35934
2012
2012
eng
532
+
9
5
44
article
Nature Publ. Group
New York
Cohorts Heart Aging Res Genetic Ep, Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti
1
--
--
--
Common variants at 12q15 and 12q24 are associated with infant head circumference
To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
Nature genetics
10.1038/ng.2238
1061-4036
wos:2011-2013
WOS:000303416300013
Smith, GD (reprint author), Univ Bristol, MRC, Ctr Causal Anal Translat Epidemiol, Sch Social & Community Med, Bristol, Avon, England., Julia.Mackay@bristol.ac.uk; heinrich@helmholtz-muenchen.de; m.jarvelin@imperial.ac.uk; v.jaddoe@erasmusmc.nl; heinrich@helmholtz-muenchen.de; v.jaddoe@erasmusmc.nl; m.jarvelin@imperial.ac.uk; heinrich@helmholtz-muenchen.de; v.jaddoe@erasmusmc.nl; m.jarvelin@imperial.ac.uk
Academy of Finland [104781, 120315, 129269, 1114194, 134839, 129287];
Biocentrum Helsinki; Biocenter, University of Oulu, Finland; British
Heart Foundation; Canadian Institutes of Health Research [MOP 82893];
The Children's Hospital of Philadelphia; Cotswold Foundation; Darlington
Trust; Dutch Asthma Foundation; Dutch Ministry of the Environment;
Erasmus Medical Center Rotterdam; Erasmus University Rotterdam; European
Community [HEALTH-F4-2007-201413]; Exeter National Health Service (NHS)
Research and Development; Fundacio La Marato de TV3 (Televisio de
Catalunya); Helmholtz Zentrum Muenchen; German Research Center for
Environment and Health; Institute of Epidemiology I; Neuherberg;
Instituto de Salud Carlos III [FIS PI081151, PS09/00432]; Institut fur
Umweltmedizinische Forschung (IUF) Dusseldorf; Marien-Hospital Wesel; UK
MRC [G0500539, G0600331, G0600705]; Municipal Health Service Rotterdam;
National Health and Medical Research Council of Australia [403981,
003209]; National Public Health Institute, Helsinki, Finland;
Netherlands Organisation for Scientific Research (NWO); Netherlands
Organisation for Health Research and Development (ZonMw) [SPI
56-464-14192, 904-61-090, 904-61-193, 912-03-031, 480-04-004,
400-05-717]; US NHLBI [5R01HL087679-02, 1RL1MH083268-01]; US NIH
[1R01HD056465-01A1]; Peninsula NIHR Clinical Research Facility; RAINE
Medical Research Foundation; Rotterdam Homecare Foundation; South West
NHS Research and Development; Stichting Astmabestrijding; Stichting
Trombosedienst & Artsenlaboratorium Rijnmond (STAR) Rotterdam; Technical
University Munich; Telethon Institute for Child Health Research;
UFZ-Centre for Environmental Research Leipzig-Halle; University Hospital
Oulu, Finland; University of Bristol; University of Leipzig; Wellcome
Trust [GR069224, 085541/Z/08/Z, WT083431MA, WT088431MA]; Western
Australian DNA Bank; Western Australian Genetic Epidemiology Resource;
ZonMW [21000074]; Dutch Kidney Foundation [C08.2251]; MRC UK [G0500539,
PS0476]; MRC [MRC G0800582]; Netherlands Organisation for Health
Research (ZonMw) [90700303, 916.10159]
H. Rob Taal
Beate St Pourcain
Elisabeth Thiering
Shikta Das
Dennis O. Mook-Kanamori
Nicole M. Warrington
Marika Kaakinen
Eskil Kreiner-Moller
Jonathan P. Bradfield
Rachel M. Freathy
Frank Geller
Monica Guxens
Diana L. Cousminer
Marjan Kerkhof
Nicholas J. Timpson
M. Arfan Ikram
Lawrence J. Beilin
Klaus Bonnelykke
Jessica L. Buxton
Pimphen Charoen
Bo Lund Krogsgaard Chawes
Johan Eriksson
David M. Evans
Albert Hofman
John P. Kemp
Cecilia E. Kim
Norman Klopp
Jari Lahti
Stephen J. Lye
George McMahon
Frank D. Mentch
Martina Mueller-Nurasyid
Paul F. O'Reilly
Inga Prokopenko
Fernando Rivadeneira
Eric A. P. Steegers
Jordi Sunyer
Carla Tiesler
Hanieh Yaghootkar
Monique M. B. Breteler
Stephanie Debette
Myriam Fornage
Vilmundur Gudnason
Lenore J. Launer
Aad van der Lugt
Thomas H. Mosley
Sudha Seshadri
Albert V. Smith
Meike W. Vernooij
Alexandra I. F. Blakemore
Rosetta M. Chiavacci
Bjarke Feenstra
Julio Fernandez-Banet
Struan F. A. Grant
Anna-Liisa Hartikainen
Albert J. van der Heijden
Carmen Iniguez
Mark Lathrop
Wendy L. McArdle
Anne Molgaard
John P. Newnham
Lyle J. Palmer
Aarno Palotie
Annneli Pouta
Susan M. Ring
Ulla Sovio
Marie Standl
Andre G. Uitterlinden
H-Erich Wichmann
Nadja Hawwa Vissing
Charles DeCarli
Cornelia M. van Duijn
Mark I. McCarthy
Gerard H. Koppelman
Xavier Estivill
Andrew T. Hattersley
Mads Melbye
Hans Bisgaard
Craig E. Pennell
Elisabeth Widen
Hakon Hakonarson
George Davey Smith
Joachim Heinrich
Marjo-Riitta Jarvelin
Vincent W. V. Jaddoe
Linda S. Adair
Wei Ang
Mustafa Atalay
Toos van Beijsterveldt
Nienke Bergen
Kelly Benke
Diane J. Berry
Jonathan P. Bradfield
Pimphen Charoen
Lachlan Coin
Diana L. Cousminer
Shikta Das
Oliver S. P. Davis
Paul Elliott
David M. Evans
Bjarke Feenstra
Claudia Flexeder
Tim Frayling
Rachel M. Freathy
Romy Gaillard
Frank Geller
Maria Groen-Blokhuis
Liang-Kee Goh
Monica Guxens
Claire M. A. Haworth
Dexter Hadley
Johannes Hebebrand
Anke Hinney
Joel N. Hirschhorn
John W. Holloway
Claus Holst
Jouke Jan Hottenga
Momoko Horikoshi
Ville Huikari
Elina Hypponen
Carmen Iniguez
Marika Kaakinen
Tuomas O. Kilpelainen
Mirna Kirin
Matthew Kowgier
Hanna-Maaria Lakka
Leslie A. Lange
Debbie A. Lawlor
Terho Lehtimaki
Alex Lewin
Cecilia Lindgren
Virpi Lindi
Reedik Maggi
Julie Marsh
Christel Middeldorp
Iona Millwood
Dennis O. Mook-Kanamori
Jeffrey C. Murray
Michel Nivard
Ellen Aagaard Nohr
Ioanna Ntalla
Emily Oken
Paul F. O'Reilly
Lyle J. Palmer
Kalliope Panoutsopoulou
Jennifer Pararajasingham
Inga Prokopenko
Alina Rodriguez
Rany M. Salem
Sylvain Sebert
Niina Siitonen
Ulla Sovio
Beate St Pourcain
David P. Strachan
Jordi Sunyer
H. Rob Taal
Yik-Ying Teo
Elisabeth Thiering
Carla Tiesler
Andre G. Uitterlinden
Beatriz Valcarcel
Nicole M. Warrington
Scott White
Gonneke Willemsen
Hanieh Yaghootkar
Eleftheria Zeggini
Dorret I. Boomsma
Cyrus Cooper
Xavier Estivill
Matthew Gillman
Struan F. A. Grant
Hakon Hakonarson
Andrew T. Hattersley
Joachim Heinrich
Berthold Hocher
Vincent W. V. Jaddoe
Marjo-Riitta Jarvelin
Timo A. Lakka
Mark I. McCarthy
Mads Melbye
Karen L. Mohlke
George V. Dedoussis
Ken K. Ong
Ewan R. Pearson
Craig E. Pennell
Thomas S. Price
Chris Power
Olli T. Raitakari
Seang-Mei Saw
Andre Scherag
Olli Simell
Thorkild I. A. Sorensen
Nicholas J. Timpson
Elisabeth Widen
James F. Wilson
Wei Ang
Toos van Beijsterveldt
Nienke Bergen
Kelly Benke
Diane J. Berry
Jonathan P. Bradfield
Pimphen Charoen
Lachlan Coin
Diana L. Cousminer
Shikta Das
Paul Elliott
David M. Evans
Tim Frayling
Rachel M. Freathy
Romy Gaillard
Maria Groen-Blokhuis
Monica Guxens
Dexter Hadley
Jouke Jan Hottenga
Ville Huikari
Elina Hypponen
Marika Kaakinen
Matthew Kowgier
Debbie A. Lawlor
Alex Lewin
Cecilia Lindgren
Julie Marsh
Christel Middeldorp
Iona Millwood
Dennis O. Mook-Kanamori
Michel Nivard
Paul F. O'Reilly
Lyle J. Palmer
Inga Prokopenko
Alina Rodriguez
Sylvain Sebert
Ulla Sovio
Beate St Pourcain
Marie Standl
David P. Strachan
Jordi Sunyer
H. Rob Taal
Elisabeth Thiering
Carla Tiesler
Andre G. Uitterlinden
Beatriz Valcarcel
Nicole M. Warrington
Scott White
Gonneke Willemsen
Hanieh Yaghootkar
Dorret I. Boomsma
Xavier Estivill
Struan F. A. Grant
Hakon Hakonarson
Andrew T. Hattersley
Joachim Heinrich
Vincent W. V. Jaddoe
Marjo-Riitta Jarvelin
Mark I. McCarthy
Craig E. Pennell
Chris Power
Nicholas J. Timpson
Elisabeth Widen
M. Arfan Ikram
Myriam Fornage
Albert V. Smith
Sudha Seshadri
Reinhold Schmidt
Stephanie Debette
Henri A. Vrooman
Sigurdur Sigurdsson
Stefan Ropele
Laura H. Coker
W. T. Longstreth
Wiro J. Niessen
Anita L. DeStefano
Alexa Beiser
Alex P. Zijdenbos
Maksim Struchalin
Clifford R. Jack
Mike A. Nalls
Rhoda Au
Albert Hofman
Haukur Gudnason
Aad van der Lugt
Tamara B. Harris
William M. Meeks
Meike W. Vernooij
Mark A. van Buchem
Diane Catellier
Vilmundur Gudnason
B. Gwen Windham
Philip A. Wolf
Cornelia M. van Duijn
Thomas H. Mosley
Helena Schmidt
Lenore J. Launer
Monique M. B. Breteler
Charles DeCarli
Institut für Biochemie und Biologie
Referiert
35420
2013
2013
eng
76
U115
10
1
45
article
Nature Publ. Group
New York
MAGIC, Early Growth Genetics EGG
1
--
--
--
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Nature genetics
10.1038/ng.2477
1061-4036
wos:2011-2013
WOS:000312838800016
McCarthy, MI (reprint author), Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England., mark.mccarthy@drl.ox.ac.uk; grants@chop.edu; v.jaddoe@erasmusmc.nl; m.jarvelin@imperial.ac.uk; n.j.timpson@bristol.ac.uk; ingap@well.ox.ac.uk; rachel.freathy@pms.ac.uk
Academy of Finland [126925, 121584, 124282, 129378, 117787, 41071,
209072, 129255, 104781, 120315, 129269, 1114194, 206374, 251360,
139900/24300796]; Biocentrum Helsinki; Arthritis Research UK; Augustinus
Foundation; Biobanking and Biomolecular Resources Research
Infrastructure (BBMRI-NL); Biomedical Research Council, Singapore [BMRC
06/1/21/19/466]; BIF: Boehringer Ingelheim Fonds; British Heart
Foundation; C.G. Sundell Foundation; Canadian Institutes of Health
Research [MOP-82893]; Cancer Research UK; Chief Scientist Office of the
Scottish Government; Children's Hospital of Philadelphia (Institute
Development Award); Conselleria de Sanitat Generalitat Valenciana;
Copenhagen Graduate School of Health Sciences; Cotswold Foundation
(Research Development Award); Curtin University and Women and Infants
Research Foundation; Danish Health Insurance Societies (Health Fund);
Danish Medical Research Council; Danish National Research Foundation;
Danish Pediatric Asthma Centre; Danish Pharmacists' Fund; Danish
Strategic Research Council; Darlington Trust; Department of Health and
Social Services in Northern Ireland; Deutsche Forschungsgemeinschaft
(DFG); Diabetes Hilfs-und Forschungsfonds Deutschland (DHFD); Diabetes
UK [RD08/0003704, RD08/0003692]; Dunhill Medical Trust; Dutch Asthma
Foundation [3.4.01.26, 3.2.06.022, 3.4.09.081, 3.2.10.085CO]; Dutch
Ministry of the Environment (EFRE); Europaische Fonds fur Regionale
Entwicklung (LIFE Child Obesity); Egmont Foundation; Else
Kroner-Fresenius Foundation; Emil Aaltonen Foundation; ENGAGE project
[HEALTH-F4-2007-201413]; Erasmus Medical Center; Erasmus University,
Rotterdam; European Commission [QLG1-CT-2000-01643, 018996,
LSHG-CT-2006-018947, FOOD-CT-2005-007034]; European Research Council
(ERC Advanced) [230374]; European Science Foundation (ESF)
[EU/QLRT-2001-01254]; Exeter NHS Research and Development; Faculty of
Biology and Medicine of Lausanne; Finnish Foundation of Cardiovascular
Research; Finnish Cultural Foundation; Finnish Innovation Fund Sitra;
Finnish Ministry of Education and Culture; Finnish Ministry of Social
Affairs and Health; Finnish Social Insurance Institution; Foundation for
Paediatric Research; Fundacio La Marato de TV3; Fundacion Roger Torne;
Generalitat de Catalunya-Interminesterial Council for Research and
Technological Innovation (CIRIT) [(1999SGR) 00241]; German Diabetes
Association; German Bundesministerium fuer Forschung und Technology [01
AK 803 A-H, 01 IG 07015 G]; German Research Foundation for the Clinical
Research Group Atherobesity [KO3512/1]; GlaxoSmithKline; Hagedorn
Research Institute; Instituto de Salud Carlos III [CB06/02/0041, FIS
PI041436, PI081151, PI041705, PS09/00432, FISFEDER 03/1615, 04/1509,
04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647];
Interdisciplinary Centre for Clinical Research at the University of
Leipzig [B27]; Integrated Research and Treatment Centre (IFB) Adiposity
Diseases; Jackstadt-Foundation; Juho Vainio Foundation; Juvenile
Diabetes Research Foundation International (JDRF); Kuopio, Tampere and
Turku University Hospital Medical Funds [5031343, 9M048]; Lundbeck
Foundation; Lundbeck Foundation Centre of Applied Medical Genomics for
Personalized Disease Prediction, Prevention and Care (LuCAMP); March of
Dimes Birth Defects Foundation [6-FY09-507]; MRC, UK [74882, G0000934,
G0601653, G0500539, G0600705, G0601261, G0600331, PrevMetSyn/SALVE
PS0476, MC-A760-5QX00]; Munich Center of Health Sciences (MC Health);
National Health and Medical Research Council of Australia [403981,
003209]; US National Human Genome Research Institute; US National
Institute of Allergy and Infectious Diseases; US National Institute of
Child Health and Human Development; US National Institute of Diabetes
and Digestive and Kidney Diseases (NIDDK); US National Institutes of
Health [U01DK062418, U01HG004423, U01HG004446, U01HG004438, R01DK075787,
1R01HD056465-01A, R01D0042157-01A, DK078150, TW05596, HL085144,
HD054501, RR20649, ES10126, DK56350]; Netherlands Bioinformatics Centre
(NBIC) BioAssist [RK/2008.024]; National Heart, Lung, and Blood
Institute (NHLBI) [5R01HL087679-02]; National Heart, Lung, and Blood
Institute (NHLBI) through the STAMPEED program [1RL1MH083268-01]; NIH
Genetic Association Information Network (GAIN); NIH/National Institute
of Mental Health (NIMH) [5R01MH63706: 02, MH081802]; Rutgers University
Cell and DNA Repository cooperative agreement [NIMH U24 MH068457-06];
Novo Nordisk Foundation Center for Basic Metabolic Research; Center for
Medical Systems Biology (CMSB; NWO Genomics); Netherlands Organization
for Scientific Research (NWO: Social Sciences (MaGW); Netherlands
Organization for Health Research and Development (ZonMw)
[Middelgroot-911-09-032, Spinozapremie 56-464-14192, 904-61-090,
904-61-193, 480-04-004, 400-05-717, Addiction-31160008, 985-10-002,
40-005698- 9032, 912-03-031]; Paavo Nurmi Foundation; Peninsula NIHR
Clinical Research Facility; Pharmacy Foundation of 1991; PhD School of
Molecular Metabolism University of Southern Denmark; Raine Medical
Research Foundation; Royal Society; Sigrid Juselius Foundation; South
West NHS Research and Development; Spanish Ministry of Science and
Innovation [SAF2008-00357]; Turku University Hospital; Swiss National
Science Foundation [33CSCO-122661]; Tampere Tuberculosis Foundation;
Telethon Institute for Child Health Research; Turku University
Foundation; US Centers for Disease Control and Prevention; University
Hospital Oulu, Biocenter, the University of Oulu [75617]; University of
Bristol; University of Potsdam; University of Southampton; University of
Western Australia (UWA); VU Institute for Health and Care Research
(EMGO+); Neuroscience Campus Amsterdam (NCA); Wellcome Trust [GR069224,
WT088806, 068545/Z/02, 076467, 085301, 090532, 083270, 083948,
085541/Z/08/Z, WT089549, WT083431MA]; Yrjo Jahnsson Foundation; Academy
of Finland (Center of Excellence in Complex Disease Genetics); Academy
of Finland (SALVE)
Momoko Horikoshi
Hanieh Yaghootkar
Dennis O. Mook-Kanamori
Ulla Sovio
H. Rob Taal
Branwen J. Hennig
Jonathan P. Bradfield
Beate St Pourcain
David M. Evans
Pimphen Charoen
Marika Kaakinen
Diana L. Cousminer
Terho Lehtimaki
Eskil Kreiner-Moller
Nicole M. Warrington
Mariona Bustamante
Bjarke Feenstra
Diane J. Berry
Elisabeth Thiering
Thiemo Pfab
Sheila J. Barton
Beverley M. Shields
Marjan Kerkhof
Elisabeth M. van Leeuwen
Anthony J. Fulford
Zoltan Kutalik
Jing Hua Zhao
Marcel den Hoed
Anubha Mahajan
Virpi Lindi
Liang-Kee Goh
Jouke-Jan Hottenga
Ying Wu
Olli T. Raitakari
Marie N. Harder
Aline Meirhaeghe
Ioanna Ntalla
Rany M. Salem
Karen A. Jameson
Kaixin Zhou
Dorota M. Monies
Vasiliki Lagou
Mirna Kirin
Jani Heikkinen
Linda S. Adair
Fowzan S. Alkuraya
Ali Al-Odaib
Philippe Amouyel
Ehm Astrid Andersson
Amanda J. Bennett
Alexandra I. F. Blakemore
Jessica L. Buxton
Jean Dallongeville
Shikta Das
Eco J. C. de Geus
Xavier Estivill
Claudia Flexeder
Philippe Froguel
Frank Geller
Keith M. Godfrey
Frederic Gottrand
Christopher J. Groves
Torben Hansen
Joel N. Hirschhorn
Albert Hofman
Mads V. Hollegaard
David M. Hougaard
Elina Hyppoenen
Hazel M. Inskip
Aaron Isaacs
Torben Jorgensen
Christina Kanaka-Gantenbein
John P. Kemp
Wieland Kiess
Tuomas O. Kilpelainen
Norman Klopp
Bridget A. Knight
Christopher W. Kuzawa
George McMahon
John P. Newnham
Harri Niinikoski
Ben A. Oostra
Louise Pedersen
Dirkje S. Postma
Susan M. Ring
Fernando Rivadeneira
Neil R. Robertson
Sylvain Sebert
Olli Simell
Torsten Slowinski
Carla M. T. Tiesler
Anke Toenjes
Allan Vaag
Jorma S. Viikari
Jacqueline M. Vink
Nadja Hawwa Vissing
Nicholas J. Wareham
Gonneke Willemsen
Daniel R. Witte
Haitao Zhang
Jianhua Zhao
James F. Wilson
Michael Stumvoll
Andrew M. Prentice
Brian F. Meyer
Ewan R. Pearson
Colin A. G. Boreham
Cyrus Cooper
Matthew W. Gillman
George V. Dedoussis
Luis A. Moreno
Oluf Pedersen
Maiju Saarinen
Karen L. Mohlke
Dorret I. Boomsma
Seang-Mei Saw
Timo A. Lakka
Antje Koerner
Ruth J. F. Loos
Ken K. Ong
Peter Vollenweider
Cornelia M. van Duijn
Gerard H. Koppelman
Andrew T. Hattersley
John W. Holloway
Berthold Hocher
Joachim Heinrich
Chris Power
Mads Melbye
Monica Guxens
Craig E. Pennell
Klaus Bonnelykke
Hans Bisgaard
Johan G. Eriksson
Elisabeth Widen
Hakon Hakonarson
Andre G. Uitterlinden
Anneli Pouta
Debbie A. Lawlor
George Davey Smith
Timothy M. Frayling
Mark I. McCarthy
Struan F. A. Grant
Vincent W. V. Jaddoe
Marjo-Riitta Jarvelin
Nicholas J. Timpson
Inga Prokopenko
Rachel M. Freathy
Institut für Ernährungswissenschaft
Referiert
39159
2015
2015
eng
1155
1168
14
4
24
article
Oxford Univ. Press
Oxford
Early Genetics Lifecourse, Genetic Invest ANthropometric, Early Growth Genetics EGG
1
--
--
--
A novel common variant in DCST2 is associated with length in early life and height in adulthood
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
Human molecular genetics
10.1093/hmg/ddu510
25281659
0964-6906
1460-2083
wos:2015
WOS:000350138300021
Jaddoe, VWV (reprint author), Sophias Childrens Hosp, Erasmus Med Ctr, Dept Epidemiol, Generat Study Grp R, Postbus 2060, NL-3000 CB Rotterdam, Netherlands., v.jaddoe@erasmusmc.nl
Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust)
[085541/Z/08/Z]; Danish Council for Independent Research Medical
Sciences (FSS) The Alfred Benzon Foundation; Oak Foundation fellowship;
Wellcome Trust [090532]; European Research Council [SZ-245
50371-GLUCOSEGENES-FP7-IDEAS-ERC]; Netherlands Organization for Health
Research and Development [VIDI 016.136.367, VIDI 016.136.361]
Ralf J. P. van der Valk
Eskil Kreiner-Moller
Marjolein N. Kooijman
Monica Guxens
Evangelia Stergiakouli
Annika Saaf
Jonathan P. Bradfield
Frank Geller
M. Geoffrey Hayes
Diana L. Cousminer
Antje Koerner
Elisabeth Thiering
John A. Curtin
Ronny Myhre
Ville Huikari
Raimo Joro
Marjan Kerkhof
Nicole M. Warrington
Niina Pitkanen
Ioanna Ntalla
Momoko Horikoshi
Riitta Veijola
Rachel M. Freathy
Yik-Ying Teo
Sheila J. Barton
David M. Evans
John P. Kemp
Beate St Pourcain
Susan M. Ring
George Davey Smith
Anna Bergstrom
Inger Kull
Hakon Hakonarson
Frank D. Mentch
Hans Bisgaard
Bo Lund Krogsgaard Chawes
Jakob Stokholm
Johannes Waage
Patrick Eriksen
Astrid Sevelsted
Mads Melbye
Cornelia M. van Duijn
Carolina Medina-Gomez
Albert Hofman
Johan C. de Jongste
H. Rob Taal
Andre G. Uitterlinden
Loren L. Armstrong
Johan Eriksson
Aarno Palotie
Mariona Bustamante
Xavier Estivill
Juan R. Gonzalez
Sabrina Llop
Wieland Kiess
Anubha Mahajan
Claudia Flexeder
Carla M. T. Tiesler
Clare S. Murray
Angela Simpson
Per Magnus
Verena Sengpiel
Anna-Liisa Hartikainen
Sirkka Keinanen-Kiukaanniemi
Alexandra Lewin
Alexessander Da Silva Couto Alves
Alexandra I. F. Blakemore
Jessica L. Buxton
Marika Kaakinen
Alina Rodriguez
Sylvain Sebert
Marja Vaarasmaki
Timo Lakka
Virpi Lindi
Ulrike Gehring
Dirkje S. Postma
Wei Ang
John P. Newnham
Leo-Pekka Lyytikainen
Katja Pahkala
Olli T. Raitakari
Kalliope Panoutsopoulou
Eleftheria Zeggini
Dorret I. Boomsma
Maria Groen-Blokhuis
Jorma Ilonen
Lude Franke
Joel N. Hirschhorn
Tune H. Pers
Liming Liang
Jinyan Huang
Berthold Hocher
Mikael Knip
Seang-Mei Saw
John W. Holloway
Erik Melen
Struan F. A. Grant
Bjarke Feenstra
William L. Lowe
Elisabeth Widen
Elena Sergeyev
Harald Grallert
Adnan Custovic
Bo Jacobsson
Marjo-Riitta Jarvelin
Mustafa Atalay
Gerard H. Koppelman
Craig E. Pennell
Harri Niinikoski
George V. Dedoussis
Mark I. Mccarthy
Timothy M. Frayling
Jordi Sunyer
Nicholas J. Timpson
Fernando Rivadeneira
Klaus Bonnelykke
Vincent W. V. Jaddoe
Institut für Ernährungswissenschaft
Referiert