37044
2011
2011
eng
26
2
727
article
IOP Publ. Ltd.
Bristol
Fermi-LAT Collaboration, MAGIC Collaboration, VERITAS Collaboration
1
--
--
--
Insights into the high-energy gamma-Ray emission of markarian 501 fromextensive multifrequency observations in the fermi era
We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size less than or similar to 0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (similar or equal to 10(44) erg s(-1)) constitutes only a small fraction (similar to 10(-3)) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks. We find that the ultrarelativistic electrons and mildly relativistic protons within the blazar zone, if comparable in number, are in approximate energy equipartition, with their energy dominating the jet magnetic field energy by about two orders of magnitude.
The astrophysical journal : an international review of spectroscopy and astronomical physics
10.1088/0004-637X/727/2/129
0004-637X
wos:2011-2013
129
WOS:000286662000068
Paneque, D (reprint author), Stanford Univ, Dept Phys, WW Hansen Expt Phys Lab, Kavli Inst Particle Astrophys & Cosmol, Stanford, CA 94305 USA., dpaneque@mppmu.mpg.de; stawarz@astro.isas.jaxa.jp
K. A. Wallenberg Foundation; International Doctorate on Astroparticle
Physics (IDAPP) program; INFN Padova; Academy of Finland [212656,
210338]; National Radio Astronomy Observatory's Very Long Baseline Array
(VLBA) [BK150, BP143, MOJAVE]; Russian RFBR foundation [09-02-00092];
Georgian National Science Foundation [GNSF/ST07/4-180]; NASA
[NNX08AW31G]; NSF [AST-0808050]
A. A. Abdo
Margit Ackermann
M. Ajello
A. J. Allafort
L. Baldini
J. Ballet
G. Barbiellini
M. G. Baring
D. Bastieri
K. C. Bechtol
R. Bellazzini
B. Berenji
R. D. Blandford
E. D. Bloom
E. Bonamente
A. W. Borgland
A. Bouvier
T. J. Brandt
Johan Bregeon
A. Brez
M. Brigida
P. Bruel
R. Buehler
S. Buson
G. A. Caliandro
R. A. Cameron
A. Cannon
P. A. Caraveo
Svenja Carrigan
J. M. Casandjian
E. Cavazzuti
C. Cecchi
O. Celik
E. Charles
A. Chekhtman
C. C. Cheung
J. Chiang
S. Ciprini
R. Claus
J. Cohen-Tanugi
Jan Conrad
S. Cutini
C. D. Dermer
F. de Palma
E. do Couto e Silva
P. S. Drell
R. Dubois
D. Dumora
C. Favuzzi
S. J. Fegan
E. C. Ferrara
W. B. Focke
P. Fortin
M. Frailis
L. Fuhrmann
Y. Fukazawa
S. Funk
P. Fusco
F. Gargano
D. Gasparrini
N. Gehrels
S. Germani
N. Giglietto
F. Giordano
M. Giroletti
T. Glanzman
G. Godfrey
I. A. Grenier
L. Guillemot
S. Guiriec
M. Hayashida
E. Hays
D. Horan
R. E. Hughes
G. Johannesson
A. S. Johnson
W. N. Johnson
M. Kadler
T. Kamae
H. Katagiri
J. Kataoka
J. Knoedlseder
M. Kuss
J. Lande
L. Latronico
S. -H. Lee
M. Lemoine-Goumard
F. Longo
F. Loparco
B. Lott
M. N. Lovellette
P. Lubrano
G. M. Madejski
A. Makeev
W. Max-Moerbeck
Mario Nicola Mazziotta
J. E. McEnery
J. Mehault
P. F. Michelson
W. Mitthumsiri
T. Mizuno
A. A. Moiseev
C. Monte
M. E. Monzani
A. Morselli
I. V. Moskalenko
S. Murgia
M. Naumann-Godo
S. Nishino
P. L. Nolan
J. P. Norris
E. Nuss
T. Ohsugi
A. Okumura
N. Omodei
E. Orlando
J. F. Ormes
D. Paneque
J. H. Panetta
D. Parent
V. Pavlidou
T. J. Pearson
V. Pelassa
M. Pepe
M. Pesce-Rollins
F. Piron
T. A. Porter
S. Raino
R. Rando
M. Razzano
A. Readhead
A. Reimer
O. Reimer
J. L. Richards
J. Ripken
S. Ritz
M. Roth
H. F. -W. Sadrozinski
D. Sanchez
A. Sander
J. D. Scargle
C. Sgro
E. J. Siskind
P. D. Smith
G. Spandre
P. Spinelli
L. Stawarz
M. Stevenson
M. S. Strickman
K. V. Sokolovsky
D. J. Suson
H. Takahashi
T. Takahashi
T. Tanaka
J. B. Thayer
J. G. Thayer
D. J. Thompson
L. Tibaldo
F. Torres
G. Tosti
A. Tramacere
Y. Uchiyama
T. L. Usher
J. Vandenbroucke
V. Vasileiou
N. Vilchez
V. Vitale
A. P. Waite
P. Wang
A. E. Wehrle
B. L. Winer
K. S. Wood
Z. Yang
T. Ylinen
J. A. Zensus
M. Ziegler
J. Aleksic
L. A. Antonelli
P. Antoranz
Michael Backes
J. A. Barrio
J. Becerra Gonzalez
W. Bednarek
A. Berdyugin
K. Berger
E. Bernardini
A. Biland
O. Blanch Bigas
R. K. Bock
A. Boller
G. Bonnoli
Pol Bordas
D. Borla Tridon
Valentin Bosch-Ramon
D. Bose
I. Braun
T. Bretz
M. Camara
E. Carmona
A. Carosi
P. Colin
E. Colombo
J. L. Contreras
J. Cortina
S. Covino
F. Dazzi
A. de Angelis
E. De Cea del Pozo
B. De Lotto
M. De Maria
F. De Sabata
C. Delgado Mendez
A. Diago Ortega
M. Doert
A. Dominguez
Dijana Dominis Prester
D. Dorner
M. Doro
D. Elsaesser
D. Ferenc
M. V. Fonseca
L. Font
R. J. Garcia Lopen
M. Garczarczyk
M. Gaug
G. Giavitto
N. Godinovi
D. Hadasch
A. Herrero
D. Hildebrand
D. Hoehne-Moench
J. Hose
D. Hrupec
T. Jogler
S. Klepser
T. Kraehenbuehl
D. Kranich
J. Krause
A. La Barbera
E. Leonardo
E. Lindfors
S. Lombardi
M. Lopez
E. Lorenz
P. Majumdar
E. Makariev
G. Maneva
N. Mankuzhiyil
K. Mannheim
L. Maraschi
M. Mariotti
M. Martinez
D. Mazin
M. Meucci
J. M. Miranda
R. Mirzoyan
H. Miyamoto
J. Moldon
A. Moralejo
D. Nieto
K. Nilsson
R. Orito
I. Oya
R. Paoletti
J. M. Paredes
S. Partini
M. Pasanen
F. Pauss
R. G. Pegna
M. A. Perez-Torres
M. Persic
J. Peruzzo
J. Pochon
P. G. Prada Moroni
F. Prada
E. Prandini
N. Puchades
I. Puljak
T. Reichardt
R. Reinthal
W. Rhode
M. Ribo
J. Rico
M. Rissi
S. Ruegamer
A. Saggion
K. Saito
T. Y. Saito
M. Salvati
M. Sanchez-Conde
K. Satalecka
V. Scalzotto
V. Scapin
C. Schultz
T. Schweizer
M. Shayduk
S. N. Shore
A. Sierpowska-Bartosik
A. Sillanpaa
J. Sitarek
D. Sobczynska
F. Spanier
S. Spiro
A. Stamerra
B. Steinke
J. Storz
N. Strah
J. C. Struebig
T. Suric
L. O. Takalo
F. Tavecchio
P. Temnikov
T. Terzic
D. Tescaro
M. Teshima
H. Vankov
R. M. Wagner
Q. Weitzel
V. Zabalza
F. Zandanel
R. Zanin
V. A. Acciari
T. Arlen
T. Aune
W. Benbow
D. Boltuch
S. M. Bradbury
J. H. Buckley
V. Bugaev
A. Cannon
A. Cesarini
L. Ciupik
W. Cui
R. Dickherber
M. Errando
A. Falcone
J. P. Finley
G. Finnegan
L. Fortson
A. Furniss
N. Galante
D. Gall
G. H. Gillanders
S. Godambe
J. Grube
R. Guenette
G. Gyuk
D. Hanna
J. Holder
D. Huang
C. M. Hui
T. B. Humensky
P. Kaaret
N. Karlsson
M. Kertzman
D. Kieda
A. Konopelko
H. Krawczynski
F. Krennrich
M. J. Lang
G. Maier
S. McArthur
A. McCann
M. McCutcheon
P. Moriarty
R. Mukherjee
R. Ong
N. Otte
D. Pandel
J. S. Perkins
A. Pichel
M. Pohl
J. Quinn
K. Ragan
L. C. Reyes
P. T. Reynolds
E. Roache
H. J. Rose
A. C. Rovero
M. Schroedter
G. H. Sembroski
G. D. Senturk
D. Steele
S. P. Swordy
G. Tesic
M. Theiling
S. Thibadeau
A. Varlotta
S. Vincent
S. P. Wakely
J. E. Ward
T. C. Weekes
A. Weinstein
T. Weisgarber
D. A. Williams
M. Wood
B. Zitzer
M. Villata
C. M. Raiteri
H. D. Aller
M. F. Aller
A. A. Arkharov
D. A. Blinov
P. Calcidese
W. P. Chen
N. V. Efimova
G. Kimeridze
T. S. Konstantinova
E. N. Kopatskaya
E. Koptelova
O. M. Kurtanidze
S. O. Kurtanidze
A. Lahteenmaki
V. M. Larionov
E. G. Larionova
L. V. Larionova
R. Ligustri
D. A. Morozova
M. G. Nikolashvili
L. A. Sigua
I. S. Troitsky
E. Angelakis
M. Capalbi
A. Carraminana
L. Carrasco
P. Cassaro
E. de la Fuente
M. A. Gurwell
Y. Y. Kovalev
Yu. A. Kovalev
T. P. Krichbaum
H. A. Krimm
Paolo Leto
M. L. Lister
G. Maccaferri
J. W. Moody
Y. Mori
I. Nestoras
A. Orlati
C. Pagani
C. Pace
R. Pearson
M. Perri
B. G. Piner
A. B. Pushkarev
E. Ros
A. C. Sadun
T. Sakamoto
M. Tornikoski
Y. Yatsu
A. Zook
eng
uncontrolled
acceleration of particles
eng
uncontrolled
BL Lacertae objects: general
eng
uncontrolled
BL Lacertae objects: individual (Mrk 501)
eng
uncontrolled
galaxies: active
eng
uncontrolled
gamma rays: general
eng
uncontrolled
radiation mechanisms: non-thermal
Institut für Physik und Astronomie
Referiert
49198
2019
2019
eng
957
+
19
6
51
article
Nature Publ. Group
New York
Lifelines COHort Study
1
--
--
--
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Nature genetics
10.1038/s41588-019-0407-x
31152163
1061-4036
1546-1718
wos:2019
WOS:000469996900008
Kottgen, A (reprint author), Univ Freiburg, Fac Med, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany.; Kottgen, A (reprint author), Univ Freiburg, Med Ctr, Freiburg, Germany.; Kottgen, A (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.; Pattaro, C (reprint author), Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy., anna.koettgen@uniklinik-freiburg.de; cristian.pattaro@eurac.edu
Kowa; Sanofi; National Institute on Aging (NIA)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA); National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA; Michael J. Fox Foundation; University of California Healthcare - Nestle Nutrition (Nestec); Metagenics; AXA; GlaxoSmithKlineGlaxoSmithKline; MSD; EisaiEisai Inc; JanssenJohnson & Johnson USAJanssen Biotech Inc; Sanofi-AventisSanofi-Aventis; Eli LillyEli Lilly; National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA; Omthera Pharmaceuticals; Pfizer New ZealandPfizer; Elsai Inc.; Dalcor Pharma UK; CSL Behring; AstraZenecaAstraZeneca; BMSBristol-Myers Squibb; Boehringer-IngelheimBoehringer Ingelheim; PfizerPfizer; Roche Diagnostics - Johnson Johnson; NovartisNovartis; Novo NordiskNovo Nordisk; Gruenenthal
2021-02-01T13:29:01+00:00
sword
importub
filename=package.tar
360835c408d917ff8302d2644327371a
false
true
Matthias Wuttke
Yong Li
Man Li
Karsten B. Sieber
Mary F. Feitosa
Mathias Gorski
Adrienne Tin
Lihua Wang
Audrey Y. Chu
Anselm Hoppmann
Holger Kirsten
Ayush Giri
Jin-Fang Chai
Gardar Sveinbjornsson
Bamidele O. Tayo
Teresa Nutile
Christian Fuchsberger
Jonathan Marten
Massimiliano Cocca
Sahar Ghasemi
Yizhe Xu
Katrin Horn
Damia Noce
Peter J. Van der Most
Sanaz Sedaghat
Zhi Yu
Masato Akiyama
Saima Afaq
Tarunveer Singh Ahluwalia
Peter Almgren
Najaf Amin
Johan Arnlov
Stephan J. L. Bakker
Nisha Bansal
Daniela Baptista
Sven Bergmann
Mary L. Biggs
Ginevra Biino
Michael Boehnke
Eric Boerwinkle
Mathilde Boissel
Erwin Böttinger
Thibaud S. Boutin
Hermann Brenner
Marco Brumat
Ralph Burkhardt
Adam S. Butterworth
Eric Campana
Archie Campbell
Harry Campbell
Mickael Canouil
Robert J. Carroll
Eulalia Catamo
John C. Chambers
Miao-Ling Chee
Miao-Li Chee
Xu Chen
Ching-Yu Cheng
Yurong Cheng
Kaare Christensen
Renata Cifkova
Marina Ciullo
Maria Pina Concas
James P. Cook
Josef Coresh
Tanguy Corre
Cinzia Felicita Sala
Daniele Cusi
John Danesh
E. Warwick Daw
Martin H. De Borst
Alessandro De Grandi
Renee De Mutsert
Aiko P. J. De Vries
Frauke Degenhardt
Graciela Delgado
Ayse Demirkan
Emanuele Di Angelantonio
Katalin Dittrich
Jasmin Divers
Rajkumar Dorajoo
Kai-Uwe Eckardt
Georg Ehret
Paul Elliott
Karlhans Endlich
Michele K. Evans
Janine F. Felix
Valencia Hui Xian Foo
Oscar H. Franco
Andre Franke
Barry I. Freedman
Sandra Freitag-Wolf
Yechiel Friedlander
Philippe Froguel
Ron T. Gansevoort
He Gao
Paolo Gasparini
J. Michael Gaziano
Vilmantas Giedraitis
Christian Gieger
Giorgia Girotto
Franco Giulianini
Martin Gogele
Scott D. Gordon
Daniel F. Gudbjartsson
Vilmundur Gudnason
Toomas Haller
Pavel Hamet
Tamara B. Harris
Catharina A. Hartman
Caroline Hayward
Jacklyn N. Hellwege
Chew-Kiat Heng
Andrew A. Hicks
Edith Hofer
Wei Huang
Nina Hutri-Kahonen
Shih-Jen Hwang
M. Arfan Ikram
Olafur S. Indridason
Erik Ingelsson
Marcus Ising
Vincent W. V. Jaddoe
Johanna Jakobsdottir
Jost B. Jonas
Peter K. Joshi
Navya Shilpa Josyula
Bettina Jung
Mika Kahonen
Yoichiro Kamatani
Candace M. Kammerer
Masahiro Kanai
Mika Kastarinen
Shona M. Kerr
Chiea-Chuen Khor
Wieland Kiess
Marcus E. Kleber
Wolfgang Koenig
Jaspal S. Kooner
Antje Korner
Peter Kovacs
Aldi T. Kraja
Alena Krajcoviechova
Holly Kramer
Bernhard K. Kramer
Florian Kronenberg
Michiaki Kubo
Brigitte Kuhnel
Mikko Kuokkanen
Johanna Kuusisto
Martina La Bianca
Markku Laakso
Leslie A. Lange
Carl D. Langefeld
Jeannette Jen-Mai Lee
Benjamin Lehne
Terho Lehtimaki
Wolfgang Lieb
Su-Chi Lim
Lars Lind
Cecilia M. Lindgren
Jun Liu
Jianjun Liu
Markus Loeffler
Ruth J. F. Loos
Susanne Lucae
Mary Ann Lukas
Leo-Pekka Lyytikainen
Reedik Magi
Patrik K. E. Magnusson
Anubha Mahajan
Nicholas G. Martin
Jade Martins
Winfried Marz
Deborah Mascalzoni
Koichi Matsuda
Christa Meisinger
Thomas Meitinger
Olle Melander
Andres Metspalu
Evgenia K. Mikaelsdottir
Yuri Milaneschi
Kozeta Miliku
Pashupati P. Mishra
V. A. Million Veteran Program
Karen L. Mohlke
Nina Mononen
Grant W. Montgomery
Dennis O. Mook-Kanamori
Josyf C. Mychaleckyj
Girish N. Nadkarni
Mike A. Nalls
Matthias Nauck
Kjell Nikus
Boting Ning
Ilja M. Nolte
Raymond Noordam
Isleifur Olafsson
Albertine J. Oldehinkel
Marju Orho-Melander
Willem H. Ouwehand
Sandosh Padmanabhan
Nicholette D. Palmer
Runolfur Palsson
Brenda W. J. H. Penninx
Thomas Perls
Markus Perola
Mario Pirastu
Nicola Pirastu
Giorgio Pistis
Anna I. Podgornaia
Ozren Polasek
Belen Ponte
David J. Porteous
Tanja Poulain
Peter P. Pramstaller
Michael H. Preuss
Bram P. Prins
Michael A. Province
Ton J. Rabelink
Laura M. Raffield
Olli T. Raitakari
Dermot F. Reilly
Rainer Rettig
Myriam Rheinberger
Kenneth M. Rice
Paul M. Ridker
Fernando Rivadeneira
Federica Rizzi
David J. Roberts
Antonietta Robino
Peter Rossing
Igor Rudan
Rico Rueedi
Daniela Ruggiero
Kathleen A. Ryan
Yasaman Saba
Charumathi Sabanayagam
Veikko Salomaa
Erika Salvi
Kai-Uwe Saum
Helena Schmidt
Reinhold Schmidt
Ben Schottker
Christina-Alexandra Schulz
Nicole Schupf
Christian M. Shaffer
Yuan Shi
Albert V. Smith
Blair H. Smith
Nicole Soranzo
Cassandra N. Spracklen
Konstantin Strauch
Heather M. Stringham
Michael Stumvoll
Per O. Svensson
Silke Szymczak
E-Shyong Tai
Salman M. Tajuddin
Nicholas Y. Q. Tan
Kent D. Taylor
Andrej Teren
Yih-Chung Tham
Joachim Thiery
Chris H. L. Thio
Hauke Thomsen
Gudmar Thorleifsson
Daniela Toniolo
Anke Tonjes
Johanne Tremblay
Ioanna Tzoulaki
Andre G. Uitterlinden
Simona Vaccargiu
Rob M. Van Dam
Pim Van der Harst
Cornelia M. Van Duijn
Digna R. Velez Edward
Niek Verweij
Suzanne Vogelezang
Uwe Volker
Peter Vollenweider
Gerard Waeber
Melanie Waldenberger
Lars Wallentin
Ya Xing Wang
Chaolong Wang
Dawn M. Waterworth
Wen Bin Wei
Harvey White
John B. Whitfield
Sarah H. Wild
James F. Wilson
Mary K. Wojczynski
Charlene Wong
Tien-Yin Wong
Liang Xu
Qiong Yang
Masayuki Yasuda
Laura M. Yerges-Armstrong
Weihua Zhang
Alan B. Zonderman
Jerome I. Rotter
Murielle Bochud
Bruce M. Psaty
Veronique Vitart
James G. Wilson
Abbas Dehghan
Afshin Parsa
Daniel I. Chasman
Kevin Ho
Andrew P. Morris
Olivier Devuyst
Shreeram Akilesh
Sarah A. Pendergrass
Xueling Sim
Carsten A. Boger
Yukinori Okada
Todd L. Edwards
Harold Snieder
Kari Stefansson
Adriana M. Hung
Iris M. Heid
Markus Scholz
Alexander Teumer
Anna Kottgen
Cristian Pattaro
Informatik, Informationswissenschaft, allgemeine Werke
Referiert
Hasso-Plattner-Institut für Digital Engineering GmbH
Import
Green Open-Access
52480
2018
2018
eng
33
2
861
article
IOP Publ. Ltd.
Bristol
1
2018-07-12
2018-07-12
--
A Very High Energy gamma-Ray Survey toward the Cygnus Region of the Galaxy
We present results from deep observations toward the Cygnus region using 300 hr of very high energy (VHE)gamma-ray data taken with the VERITAS Cerenkov telescope array and over 7 yr of high-energy.-ray data taken with the Fermi satellite at an energy above 1 GeV. As the brightest region of diffuse gamma-ray emission in the northern sky, the Cygnus region provides a promising area to probe the origins of cosmic rays. We report the identification of a potential Fermi-LAT counterpart to VER J2031+415 (TeV J2032+4130) and resolve the extended VHE source VER J2019+368 into two source candidates (VER J2018+367* and VER J2020+368*) and characterize their energy spectra. The Fermi-LAT morphology of 3FGL J2021.0+4031e (the Gamma Cygni supernova remnant) was examined, and a region of enhanced emission coincident with VER J2019+407 was identified and jointly fit with the VERITAS data. By modeling 3FGL J2015.6+3709 as two sources, one located at the location of the pulsar wind nebula CTB 87 and one at the quasar QSO J2015+371, a continuous spectrum from 1 GeV to 10 TeV was extracted for VER J2016+371 (CTB 87). An additional 71 locations coincident with Fermi-LAT sources and other potential objects of interest were tested for VHE gamma-ray emission, with no emission detected and upper limits on the differential flux placed at an average of 2.3% of the Crab Nebula flux. We interpret these observations in a multiwavelength context and present the most detailed gamma-ray view of the region to date.
The astrophysical journal : an international review of spectroscopy and astronomical physics
10.3847/1538-4357/aac4a2
0004-637X
1538-4357
wos:2018
134
WOS:000438684300014
Bird, R (reprint author), Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90095 USA., ralphbird@astro.ucla.edu; maria.krause@desy.de; apopkow@ucla.edu
U.S. Department of Energy Office of ScienceUnited States Department of Energy (DOE); U.S. National Science FoundationNational Science Foundation (NSF); Smithsonian InstitutionSmithsonian Institution; NSERC in CanadaNatural Sciences and Engineering Research Council of Canada; ESA Member StatesEuropean Space Agency; NASANational Aeronautics & Space Administration (NASA); Natural Sciences and Engineering Research CouncilNatural Sciences and Engineering Research Council of Canada
2021-11-01T11:44:04+00:00
sword
importub
filename=package.tar
776c3060d868a59b72b68e62c2735729
A. U. Abeysekara
A. Archer
Taylor Aune
Wystan Benbow
Ralph Bird
Robert Brose
M. Buchovecky
V. Bugaev
Wei Cui
M. K. Daniel
A. Falcone
Qi Feng
John P. Finley
H. Fleischhack
A. Flinders
L. Fortson
Amy Furniss
Eric V. Gotthelf
J. Grube
David Hanna
O. Hervet
J. Holder
K. Huang
G. Hughes
T. B. Humensky
M. Huetten
Caitlin A. Johnson
Philip Kaaret
P. Kar
N. Kelley-Hoskins
M. Kertzman
David Kieda
Maria Krause
S. Kumar
M. J. Lang
T. T. Y. Lin
Gernot Maier
S. McArthur
P. Moriarty
Reshmi Mukherjee
R. A. Ong
Adam Nepomuk Otte
Dirk Pandel
Nahee Park
A. Petrashyk
Martin Pohl
Alexis Popkow
Elisa Pueschel
J. Quinn
K. Ragan
P. T. Reynolds
Gregory T. Richards
E. Roache
J. Rousselle
C. Rulten
I. Sadeh
M. Santander
G. H. Sembroski
Karlen Shahinyan
J. Tyler
V. V. Vassiliev
S. P. Wakely
J. E. Ward
A. Weinstein
R. M. Wells
P. Wilcox
Alina Wilhelm
David A. Williams
B. Zitzer
eng
uncontrolled
acceleration of particles
eng
uncontrolled
cosmic rays
eng
uncontrolled
gamma rays: general
eng
uncontrolled
ISM: supernova remnants
Physik
Institut für Physik und Astronomie
Referiert
Import
Green Open-Access
49166
2019
2019
eng
1123
1134
12
6
1861
article
Elsevier
Amsterdam
1
2019-03-20
2019-03-20
--
Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes
Influenza A virus is a pathogen responsible for severe seasonal epidemics threatening human and animal populations every year. One of the ten major proteins encoded by the viral genome, the matrix protein M1, is abundantly produced in infected cells and plays a structural role in determining the morphology of the virus. During assembly of new viral particles, M1 is recruited to the host cell membrane where it associates with lipids and other viral proteins. The structure of M1 is only partially known. In particular, structural details of M1 interactions with the cellular plasma membrane as well as M1 protein interactions and multimerization have not been clarified, yet. In this work, we employed a set of complementary experimental and theoretical tools to tackle these issues. Using raster image correlation, surface plasmon resonance and circular dichroism spectroscopies, we quantified membrane association and oligomerization of full-length M1 and of different genetically engineered M1 constructs (i.e., N- and C-terminally truncated constructs and a mutant of the polybasic region, residues 95-105). Furthermore, we report novel information on structural changes in M1 occurring upon binding to membranes. Our experimental results are corroborated by an all-atom model of the full-length M1 protein bound to a negatively charged lipid bilayer.
Biochimica et biophysica acta : Biomembranes
10.1016/j.bbamem.2019.03.013
30902626
0005-2736
1879-2642
wos:2019
WOS:000470339300010
Herrmann, A (reprint author), Humboldt Univ, Inst Biol, IRI Life Sci, Invalidenstr 42, D-10115 Berlin, Germany.; Chiantia, S (reprint author), Univ Potsdam, Inst Biochem & Biol, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany., andreas.herrmann@cms.hu-berlin.de; chiantia@uni-potsdam.de
German Research Foundation (DFG)German Research Foundation (DFG) [CH 1238/3, KE 1478/4, SFB 740, HE 3763/15]; Natural Science Foundation of ChinaNational Natural Science Foundation of China [91430112]; Alexander-von-Humboldt Foundation in GermanyAlexander von Humboldt Foundation
2021-01-28T13:45:23+00:00
sword
importub
filename=package.tar
66bf51edeb7ebbf623c3ffe4b0b9badc
Herrmann, A.
Chianta, Salvatore
false
true
C. T. Höfer
S. Di Lella
Ismail Dahmani
N. Jungnick
N. Bordag
Sara Bobone
Q. Huang
S. Keller
A. Herrmann
Salvatore Chiantia
eng
uncontrolled
Virus assembly
eng
uncontrolled
Protein-lipid interaction
eng
uncontrolled
Fluorescence microscopy
eng
uncontrolled
SPR
eng
uncontrolled
CD spectroscopy
eng
uncontrolled
Influenza A virus
Biowissenschaften; Biologie
Institut für Biochemie und Biologie
Referiert
Import
38291
2014
2014
eng
1305
1321
17
4
18
article
Copernicus
Göttingen
1
--
--
--
Comparing impacts of climate change on streamflow in four large African river basins
This study aims to compare impacts of climate change on streamflow in four large representative African river basins: the Niger, the Upper Blue Nile, the Oubangui and the Limpopo. We set up the eco-hydrological model SWIM (Soil and Water Integrated Model) for all four basins individually. The validation of the models for four basins shows results from adequate to very good, depending on the quality and availability of input and calibration data.
For the climate impact assessment, we drive the model with outputs of five bias corrected Earth system models of Coupled Model Intercomparison Project Phase 5 (CMIP5) for the representative concentration pathways (RCPs) 2.6 and 8.5. This climate input is put into the context of climate trends of the whole African continent and compared to a CMIP5 ensemble of 19 models in order to test their representativeness. Subsequently, we compare the trends in mean discharges, seasonality and hydrological extremes in the 21st century. The uncertainty of results for all basins is high. Still, climate change impact is clearly visible for mean discharges but also for extremes in high and low flows. The uncertainty of the projections is the lowest in the Upper Blue Nile, where an increase in streamflow is most likely. In the Niger and the Limpopo basins, the magnitude of trends in both directions is high and has a wide range of uncertainty. In the Oubangui, impacts are the least significant. Our results confirm partly the findings of previous continental impact analyses for Africa. However, contradictory to these studies we find a tendency for increased streamflows in three of the four basins (not for the Oubangui). Guided by these results, we argue for attention to the possible risks of increasing high flows in the face of the dominant water scarcity in Africa. In conclusion, the study shows that impact intercomparisons have added value to the adaptation discussion and may be used for setting up adaptation plans in the context of a holistic approach.
Hydrology and earth system sciences : HESS
10.5194/hess-18-1305-2014
1027-5606
1607-7938
wos:2014
WOS:000335375300005
Aich, V (reprint author), Potsdam Inst Climate Impact Res, Potsdam, Germany., aich@pik-potsdam.de
IMPACT2c project
Valentin Aich
Stefan Liersch
T. Vetter
S. Huang
J. Tecklenburg
P. Hoffmann
H. Koch
S. Fournet
Valentina Krysanova
N. Mueller
Fred Fokko Hattermann
Institut für Geowissenschaften
Referiert
Open Access
Institut für Erd- und Umweltwissenschaften
39159
2015
2015
eng
1155
1168
14
4
24
article
Oxford Univ. Press
Oxford
Early Genetics Lifecourse, Genetic Invest ANthropometric, Early Growth Genetics EGG
1
--
--
--
A novel common variant in DCST2 is associated with length in early life and height in adulthood
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
Human molecular genetics
10.1093/hmg/ddu510
25281659
0964-6906
1460-2083
wos:2015
WOS:000350138300021
Jaddoe, VWV (reprint author), Sophias Childrens Hosp, Erasmus Med Ctr, Dept Epidemiol, Generat Study Grp R, Postbus 2060, NL-3000 CB Rotterdam, Netherlands., v.jaddoe@erasmusmc.nl
Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust)
[085541/Z/08/Z]; Danish Council for Independent Research Medical
Sciences (FSS) The Alfred Benzon Foundation; Oak Foundation fellowship;
Wellcome Trust [090532]; European Research Council [SZ-245
50371-GLUCOSEGENES-FP7-IDEAS-ERC]; Netherlands Organization for Health
Research and Development [VIDI 016.136.367, VIDI 016.136.361]
Ralf J. P. van der Valk
Eskil Kreiner-Moller
Marjolein N. Kooijman
Monica Guxens
Evangelia Stergiakouli
Annika Saaf
Jonathan P. Bradfield
Frank Geller
M. Geoffrey Hayes
Diana L. Cousminer
Antje Koerner
Elisabeth Thiering
John A. Curtin
Ronny Myhre
Ville Huikari
Raimo Joro
Marjan Kerkhof
Nicole M. Warrington
Niina Pitkanen
Ioanna Ntalla
Momoko Horikoshi
Riitta Veijola
Rachel M. Freathy
Yik-Ying Teo
Sheila J. Barton
David M. Evans
John P. Kemp
Beate St Pourcain
Susan M. Ring
George Davey Smith
Anna Bergstrom
Inger Kull
Hakon Hakonarson
Frank D. Mentch
Hans Bisgaard
Bo Lund Krogsgaard Chawes
Jakob Stokholm
Johannes Waage
Patrick Eriksen
Astrid Sevelsted
Mads Melbye
Cornelia M. van Duijn
Carolina Medina-Gomez
Albert Hofman
Johan C. de Jongste
H. Rob Taal
Andre G. Uitterlinden
Loren L. Armstrong
Johan Eriksson
Aarno Palotie
Mariona Bustamante
Xavier Estivill
Juan R. Gonzalez
Sabrina Llop
Wieland Kiess
Anubha Mahajan
Claudia Flexeder
Carla M. T. Tiesler
Clare S. Murray
Angela Simpson
Per Magnus
Verena Sengpiel
Anna-Liisa Hartikainen
Sirkka Keinanen-Kiukaanniemi
Alexandra Lewin
Alexessander Da Silva Couto Alves
Alexandra I. F. Blakemore
Jessica L. Buxton
Marika Kaakinen
Alina Rodriguez
Sylvain Sebert
Marja Vaarasmaki
Timo Lakka
Virpi Lindi
Ulrike Gehring
Dirkje S. Postma
Wei Ang
John P. Newnham
Leo-Pekka Lyytikainen
Katja Pahkala
Olli T. Raitakari
Kalliope Panoutsopoulou
Eleftheria Zeggini
Dorret I. Boomsma
Maria Groen-Blokhuis
Jorma Ilonen
Lude Franke
Joel N. Hirschhorn
Tune H. Pers
Liming Liang
Jinyan Huang
Berthold Hocher
Mikael Knip
Seang-Mei Saw
John W. Holloway
Erik Melen
Struan F. A. Grant
Bjarke Feenstra
William L. Lowe
Elisabeth Widen
Elena Sergeyev
Harald Grallert
Adnan Custovic
Bo Jacobsson
Marjo-Riitta Jarvelin
Mustafa Atalay
Gerard H. Koppelman
Craig E. Pennell
Harri Niinikoski
George V. Dedoussis
Mark I. Mccarthy
Timothy M. Frayling
Jordi Sunyer
Nicholas J. Timpson
Fernando Rivadeneira
Klaus Bonnelykke
Vincent W. V. Jaddoe
Institut für Ernährungswissenschaft
Referiert
16475
2003
2003
eng
article
1
--
--
--
Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of ES cell-derived embryoid bodies and multicellular tumor spheroids by plant ingredients use
allegro:1991-2014
10099233
Laboratory investigation. - 83 (2003), S. 87 - 98
Maria Wartenberg
Paula Budde
M. de Mareés
S. Y. Tsang
Y. Huang
Zhen-Yu Chen
Jürgen Hescheler
Heinrich Sauer
Institut für Biochemie und Biologie
Referiert