrolled
intelligence
Medizin und Gesundheit
open_access
Humanwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43514/phr621.pdf
39219
2015
2015
eng
35
43
9
1
265
article
Springer
Heidelberg
1
--
--
--
The effects of life stress and neural learning signals on fluid intelligence
Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account.
European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry
10.1007/s00406-014-0519-3
25142177
0940-1334
1433-8491
wos:2015
WOS:000349012700005
Heinz, A (reprint author), Charite, Dept Psychiat & Psychotherapy, Campus Charite Mitte,Charite Pl 1, D-10117 Berlin, Germany., andreas.heinz@charite.de
German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) [FOR 1617, HE2597/13-1, RA1047/2-1, SM80/7-1]
<a href="https://doi.org/10.25932/publishup-43514">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 621</a>
Eva Friedel
Florian Schlagenhauf
Anne Beck
Raymond J. Dolan
Quentin J. M. Huys
Michael Armin Rapp
Andreas Heinz
eng
uncontrolled
Reinforcement learning
eng
uncontrolled
Prediction error signal
eng
uncontrolled
Ventral striatum
eng
uncontrolled
Stress
eng
uncontrolled
Intelligence
Referiert
Department Sport- und Gesundheitswissenschaften
Institut für Sportwissenschaft
39404
2015
2015
eng
331
341
11
2
232
article
Springer
New York
1
--
--
--
Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders
A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries.
We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment.
During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation.
Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.
Psychopharmacology
10.1007/s00213-014-3662-7
24973896
0033-3158
1432-2072
wos:2015
WOS:000348120700003
Hagele, C (reprint author), Charite, Dept Psychiat & Psychotherapy, Campus Charite Mitte,Charitepl 1, D-10117 Berlin, Germany., claudia.haegele@charite.de
German Research Foundation (Deutsche Forschungsgemeinschaft) [HE 2597/4-3, 7-3, 15-1 (FOR1617), EXC 257, SCHL1969/1-1, 2-1, STE-1430/6-1, WI709/10-1]; Bundesministerium fur Bildung und Forschung [01GQ0411, 01KR1207C, 01GS08159]
<a href="https://doi.org/10.25932/publishup-43106">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 653</a>
Claudia Haegele
Florian Schlagenhauf
Michael Armin Rapp
Philipp Sterzer
Anne Beck
Felix Bermpohl
Meline Stoy
Andreas Stroehle
Hans-Ulrich Wittchen
Raymond J. Dolan
Andreas Heinz
eng
uncontrolled
Dimensional
eng
uncontrolled
fMRI
eng
uncontrolled
Reward system
eng
uncontrolled
Ventral striatum
eng
uncontrolled
Monetary incentive delay task
eng
uncontrolled
Depressive symptoms
Referiert
Department Sport- und Gesundheitswissenschaften
Institut für Sportmedizin und Prävention
43106
2014
2020
eng
331
341
13
653
postprint
1
2020-09-01
2020-09-01
--
Dimensional psychiatry
A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries.
We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment.
We used functional magnetic resonance imaging (fMRI) and a monetary incentive delay (MID) task to study the functional correlates of reward anticipation across major psychiatric disorders in 184 subjects, with the diagnoses of alcohol dependence (n = 26), schizophrenia (n = 44), major depressive disorder (MDD, n = 24), bipolar disorder (acute manic episode, n = 13), attention deficit/hyperactivity disorder (ADHD, n = 23), and healthy controls (n = 54). Subjects' individual Beck Depression Inventory-and State-Trait Anxiety Inventory-scores were correlated with clusters showing significant activation during reward anticipation.
During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation.
Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.
Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
reward dysfunction and depressive mood across psychiatric disorders
10.25932/publishup-43106
urn:nbn:de:kobv:517-opus4-431064
1866-8364
online registration
Psychopharmacology 232 (2015) 331–341 DOI:10.1007/s00213-014-3662-7
<a href="http://publishup.uni-potsdam.de/39404">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
true
true
CC-BY - Namensnennung 4.0 International
Claudia Hägele
Florian Schlagenhauf
Michael Armin Rapp
Philipp Sterzer
Anne Beck
Felix Bermpohl
Meline Stoy
Andreas Ströhle
Hans-Ulrich Wittchen
Raymond J. Dolan
Andreas Heinz
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
653
eng
uncontrolled
dimensional
eng
uncontrolled
fMRI
eng
uncontrolled
reward system
eng
uncontrolled
ventral striatum
eng
uncontrolled
monetary incentive delay task
eng
uncontrolled
depressive symptoms
Datenverarbeitung; Informatik
Medizin und Gesundheit
open_access
Referiert
Department Sport- und Gesundheitswissenschaften
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43106/phr653.pdf
37913
2014
2014
eng
91S
92S
2
9
75
conferenceobject
Elsevier
New York
1
--
--
--
Reward expectation and affective responses across psychiatric disorders - A dimensional approach
Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry
0006-3223
1873-2402
wos:2014
69th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry
2014
WOS:000334101800285
New York, NY
Claudia Haegele
Eva Friedel
Florian Schlagenhauf
Philipp Sterzer
Anne Beck
Felix Bermpohl
Michael Armin Rapp
Meline Stoy
Andreas Stroehle
Raymond J. Dolan
Andreas Heinz
eng
uncontrolled
dimensional
eng
uncontrolled
transdiagnostic
eng
uncontrolled
reward system
eng
uncontrolled
ventral striatum
eng
uncontrolled
fMRI
Strukturbereich Kognitionswissenschaften
Referiert
Exzellenzbereich Kognitionswissenschaften