35934
2012
2012
eng
532
+
9
5
44
article
Nature Publ. Group
New York
Cohorts Heart Aging Res Genetic Ep, Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti
1
--
--
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Common variants at 12q15 and 12q24 are associated with infant head circumference
To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
Nature genetics
10.1038/ng.2238
1061-4036
wos:2011-2013
WOS:000303416300013
Smith, GD (reprint author), Univ Bristol, MRC, Ctr Causal Anal Translat Epidemiol, Sch Social & Community Med, Bristol, Avon, England., Julia.Mackay@bristol.ac.uk; heinrich@helmholtz-muenchen.de; m.jarvelin@imperial.ac.uk; v.jaddoe@erasmusmc.nl; heinrich@helmholtz-muenchen.de; v.jaddoe@erasmusmc.nl; m.jarvelin@imperial.ac.uk; heinrich@helmholtz-muenchen.de; v.jaddoe@erasmusmc.nl; m.jarvelin@imperial.ac.uk
Academy of Finland [104781, 120315, 129269, 1114194, 134839, 129287];
Biocentrum Helsinki; Biocenter, University of Oulu, Finland; British
Heart Foundation; Canadian Institutes of Health Research [MOP 82893];
The Children's Hospital of Philadelphia; Cotswold Foundation; Darlington
Trust; Dutch Asthma Foundation; Dutch Ministry of the Environment;
Erasmus Medical Center Rotterdam; Erasmus University Rotterdam; European
Community [HEALTH-F4-2007-201413]; Exeter National Health Service (NHS)
Research and Development; Fundacio La Marato de TV3 (Televisio de
Catalunya); Helmholtz Zentrum Muenchen; German Research Center for
Environment and Health; Institute of Epidemiology I; Neuherberg;
Instituto de Salud Carlos III [FIS PI081151, PS09/00432]; Institut fur
Umweltmedizinische Forschung (IUF) Dusseldorf; Marien-Hospital Wesel; UK
MRC [G0500539, G0600331, G0600705]; Municipal Health Service Rotterdam;
National Health and Medical Research Council of Australia [403981,
003209]; National Public Health Institute, Helsinki, Finland;
Netherlands Organisation for Scientific Research (NWO); Netherlands
Organisation for Health Research and Development (ZonMw) [SPI
56-464-14192, 904-61-090, 904-61-193, 912-03-031, 480-04-004,
400-05-717]; US NHLBI [5R01HL087679-02, 1RL1MH083268-01]; US NIH
[1R01HD056465-01A1]; Peninsula NIHR Clinical Research Facility; RAINE
Medical Research Foundation; Rotterdam Homecare Foundation; South West
NHS Research and Development; Stichting Astmabestrijding; Stichting
Trombosedienst & Artsenlaboratorium Rijnmond (STAR) Rotterdam; Technical
University Munich; Telethon Institute for Child Health Research;
UFZ-Centre for Environmental Research Leipzig-Halle; University Hospital
Oulu, Finland; University of Bristol; University of Leipzig; Wellcome
Trust [GR069224, 085541/Z/08/Z, WT083431MA, WT088431MA]; Western
Australian DNA Bank; Western Australian Genetic Epidemiology Resource;
ZonMW [21000074]; Dutch Kidney Foundation [C08.2251]; MRC UK [G0500539,
PS0476]; MRC [MRC G0800582]; Netherlands Organisation for Health
Research (ZonMw) [90700303, 916.10159]
H. Rob Taal
Beate St Pourcain
Elisabeth Thiering
Shikta Das
Dennis O. Mook-Kanamori
Nicole M. Warrington
Marika Kaakinen
Eskil Kreiner-Moller
Jonathan P. Bradfield
Rachel M. Freathy
Frank Geller
Monica Guxens
Diana L. Cousminer
Marjan Kerkhof
Nicholas J. Timpson
M. Arfan Ikram
Lawrence J. Beilin
Klaus Bonnelykke
Jessica L. Buxton
Pimphen Charoen
Bo Lund Krogsgaard Chawes
Johan Eriksson
David M. Evans
Albert Hofman
John P. Kemp
Cecilia E. Kim
Norman Klopp
Jari Lahti
Stephen J. Lye
George McMahon
Frank D. Mentch
Martina Mueller-Nurasyid
Paul F. O'Reilly
Inga Prokopenko
Fernando Rivadeneira
Eric A. P. Steegers
Jordi Sunyer
Carla Tiesler
Hanieh Yaghootkar
Monique M. B. Breteler
Stephanie Debette
Myriam Fornage
Vilmundur Gudnason
Lenore J. Launer
Aad van der Lugt
Thomas H. Mosley
Sudha Seshadri
Albert V. Smith
Meike W. Vernooij
Alexandra I. F. Blakemore
Rosetta M. Chiavacci
Bjarke Feenstra
Julio Fernandez-Banet
Struan F. A. Grant
Anna-Liisa Hartikainen
Albert J. van der Heijden
Carmen Iniguez
Mark Lathrop
Wendy L. McArdle
Anne Molgaard
John P. Newnham
Lyle J. Palmer
Aarno Palotie
Annneli Pouta
Susan M. Ring
Ulla Sovio
Marie Standl
Andre G. Uitterlinden
H-Erich Wichmann
Nadja Hawwa Vissing
Charles DeCarli
Cornelia M. van Duijn
Mark I. McCarthy
Gerard H. Koppelman
Xavier Estivill
Andrew T. Hattersley
Mads Melbye
Hans Bisgaard
Craig E. Pennell
Elisabeth Widen
Hakon Hakonarson
George Davey Smith
Joachim Heinrich
Marjo-Riitta Jarvelin
Vincent W. V. Jaddoe
Linda S. Adair
Wei Ang
Mustafa Atalay
Toos van Beijsterveldt
Nienke Bergen
Kelly Benke
Diane J. Berry
Jonathan P. Bradfield
Pimphen Charoen
Lachlan Coin
Diana L. Cousminer
Shikta Das
Oliver S. P. Davis
Paul Elliott
David M. Evans
Bjarke Feenstra
Claudia Flexeder
Tim Frayling
Rachel M. Freathy
Romy Gaillard
Frank Geller
Maria Groen-Blokhuis
Liang-Kee Goh
Monica Guxens
Claire M. A. Haworth
Dexter Hadley
Johannes Hebebrand
Anke Hinney
Joel N. Hirschhorn
John W. Holloway
Claus Holst
Jouke Jan Hottenga
Momoko Horikoshi
Ville Huikari
Elina Hypponen
Carmen Iniguez
Marika Kaakinen
Tuomas O. Kilpelainen
Mirna Kirin
Matthew Kowgier
Hanna-Maaria Lakka
Leslie A. Lange
Debbie A. Lawlor
Terho Lehtimaki
Alex Lewin
Cecilia Lindgren
Virpi Lindi
Reedik Maggi
Julie Marsh
Christel Middeldorp
Iona Millwood
Dennis O. Mook-Kanamori
Jeffrey C. Murray
Michel Nivard
Ellen Aagaard Nohr
Ioanna Ntalla
Emily Oken
Paul F. O'Reilly
Lyle J. Palmer
Kalliope Panoutsopoulou
Jennifer Pararajasingham
Inga Prokopenko
Alina Rodriguez
Rany M. Salem
Sylvain Sebert
Niina Siitonen
Ulla Sovio
Beate St Pourcain
David P. Strachan
Jordi Sunyer
H. Rob Taal
Yik-Ying Teo
Elisabeth Thiering
Carla Tiesler
Andre G. Uitterlinden
Beatriz Valcarcel
Nicole M. Warrington
Scott White
Gonneke Willemsen
Hanieh Yaghootkar
Eleftheria Zeggini
Dorret I. Boomsma
Cyrus Cooper
Xavier Estivill
Matthew Gillman
Struan F. A. Grant
Hakon Hakonarson
Andrew T. Hattersley
Joachim Heinrich
Berthold Hocher
Vincent W. V. Jaddoe
Marjo-Riitta Jarvelin
Timo A. Lakka
Mark I. McCarthy
Mads Melbye
Karen L. Mohlke
George V. Dedoussis
Ken K. Ong
Ewan R. Pearson
Craig E. Pennell
Thomas S. Price
Chris Power
Olli T. Raitakari
Seang-Mei Saw
Andre Scherag
Olli Simell
Thorkild I. A. Sorensen
Nicholas J. Timpson
Elisabeth Widen
James F. Wilson
Wei Ang
Toos van Beijsterveldt
Nienke Bergen
Kelly Benke
Diane J. Berry
Jonathan P. Bradfield
Pimphen Charoen
Lachlan Coin
Diana L. Cousminer
Shikta Das
Paul Elliott
David M. Evans
Tim Frayling
Rachel M. Freathy
Romy Gaillard
Maria Groen-Blokhuis
Monica Guxens
Dexter Hadley
Jouke Jan Hottenga
Ville Huikari
Elina Hypponen
Marika Kaakinen
Matthew Kowgier
Debbie A. Lawlor
Alex Lewin
Cecilia Lindgren
Julie Marsh
Christel Middeldorp
Iona Millwood
Dennis O. Mook-Kanamori
Michel Nivard
Paul F. O'Reilly
Lyle J. Palmer
Inga Prokopenko
Alina Rodriguez
Sylvain Sebert
Ulla Sovio
Beate St Pourcain
Marie Standl
David P. Strachan
Jordi Sunyer
H. Rob Taal
Elisabeth Thiering
Carla Tiesler
Andre G. Uitterlinden
Beatriz Valcarcel
Nicole M. Warrington
Scott White
Gonneke Willemsen
Hanieh Yaghootkar
Dorret I. Boomsma
Xavier Estivill
Struan F. A. Grant
Hakon Hakonarson
Andrew T. Hattersley
Joachim Heinrich
Vincent W. V. Jaddoe
Marjo-Riitta Jarvelin
Mark I. McCarthy
Craig E. Pennell
Chris Power
Nicholas J. Timpson
Elisabeth Widen
M. Arfan Ikram
Myriam Fornage
Albert V. Smith
Sudha Seshadri
Reinhold Schmidt
Stephanie Debette
Henri A. Vrooman
Sigurdur Sigurdsson
Stefan Ropele
Laura H. Coker
W. T. Longstreth
Wiro J. Niessen
Anita L. DeStefano
Alexa Beiser
Alex P. Zijdenbos
Maksim Struchalin
Clifford R. Jack
Mike A. Nalls
Rhoda Au
Albert Hofman
Haukur Gudnason
Aad van der Lugt
Tamara B. Harris
William M. Meeks
Meike W. Vernooij
Mark A. van Buchem
Diane Catellier
Vilmundur Gudnason
B. Gwen Windham
Philip A. Wolf
Cornelia M. van Duijn
Thomas H. Mosley
Helena Schmidt
Lenore J. Launer
Monique M. B. Breteler
Charles DeCarli
Institut für Biochemie und Biologie
Referiert
49661
2019
2019
eng
804
+
17
5
51
article
Nature Publ. Group
New York
EGG Consortium
1
2019-05-01
2019-05-01
--
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Nature genetics
31043758
1061-4036
1546-1718
wos:2019
WOS:000466842000008
Evans, DM (reprint author), Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia.; Freathy, RM (reprint author), Univ Exeter, Inst Biomed & Clin Sci, Royal Devon & Exeter Hosp, Coll Med & Hlth, Exeter, Devon, England.; Evans, DM; Freathy, RM (reprint author), Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.; Evans, DM (reprint author), Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England., d.evans1@uq.edu.au; r.freathy@ex.ac.uk
Diabetes UKDiabetes UK [17/0005594]; European Research CouncilEuropean Research Council (ERC) [323195]; Medical Research CouncilMedical Research Council UK (MRC) [MC_PC_15018, MC_UU_12011/4, MC_UU_00011/6, MC_UU_12013/4, MR/M005070/1, MR/J012165/1, MC_UU_00011/1, G9815508, G0601261, MC_UU_00011/5, MC_UP_A620_1017, MC_UU_12015/1, MC_UU_12013/3, G1001357]; NIEHS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [R01 ES022223, R21 ES028226, R24 ES028507, P30 ES019776, P30 ES023515, R01 ES029212]; Wellcome TrustWellcome Trust [202802, 104150, 098395, 205915, 098381, 212259, 088806]
2021-02-25T12:53:57+00:00
sword
importub
filename=package.tar
84117ccb625356b05295ebe98606c698
Evans, David M.
Freathy, Rachel M.
Nicole Warrington
Robin Beaumont
Momoko Horikoshi
Felix R. Day
Øyvind Helgeland
Charles Laurin
Jonas Bacelis
Shouneng Peng
Ke Hao
Bjarke Feenstra
Andrew R. Wood
Anubha Mahajan
Jessica Tyrrell
Neil R. Robertson
N. William Rayner
Zhen Qiao
Gunn-Helen Moen
Marc Vaudel
Carmen Marsit
Jia Chen
Michael Nodzenski
Theresia M. Schnurr
Mohammad Hadi Zafarmand
Jonathan P. Bradfield
Niels Grarup
Marjolein N. Kooijman
Ruifang Li-Gao
Frank Geller
Tarunveer Singh Ahluwalia
Lavinia Paternoster
Rico Rueedi
Ville Huikari
Jouke-Jan Hottenga
Leo-Pekka Lyytikäinen
Alana Cavadino
Sarah Metrustry
Diana L. Cousminer
Ying Wu
Elisabeth Paula Thiering
Carol A. Wang
Christian Theil Have
Natalia Vilor-Tejedor
Peter K. Joshi
Jodie N. Painter
Ioanna Ntalla
Ronny Myhre
Niina Pitkänen
Elisabeth M. van Leeuwen
Raimo Joro
Vasiliki Lagou
Rebecca C. Richmond
Ana Espinosa
Sheila J. Barton
Hazel M. Inskip
John W. Holloway
Loreto Santa-Marina
Xavier Estivill
Wei Ang
Julie A. Marsh
Christoph Reichetzeder
Letizia Marullo
Berthold Hocher
Kathryn L. Lunetta
Joanne M. Murabito
Caroline L. Relton
Manolis Kogevinas
Leda Chatzi
Catherine Allard
Luigi Bouchard
Marie-France Hivert
Ge Zhang
Louis J. Muglia
Jani Heikkinen
Camilla S. Morgen
Antoine H. C. van Kampen
Barbera D. C. van Schaik
Frank D. Mentch
Claudia Langenberg
Robert A. Scott
Jing Hua Zhao
Gibran Hemani
Susan M. Ring
Amanda J. Bennett
Kyle J. Gaulton
Juan Fernandez-Tajes
Natalie R. van Zuydam
Carolina Medina-Gomez
Hugoline G. de Haan
Frits R. Rosendaal
Zoltán Kutalik
Pedro Marques-Vidal
Shikta Das
Gonneke Willemsen
Hamdi Mbarek
Martina Müller-Nurasyid
Marie Standl
Emil V. R. Appel
Cilius Esmann Fonvig
Caecilie Trier
Catharina E. M. van Beijsterveldt
Mario Murcia
Mariona Bustamante
Sílvia Bonàs-Guarch
David M. Hougaard
Josep M. Mercader
Allan Linneberg
Katharina E. Schraut
Penelope A. Lind
Sarah Elizabeth Medland
Beverley M. Shields
Bridget A. Knight
Jin-Fang Chai
Kalliope Panoutsopoulou
Meike Bartels
Friman Sánchez
Jakob Stokholm
David Torrents
Rebecca K. Vinding
Sara M. Willems
Mustafa Atalay
Bo L. Chawes
Peter Kovacs
Inga Prokopenko
Marcus A. Tuke
Hanieh Yaghootkar
Katherine S. Ruth
Samuel E. Jones
Po-Ru Loh
Anna Murray
Michael N. Weedon
Anke Tönjes
Michael Stumvoll
Kim Fleischer Michaelsen
Aino-Maija Eloranta
Timo A. Lakka
Cornelia M. van Duijn
Wieland Kiess
Antje Koerner
Harri Niinikoski
Katja Pahkala
Olli T. Raitakari
Bo Jacobsson
Eleftheria Zeggini
George V. Dedoussis
Yik-Ying Teo
Seang-Mei Saw
Grant W. Montgomery
Harry Campbell
James F. Wilson
Tanja G. M. Vrijkotte
Martine Vrijheid
Eco J. C. N. de Geus
M. Geoffrey Hayes
Haja N. Kadarmideen
Jens-Christian Holm
Lawrence J. Beilin
Craig E. Pennell
Joachim Heinrich
Linda S. Adair
Judith B. Borja
Karen L. Mohlke
Johan G. Eriksson
Elisabeth E. Widen
Andrew T. Hattersley
Tim D. Spector
Mika Kaehoenen
Jorma S. Viikari
Terho Lehtimaeki
Dorret I. Boomsma
Sylvain Sebert
Peter Vollenweider
Thorkild I. A. Sorensen
Hans Bisgaard
Klaus Bonnelykke
Jeffrey C. Murray
Mads Melbye
Ellen A. Nohr
Dennis O. Mook-Kanamori
Fernando Rivadeneira
Albert Hofman
Janine F. Felix
Vincent W. V. Jaddoe
Torben Hansen
Charlotta Pisinger
Allan A. Vaag
Oluf Pedersen
Andre G. Uitterlinden
Marjo-Riitta Jarvelin
Christine Power
Elina Hypponen
Denise M. Scholtens
William L. Lowe
George Davey Smith
Nicholas J. Timpson
Andrew P. Morris
Nicholas J. Wareham
Hakon Hakonarson
Struan F. A. Grant
Timothy M. Frayling
Debbie A. Lawlor
Pal R. Njolstad
Stefan Johansson
Ken K. Ong
Mark I. McCarthy
John R. B. Perry
David M. Evans
Rachel M. Freathy
Institut für Ernährungswissenschaft
Referiert
Import
Green Open-Access
50042
2019
2019
eng
279
300
22
3
34
article
Springer
Dordrecht
EArly Genetics Lifecourse EGG Consortium EGG Membership EAGLE Membership
1
--
2019-03-18
--
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
European journal of epidemiology
design, results and future prospects
10.1007/s10654-019-00502-9
30887376
0393-2990
1573-7284
wos:2019
WOS:000463834200009
Middeldorp, CM (reprint author), Univ Queensland, Child Hlth Res Ctr, Brisbane, Qld, Australia., c.middeldorp@uq.edu.au
the Marie Sklodowska-Curie grantEuropean Union (EU) [721567]; European Sir Henry Dale Fellowship (Wellcome Trust); Sir Henry Dale Fellowship (Royal Society) [WT104150]; American Diabetes AssociationAmerican Diabetes Association [1-17-PDF-077]; Dutch Science Organization (ZonMW-VENI Grant) [916.14.023]; Australian National Health and Medical Research Council Early Career FellowshipNational Health and Medical Research Council of Australia [APP1104818]; Gene-Diet Interactions in Obesity (GENDINOB) project; National Institute of Health ResearchNational Institute for Health Research (NIHR); European Research CouncilEuropean Research Council (ERC) [323195 SZ-245 Endowed Chair in Genomic Research; National Institute for Health Research (NIHR) Senior Investigator AwardNational Institute for Health Research (NIHR) [NF-SI-0611-10219]; German Research Society, German Ministry of Education and Research; American Diabetes Association (ADA) Pathway Program Accelerator Early Investigator Award [1-15-ACE-26]; Helse Vest [23929]; Bergen Forskningsstiftelse; KG Jebsen Foundation; University of Bergen; Academy of Finland Research Professor programAcademy of Finland [265240, 263278]; University of Queensland Development Fellowship [UQFEL1718945]; Li Ka Shing Foundation; WT-SSI/John Fell funds; NIHR Biomedical Research Centre, OxfordNational Institute for Health Research (NIHR); Widenlife; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [5P50HD028138-27]; NHMRC Senior Reseach FellowshipNational Health and Medical Research Council of Australia [APP1103623]; career development fellowship [20308]; Wellcome TrustWellcome Trust [WT098395, WT098051, WT205915, 098051]; National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children Horizon 2020 research; European Union FP7-IDEAS-ERC Advanced Grant (GEPIDIAB) [ERC-AG -ERC-294785]; European Union FP7-IDEAS-ERC innovation programme (DYNAhealth) [H2020-PHC-2014-633595]; CRUKCancer Research UK [C18281/A19169]; NHMRC Practitioner Fellowship GrantNational Health and Medical Research Council of Australia [APP1105807]; European Regional Development Fund (ERDF)European Union (EU); European Social Fund (ESF)European Social Fund (ESF); Convergence Programme for Cornwall; Isles of Scilly; Diabetes Research and Wellness Foundation Non-Clinical de Recerca Agaur (AGAUR)Generalitat de Catalunya [2015 FI_B 00636]; ZonMWNetherlands Organization for Health Research and Development [TOP 40-00812-98-11010]; MRC Human Genetics Unit quinquennial programme "QTL in Health and Disease"; Diabetes UK RD Lawrence fellowshipDiabetes UK [17/0005594]; BBMRI-NL [CP2013-50]; Novo Nordisk FoundationNovo Nordisk Foundation [12955]; Oak Foundation Fellowship; European Research Council (ERC)European Research Council (ERC); KG Jebsen; European Research (FP/2007-2013)/ERC Grant [669545]; US National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 DK10324]; UK Medical Research CouncilMedical Research Council UK (MRC) [MC_UU_00011/6]; Wellcome Trust GWAS grantWellcome Trust [WT088806]; NIHR Senior Investigator Award [NF-SI-0611-10196]; NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol; UK Medical Research Council Unit [MC_UU_12013_5, MC_UU_12013_4]; University of Bristol NIHR Biomedical Research Centre (BRC) [202802/Z/16/Z, WT 102215/2/13/2]; CRUK Integrative Cancer Epidemiology Programme [C18281/A19169]; Netherlands Organization for Health Research and Development (NWO)Netherlands Organization for Scientific Research (NWO)Netherlands Organization for Health Research and Development [ZonMw-VIDI 016.136.361]; European Research Council Consolidator GrantEuropean Research Council (ERC) [ERC-2014-CoG-648916]; Australian Research Council Future FellowshipAustralian Research Council [FT130101709]; NHMRC Senior Research FellowshipNational Health and Medical Research Council of Australia [GNT1137714]; Daniel B. Burke Endowed Chair for Diabetes Research; Spinozapremie [NWO-56-464-14192]; Royal Netherlands Academy of Science Professor Award [PAH/6635]; NIHRNational Institute for Health Research (NIHR) [NF-SI-0617-10090]; Wellcome [090532, 098381, 203141]; [R01 HD056465]
2021-03-23T09:32:47+00:00
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Middeldorp, Christel M.
McCarthy, Mark I.
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Christel M. Middeldorp
Anubha Mahajan
Momoko Horikoshi
Neil R. Robertson
Robin N. Beaumont
Jonathan P. Bradfield
Mariona Bustamante
Diana L. Cousminer
Felix R. Day
N. Maneka De Silva
Monica Guxens
Dennis O. Mook-Kanamori
Beate St Pourcain
Nicole M. Warrington
Linda S. Adair
Emma Ahlqvist
Tarunveer Singh Ahluwalia
Peter Almgren
Wei Ang
Mustafa Atalay
Juha Auvinen
Meike Bartels
Jacques S. Beckmann
Jose Ramon Bilbao
Tom Bond
Judith B. Borja
Alana Cavadino
Pimphen Charoen
Zhanghua Chen
Lachlan Coin
Cyrus Cooper
John A. Curtin
Adnan Custovic
Shikta Das
Gareth E. Davies
George V. Dedoussis
Liesbeth Duijts
Peter R. Eastwood
Anders U. Eliasen
Paul Elliott
Johan G. Eriksson
Xavier Estivill
Joao Fadista
Iryna O. Fedko
Timothy M. Frayling
Romy Gaillard
W. James Gauderman
Frank Geller
Frank Gilliland
Vincente Gilsanz
Raquel Granell
Niels Grarup
Leif Groop
Dexter Hadley
Hakon Hakonarson
Torben Hansen
Catharina A. Hartman
Andrew T. Hattersley
M. Geoffrey Hayes
Johannes Hebebrand
Joachim Heinrich
Oyvind Helgeland
Anjali K. Henders
John Henderson
Tine B. Henriksen
Joel N. Hirschhorn
Marie-France Hivert
Berthold Hocher
John W. Holloway
Patrick Holt
Jouke-Jan Hottenga
Elina Hypponen
Carmen Iniguez
Stefan Johansson
Astanand Jugessur
Mika Kahonen
Heidi J. Kalkwarf
Jaakko Kaprio
Ville Karhunen
John P. Kemp
Marjan Kerkhof
Gerard H. Koppelman
Antje Korner
Sailesh Kotecha
Eskil Kreiner-Moller
Benard Kulohoma
Ashish Kumar
Zoltan Kutalik
Jari Lahti
Joan M. Lappe
Henrik Larsson
Terho Lehtimaki
Alexandra M. Lewin
Jin Li
Paul Lichtenstein
Cecilia M. Lindgren
Virpi Lindi
Allan Linneberg
Xueping Liu
Jun Liu
William L. Lowe
Sebastian Lundstrom
Leo-Pekka Lyytikainen
Ronald C. W. Ma
Aurelien Mace
Reedik Magi
Per Magnus
Abdullah A. Mamun
Minna Mannikko
Nicholas G. Martin
Hamdi Mbarek
Nina S. McCarthy
Sarah E. Medland
Mads Melbye
Erik Melen
Karen L. Mohlke
Claire Monnereau
Camilla S. Morgen
Andrew P. Morris
Jeffrey C. Murray
Ronny Myhre
Jackob M. Najman
Michel G. Nivard
Ellen A. Nohr
Ilja M. Nolte
Ioanna Ntalla
Sharon E. Oberfield
Emily Oken
Albertine J. Oldehinkel
Katja Pahkala
Teemu Palviainen
Kalliope Panoutsopoulou
Oluf Pedersen
Craig E. Pennell
Goran Pershagen
Niina Pitkanen
Robert Plomin
Christine Power
Rashmi B. Prasad
Inga Prokopenko
Lea Pulkkinen
Katri Raikkonen
Olli T. Raitakari
Rebecca M. Reynolds
Rebecca C. Richmond
Fernando Rivadeneira
Alina Rodriguez
Richard J. Rose
Rany Salem
Loreto Santa-Marina
Seang-Mei Saw
Theresia M. Schnurr
James G. Scott
Saskia Selzam
John A. Shepherd
Angela Simpson
Line Skotte
Patrick M. A. Sleiman
Harold Snieder
Thorkild I. A. Sorensen
Marie Standl
Eric A. P. Steegers
David P. Strachan
Leon Straker
Timo Strandberg
Michelle Taylor
Yik-Ying Teo
Elisabeth Thiering
Maties Torrent
Jessica Tyrrell
Andre G. Uitterlinden
Toos van Beijsterveldt
Peter J. van der Most
Cornelia M. van Duijn
Jorma Viikari
Natalia Vilor-Tejedor
Suzanne Vogelezang
Judith M. Vonk
Tanja G. M. Vrijkotte
Eero Vuoksimaa
Carol A. Wang
William J. Watkins
H-Erich Wichmann
Gonneke Willemsen
Gail M. Williams
James F. Wilson
Naomi R. Wray
Shujing Xu
Cheng-Jian Xu
Hanieh Yaghootkar
Lu Yi
Mohammad Hadi Zafarmand
Eleftheria Zeggini
Babette S. Zemel
Anke Hinney
Timo A. Lakka
Andrew J. O. Whitehouse
Jordi Sunyer
Elisabeth E. Widen
Bjarke Feenstra
Sylvain Sebert
Bo Jacobsson
Pal R. Njolstad
Camilla Stoltenberg
George Davey Smith
Debbie A. Lawlor
Lavinia Paternoster
Nicholas J. Timpson
Ken K. Ong
Hans Bisgaard
Klaus Bonnelykke
Vincent W. V. Jaddoe
Henning Tiemeier
Marjo-Riitta Jarvelin
David M. Evans
John R. B. Perry
Struan F. A. Grant
Dorret I. Boomsma
Rachel M. Freathy
Mark I. McCarthy
Janine F. Felix
eng
uncontrolled
Genetics
eng
uncontrolled
Consortium
eng
uncontrolled
Childhood traits and disorders
eng
uncontrolled
Longitudinal
Biowissenschaften; Biologie
Institut für Biochemie und Biologie
Referiert
Import
Hybrid Open-Access
35420
2013
2013
eng
76
U115
10
1
45
article
Nature Publ. Group
New York
MAGIC, Early Growth Genetics EGG
1
--
--
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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Nature genetics
10.1038/ng.2477
1061-4036
wos:2011-2013
WOS:000312838800016
McCarthy, MI (reprint author), Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England., mark.mccarthy@drl.ox.ac.uk; grants@chop.edu; v.jaddoe@erasmusmc.nl; m.jarvelin@imperial.ac.uk; n.j.timpson@bristol.ac.uk; ingap@well.ox.ac.uk; rachel.freathy@pms.ac.uk
Academy of Finland [126925, 121584, 124282, 129378, 117787, 41071,
209072, 129255, 104781, 120315, 129269, 1114194, 206374, 251360,
139900/24300796]; Biocentrum Helsinki; Arthritis Research UK; Augustinus
Foundation; Biobanking and Biomolecular Resources Research
Infrastructure (BBMRI-NL); Biomedical Research Council, Singapore [BMRC
06/1/21/19/466]; BIF: Boehringer Ingelheim Fonds; British Heart
Foundation; C.G. Sundell Foundation; Canadian Institutes of Health
Research [MOP-82893]; Cancer Research UK; Chief Scientist Office of the
Scottish Government; Children's Hospital of Philadelphia (Institute
Development Award); Conselleria de Sanitat Generalitat Valenciana;
Copenhagen Graduate School of Health Sciences; Cotswold Foundation
(Research Development Award); Curtin University and Women and Infants
Research Foundation; Danish Health Insurance Societies (Health Fund);
Danish Medical Research Council; Danish National Research Foundation;
Danish Pediatric Asthma Centre; Danish Pharmacists' Fund; Danish
Strategic Research Council; Darlington Trust; Department of Health and
Social Services in Northern Ireland; Deutsche Forschungsgemeinschaft
(DFG); Diabetes Hilfs-und Forschungsfonds Deutschland (DHFD); Diabetes
UK [RD08/0003704, RD08/0003692]; Dunhill Medical Trust; Dutch Asthma
Foundation [3.4.01.26, 3.2.06.022, 3.4.09.081, 3.2.10.085CO]; Dutch
Ministry of the Environment (EFRE); Europaische Fonds fur Regionale
Entwicklung (LIFE Child Obesity); Egmont Foundation; Else
Kroner-Fresenius Foundation; Emil Aaltonen Foundation; ENGAGE project
[HEALTH-F4-2007-201413]; Erasmus Medical Center; Erasmus University,
Rotterdam; European Commission [QLG1-CT-2000-01643, 018996,
LSHG-CT-2006-018947, FOOD-CT-2005-007034]; European Research Council
(ERC Advanced) [230374]; European Science Foundation (ESF)
[EU/QLRT-2001-01254]; Exeter NHS Research and Development; Faculty of
Biology and Medicine of Lausanne; Finnish Foundation of Cardiovascular
Research; Finnish Cultural Foundation; Finnish Innovation Fund Sitra;
Finnish Ministry of Education and Culture; Finnish Ministry of Social
Affairs and Health; Finnish Social Insurance Institution; Foundation for
Paediatric Research; Fundacio La Marato de TV3; Fundacion Roger Torne;
Generalitat de Catalunya-Interminesterial Council for Research and
Technological Innovation (CIRIT) [(1999SGR) 00241]; German Diabetes
Association; German Bundesministerium fuer Forschung und Technology [01
AK 803 A-H, 01 IG 07015 G]; German Research Foundation for the Clinical
Research Group Atherobesity [KO3512/1]; GlaxoSmithKline; Hagedorn
Research Institute; Instituto de Salud Carlos III [CB06/02/0041, FIS
PI041436, PI081151, PI041705, PS09/00432, FISFEDER 03/1615, 04/1509,
04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647];
Interdisciplinary Centre for Clinical Research at the University of
Leipzig [B27]; Integrated Research and Treatment Centre (IFB) Adiposity
Diseases; Jackstadt-Foundation; Juho Vainio Foundation; Juvenile
Diabetes Research Foundation International (JDRF); Kuopio, Tampere and
Turku University Hospital Medical Funds [5031343, 9M048]; Lundbeck
Foundation; Lundbeck Foundation Centre of Applied Medical Genomics for
Personalized Disease Prediction, Prevention and Care (LuCAMP); March of
Dimes Birth Defects Foundation [6-FY09-507]; MRC, UK [74882, G0000934,
G0601653, G0500539, G0600705, G0601261, G0600331, PrevMetSyn/SALVE
PS0476, MC-A760-5QX00]; Munich Center of Health Sciences (MC Health);
National Health and Medical Research Council of Australia [403981,
003209]; US National Human Genome Research Institute; US National
Institute of Allergy and Infectious Diseases; US National Institute of
Child Health and Human Development; US National Institute of Diabetes
and Digestive and Kidney Diseases (NIDDK); US National Institutes of
Health [U01DK062418, U01HG004423, U01HG004446, U01HG004438, R01DK075787,
1R01HD056465-01A, R01D0042157-01A, DK078150, TW05596, HL085144,
HD054501, RR20649, ES10126, DK56350]; Netherlands Bioinformatics Centre
(NBIC) BioAssist [RK/2008.024]; National Heart, Lung, and Blood
Institute (NHLBI) [5R01HL087679-02]; National Heart, Lung, and Blood
Institute (NHLBI) through the STAMPEED program [1RL1MH083268-01]; NIH
Genetic Association Information Network (GAIN); NIH/National Institute
of Mental Health (NIMH) [5R01MH63706: 02, MH081802]; Rutgers University
Cell and DNA Repository cooperative agreement [NIMH U24 MH068457-06];
Novo Nordisk Foundation Center for Basic Metabolic Research; Center for
Medical Systems Biology (CMSB; NWO Genomics); Netherlands Organization
for Scientific Research (NWO: Social Sciences (MaGW); Netherlands
Organization for Health Research and Development (ZonMw)
[Middelgroot-911-09-032, Spinozapremie 56-464-14192, 904-61-090,
904-61-193, 480-04-004, 400-05-717, Addiction-31160008, 985-10-002,
40-005698- 9032, 912-03-031]; Paavo Nurmi Foundation; Peninsula NIHR
Clinical Research Facility; Pharmacy Foundation of 1991; PhD School of
Molecular Metabolism University of Southern Denmark; Raine Medical
Research Foundation; Royal Society; Sigrid Juselius Foundation; South
West NHS Research and Development; Spanish Ministry of Science and
Innovation [SAF2008-00357]; Turku University Hospital; Swiss National
Science Foundation [33CSCO-122661]; Tampere Tuberculosis Foundation;
Telethon Institute for Child Health Research; Turku University
Foundation; US Centers for Disease Control and Prevention; University
Hospital Oulu, Biocenter, the University of Oulu [75617]; University of
Bristol; University of Potsdam; University of Southampton; University of
Western Australia (UWA); VU Institute for Health and Care Research
(EMGO+); Neuroscience Campus Amsterdam (NCA); Wellcome Trust [GR069224,
WT088806, 068545/Z/02, 076467, 085301, 090532, 083270, 083948,
085541/Z/08/Z, WT089549, WT083431MA]; Yrjo Jahnsson Foundation; Academy
of Finland (Center of Excellence in Complex Disease Genetics); Academy
of Finland (SALVE)
Momoko Horikoshi
Hanieh Yaghootkar
Dennis O. Mook-Kanamori
Ulla Sovio
H. Rob Taal
Branwen J. Hennig
Jonathan P. Bradfield
Beate St Pourcain
David M. Evans
Pimphen Charoen
Marika Kaakinen
Diana L. Cousminer
Terho Lehtimaki
Eskil Kreiner-Moller
Nicole M. Warrington
Mariona Bustamante
Bjarke Feenstra
Diane J. Berry
Elisabeth Thiering
Thiemo Pfab
Sheila J. Barton
Beverley M. Shields
Marjan Kerkhof
Elisabeth M. van Leeuwen
Anthony J. Fulford
Zoltan Kutalik
Jing Hua Zhao
Marcel den Hoed
Anubha Mahajan
Virpi Lindi
Liang-Kee Goh
Jouke-Jan Hottenga
Ying Wu
Olli T. Raitakari
Marie N. Harder
Aline Meirhaeghe
Ioanna Ntalla
Rany M. Salem
Karen A. Jameson
Kaixin Zhou
Dorota M. Monies
Vasiliki Lagou
Mirna Kirin
Jani Heikkinen
Linda S. Adair
Fowzan S. Alkuraya
Ali Al-Odaib
Philippe Amouyel
Ehm Astrid Andersson
Amanda J. Bennett
Alexandra I. F. Blakemore
Jessica L. Buxton
Jean Dallongeville
Shikta Das
Eco J. C. de Geus
Xavier Estivill
Claudia Flexeder
Philippe Froguel
Frank Geller
Keith M. Godfrey
Frederic Gottrand
Christopher J. Groves
Torben Hansen
Joel N. Hirschhorn
Albert Hofman
Mads V. Hollegaard
David M. Hougaard
Elina Hyppoenen
Hazel M. Inskip
Aaron Isaacs
Torben Jorgensen
Christina Kanaka-Gantenbein
John P. Kemp
Wieland Kiess
Tuomas O. Kilpelainen
Norman Klopp
Bridget A. Knight
Christopher W. Kuzawa
George McMahon
John P. Newnham
Harri Niinikoski
Ben A. Oostra
Louise Pedersen
Dirkje S. Postma
Susan M. Ring
Fernando Rivadeneira
Neil R. Robertson
Sylvain Sebert
Olli Simell
Torsten Slowinski
Carla M. T. Tiesler
Anke Toenjes
Allan Vaag
Jorma S. Viikari
Jacqueline M. Vink
Nadja Hawwa Vissing
Nicholas J. Wareham
Gonneke Willemsen
Daniel R. Witte
Haitao Zhang
Jianhua Zhao
James F. Wilson
Michael Stumvoll
Andrew M. Prentice
Brian F. Meyer
Ewan R. Pearson
Colin A. G. Boreham
Cyrus Cooper
Matthew W. Gillman
George V. Dedoussis
Luis A. Moreno
Oluf Pedersen
Maiju Saarinen
Karen L. Mohlke
Dorret I. Boomsma
Seang-Mei Saw
Timo A. Lakka
Antje Koerner
Ruth J. F. Loos
Ken K. Ong
Peter Vollenweider
Cornelia M. van Duijn
Gerard H. Koppelman
Andrew T. Hattersley
John W. Holloway
Berthold Hocher
Joachim Heinrich
Chris Power
Mads Melbye
Monica Guxens
Craig E. Pennell
Klaus Bonnelykke
Hans Bisgaard
Johan G. Eriksson
Elisabeth Widen
Hakon Hakonarson
Andre G. Uitterlinden
Anneli Pouta
Debbie A. Lawlor
George Davey Smith
Timothy M. Frayling
Mark I. McCarthy
Struan F. A. Grant
Vincent W. V. Jaddoe
Marjo-Riitta Jarvelin
Nicholas J. Timpson
Inga Prokopenko
Rachel M. Freathy
Institut für Ernährungswissenschaft
Referiert
35935
2012
2012
eng
539
+
7
5
44
article
Nature Publ. Group
New York
Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep
1
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Common variants at 6q22 and 17q21 are associated with intracranial volume
During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.
Nature genetics
10.1038/ng.2245
1061-4036
wos:2011-2013
WOS:000303416300014
Ikram, MA (reprint author), Univ Med Ctr, Erasmus Med Ctr, Dept Epidemiol, Rotterdam, Netherlands., m.a.ikram@erasmusmc.nl; cdecarli@ucdavis.edu
US National Institute on Aging (NIA) [N01-AG-12100]; US NHLBI
[N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020,
N01-HC-55021, N01-HC-55022, R01-HL087641, R01-HL093029]; National Human
Genome Research Institute [U01-HG004402]; NIH [HHSN268200625226C]; NIH
Roadmap for Medical Research [UL1RR025005]; Austrian Science Fond (FWF)
[P20545-P05, P13180]; Framingham Heart Study of the NHLBI
[N01-HC-25195]; Affymetrix, Inc [N02-HL-6-4278]; Robert Dawson Evans
Endowment of the Department of Medicine at Boston University School of
Medicine and Boston Medical Center; National Institute of Neurological
Disorders and Stroke [NS17950]; NHLBI [HL093029, 5R01HL087679-02,
1RL1MH083268-01]; NIA [AG08122, AG16495, AG033193, AG033040, AG031287,
P30AG013846]; Netherlands Organisation of Scientific Research (NWO)
[175.010.2005.011, 911-03-012]; Research Institute for Diseases in the
Elderly [014-93-015]; Netherlands Genomics Initiative (NGI)- NWO
[050-060-810]; Erasmus Medical Center; Erasmus University Organization
for Health Research and Development (ZonMw); Research Institute for
Diseases in the Elderly (RIDE); Ministry of Education, Culture and
Science; Ministry for Health, Welfare and Sports; European Commission
(DG XII); Municipality of Rotterdam; NWO [918-46-615, 904-61-096,
904-61-133, 948-00-010]; Nederlandse Hartstichting [2009B102];
Internationaal Parkinson Fonds; Academy of Finland [104781, 120315,
1114194]; University Hospital Oulu, Biocenter, University of Oulu;
ENGAGE; UK MRC [G0500539, 74882]; Wellcome Trust [GR069224, 076467];
Biocentrum Helsinki; Erasmus Medical Center, Rotterdam; Erasmus
University Rotterdam; Netherlands Organization for Health Research and
Development (ZonMw) [21000074, 90700303, 916.10159]; Dutch Kidney
Foundation [C08.2251]; Children's Hospital of Philadelphia; Cotswold
Foundation; US NIH [1R01HD056465-01A1]; Healthway Western Australia;
National Health and Medical Research Council of Australia [572613];
Canadian Institutes of Health Research [MOP 82893]; University of
Bristol; [HEALTH-F4-2007-201413]
M. Arfan Ikram
Myriam Fornage
Albert V. Smith
Sudha Seshadri
Reinhold Schmidt
Stephanie Debette
Henri A. Vrooman
Sigurdur Sigurdsson
Stefan Ropele
H. Rob Taal
Dennis O. Mook-Kanamori
Laura H. Coker
W. T. Longstreth
Wiro J. Niessen
Anita L. DeStefano
Alexa Beiser
Alex P. Zijdenbos
Maksim Struchalin
Clifford R. Jack
Fernando Rivadeneira
Andre G. Uitterlinden
David S. Knopman
Anna-Liisa Hartikainen
Craig E. Pennell
Elisabeth Thiering
Eric A. P. Steegers
Hakon Hakonarson
Joachim Heinrich
Lyle J. Palmer
Marjo-Riitta Jarvelin
Mark I. McCarthy
Struan F. A. Grant
Beate St Pourcain
Nicholas J. Timpson
George Davey Smith
Ulla Sovio
Mike A. Nalls
Rhoda Au
Albert Hofman
Haukur Gudnason
Aad van der Lugt
Tamara B. Harris
William M. Meeks
Meike W. Vernooij
Mark A. van Buchem
Diane Catellier
Vincent W. V. Jaddoe
Vilmundur Gudnason
B. Gwen Windham
Philip A. Wolf
Cornelia M. van Duijn
Thomas H. Mosley
Helena Schmidt
Lenore J. Launer
Monique M. B. Breteler
Charles DeCarli
Linda S. Adair
Wei Ang
Mustafa Atalay
Toos vanBeijsterveldt
Nienke Bergen
Kelly Benke
Diane J. Berry
Lachlan Coin
Oliver S. P. Davis
Paul Elliott
Claudia Flexeder
Tim Frayling
Romy Gaillard
Maria Groen-Blokhuis
Liang-Kee Goh
Claire M. A. Haworth
Dexter Hadley
Johannes Hebebrand
Anke Hinney
Joel N. Hirschhorn
John W. Holloway
Claus Holst
Jouke Jan Hottenga
Momoko Horikoshi
Ville Huikari
Elina Hypponen
Tuomas O. Kilpelainen
Mirna Kirin
Matthew Kowgier
Hanna-Maaria Lakka
Leslie A. Lange
Debbie A. Lawlor
Terho Lehtimaki
Alex Lewin
Cecilia Lindgren
Virpi Lindi
Reedik Maggi
Julie Marsh
Christel Middeldorp
Iona Millwood
Jeffrey C. Murray
Michel Nivard
Ellen Aagaard Nohr
Ioanna Ntalla
Emily Oken
Kalliope Panoutsopoulou
Jennifer Pararajasingham
Alina Rodriguez
Rany M. Salem
Sylvain Sebert
Niina Siitonen
David P. Strachan
Yik-Ying Teo
Beatriz Valcarcel
Gonneke Willemsen
Eleftheria Zeggini
Dorret I. Boomsma
Cyrus Cooper
Matthew Gillman
Berthold Hocher
Timo A. Lakka
Karen L. Mohlke
George V. Dedoussis
Ken K. Ong
Ewan R. Pearson
Thomas S. Price
Chris Power
Olli T. Raitakari
Seang-Mei Saw
Andre Scherag
Olli Simell
Thorkild I. A. Sorensen
James F. Wilson
Institut für Ernährungswissenschaft
Referiert
39159
2015
2015
eng
1155
1168
14
4
24
article
Oxford Univ. Press
Oxford
Early Genetics Lifecourse, Genetic Invest ANthropometric, Early Growth Genetics EGG
1
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--
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A novel common variant in DCST2 is associated with length in early life and height in adulthood
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
Human molecular genetics
10.1093/hmg/ddu510
25281659
0964-6906
1460-2083
wos:2015
WOS:000350138300021
Jaddoe, VWV (reprint author), Sophias Childrens Hosp, Erasmus Med Ctr, Dept Epidemiol, Generat Study Grp R, Postbus 2060, NL-3000 CB Rotterdam, Netherlands., v.jaddoe@erasmusmc.nl
Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust)
[085541/Z/08/Z]; Danish Council for Independent Research Medical
Sciences (FSS) The Alfred Benzon Foundation; Oak Foundation fellowship;
Wellcome Trust [090532]; European Research Council [SZ-245
50371-GLUCOSEGENES-FP7-IDEAS-ERC]; Netherlands Organization for Health
Research and Development [VIDI 016.136.367, VIDI 016.136.361]
Ralf J. P. van der Valk
Eskil Kreiner-Moller
Marjolein N. Kooijman
Monica Guxens
Evangelia Stergiakouli
Annika Saaf
Jonathan P. Bradfield
Frank Geller
M. Geoffrey Hayes
Diana L. Cousminer
Antje Koerner
Elisabeth Thiering
John A. Curtin
Ronny Myhre
Ville Huikari
Raimo Joro
Marjan Kerkhof
Nicole M. Warrington
Niina Pitkanen
Ioanna Ntalla
Momoko Horikoshi
Riitta Veijola
Rachel M. Freathy
Yik-Ying Teo
Sheila J. Barton
David M. Evans
John P. Kemp
Beate St Pourcain
Susan M. Ring
George Davey Smith
Anna Bergstrom
Inger Kull
Hakon Hakonarson
Frank D. Mentch
Hans Bisgaard
Bo Lund Krogsgaard Chawes
Jakob Stokholm
Johannes Waage
Patrick Eriksen
Astrid Sevelsted
Mads Melbye
Cornelia M. van Duijn
Carolina Medina-Gomez
Albert Hofman
Johan C. de Jongste
H. Rob Taal
Andre G. Uitterlinden
Loren L. Armstrong
Johan Eriksson
Aarno Palotie
Mariona Bustamante
Xavier Estivill
Juan R. Gonzalez
Sabrina Llop
Wieland Kiess
Anubha Mahajan
Claudia Flexeder
Carla M. T. Tiesler
Clare S. Murray
Angela Simpson
Per Magnus
Verena Sengpiel
Anna-Liisa Hartikainen
Sirkka Keinanen-Kiukaanniemi
Alexandra Lewin
Alexessander Da Silva Couto Alves
Alexandra I. F. Blakemore
Jessica L. Buxton
Marika Kaakinen
Alina Rodriguez
Sylvain Sebert
Marja Vaarasmaki
Timo Lakka
Virpi Lindi
Ulrike Gehring
Dirkje S. Postma
Wei Ang
John P. Newnham
Leo-Pekka Lyytikainen
Katja Pahkala
Olli T. Raitakari
Kalliope Panoutsopoulou
Eleftheria Zeggini
Dorret I. Boomsma
Maria Groen-Blokhuis
Jorma Ilonen
Lude Franke
Joel N. Hirschhorn
Tune H. Pers
Liming Liang
Jinyan Huang
Berthold Hocher
Mikael Knip
Seang-Mei Saw
John W. Holloway
Erik Melen
Struan F. A. Grant
Bjarke Feenstra
William L. Lowe
Elisabeth Widen
Elena Sergeyev
Harald Grallert
Adnan Custovic
Bo Jacobsson
Marjo-Riitta Jarvelin
Mustafa Atalay
Gerard H. Koppelman
Craig E. Pennell
Harri Niinikoski
George V. Dedoussis
Mark I. Mccarthy
Timothy M. Frayling
Jordi Sunyer
Nicholas J. Timpson
Fernando Rivadeneira
Klaus Bonnelykke
Vincent W. V. Jaddoe
Institut für Ernährungswissenschaft
Referiert