41925
2018
2018
eng
12
473
postprint
1
2018-11-12
2018-11-12
--
Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level
Recent research suggests that the P3b may be closely related to the activation of the locus coeruleus-norepinephrine (LC-NE) system. To further study the potential association, we applied a novel technique, the non-invasive transcutaneous vagus nerve stimulation (tVNS), which is speculated to increase noradrenaline levels. Using a within-subject cross-over design, 20 healthy participants received continuous tVNS and sham stimulation on two consecutive days (stimulation counterbalanced across participants) while performing a visual oddball task. During stimulation, oval non-targets (standard), normal-head (easy) and rotated-head (difficult) targets, as well as novel stimuli (scenes) were presented. As an indirect marker of noradrenergic activation we also collected salivary alpha-amylase (sAA) before and after stimulation. Results showed larger P3b amplitudes for target, relative to standard stimuli, irrespective of stimulation condition. Exploratory post hoc analyses, however, revealed that, in comparison to standard stimuli, easy (but not difficult) targets produced larger P3b (but not P3a) amplitudes during active tVNS, compared to sham stimulation. For sAA levels, although main analyses did not show differential effects of stimulation, direct testing revealed that tVNS (but not sham stimulation) increased sAA levels after stimulation. Additionally, larger differences between tVNS and sham stimulation in P3b magnitudes for easy targets were associated with larger increase in sAA levels after tVNS, but not after sham stimulation. Despite preliminary evidence for a modulatory influence of tVNS on the P3b, which may be partly mediated by activation of the noradrenergic system, additional research in this field is clearly warranted. Future studies need to clarify whether tVNS also facilitates other processes, such as learning and memory, and whether tVNS can be used as therapeutic tool.
Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
A Pilot Study
urn:nbn:de:kobv:517-opus4-419259
online registration
202
Frontiers in Human Neuroscience 12 (2018) Art. 202 DOI: 10.3389/fnhum.2018.00202
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/41926">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Carlos Ventura-Bort
Janine Wirkner
Hannah Genheimer
Julia Wendt
Alfons O. Hamm
Mathias Weymar
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
473
eng
uncontrolled
EEG
eng
uncontrolled
P300
eng
uncontrolled
tVNS
eng
uncontrolled
norepinephrine
eng
uncontrolled
locus coeruleus
eng
uncontrolled
salivary alpha-amylase
Medizin und Gesundheit
open_access
Referiert
Open Access
Department Psychologie
Institut für Psychologie
Universität Potsdam
https://publishup.uni-potsdam.de/files/41925/phr473.online.pdf
41926
2018
2018
eng
1
12
12
article
Frontiers Research Foundation
Lausanne
1
2018-06-21
2018-06-21
--
Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level
Recent research suggests that the P3b may be closely related to the activation of the locus coeruleus-norepinephrine (LC-NE) system. To further study the potential association, we applied a novel technique, the non-invasive transcutaneous vagus nerve stimulation (tVNS), which is speculated to increase noradrenaline levels. Using a within-subject cross-over design, 20 healthy participants received continuous tVNS and sham stimulation on two consecutive days (stimulation counterbalanced across participants) while performing a visual oddball task. During stimulation, oval non-targets (standard), normal-head (easy) and rotated-head (difficult) targets, as well as novel stimuli (scenes) were presented. As an indirect marker of noradrenergic activation we also collected salivary alpha-amylase (sAA) before and after stimulation. Results showed larger P3b amplitudes for target, relative to standard stimuli, irrespective of stimulation condition. Exploratory post hoc analyses, however, revealed that, in comparison to standard stimuli, easy (but not difficult) targets produced larger P3b (but not P3a) amplitudes during active tVNS, compared to sham stimulation. For sAA levels, although main analyses did not show differential effects of stimulation, direct testing revealed that tVNS (but not sham stimulation) increased sAA levels after stimulation. Additionally, larger differences between tVNS and sham stimulation in P3b magnitudes for easy targets were associated with larger increase in sAA levels after tVNS, but not after sham stimulation. Despite preliminary evidence for a modulatory influence of tVNS on the P3b, which may be partly mediated by activation of the noradrenergic system, additional research in this field is clearly warranted. Future studies need to clarify whether tVNS also facilitates other processes, such as learning and memory, and whether tVNS can be used as therapeutic tool.
Frontiers in Human Neuroscience
A Pilot Study
10.3389/fnhum.2018.00202
1662-5161
Universität Potsdam, Publikationsfonds
PA 2018_26
1995.09
online registration
202
<a href="http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-419259">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 473</a>
CC-BY - Namensnennung 4.0 International
Carlos Ventura-Bort
Janine Wirkner
Hannah Genheimer
Julia Wendt
Alfons O. Hamm
Mathias Weymar
eng
uncontrolled
EEG
eng
uncontrolled
P300
eng
uncontrolled
tVNS
eng
uncontrolled
norepinephrine
eng
uncontrolled
locus coeruleus
eng
uncontrolled
salivary alpha-amylase
Medizin und Gesundheit
open_access
Referiert
Publikationsfonds der Universität Potsdam
Open Access
Department Psychologie
Institut für Psychologie
48208
2019
2019
eng
S12
S12
1
56
other
Wiley
Hoboken
1
--
--
--
Effects of Transcutaneous Vagus Vagus Nerve Stimulation (TVNS) on
selective attentions and emotional episodic memory : findings from ERP research
Recent research indicates that non- invasive stimulation of the afferent auricular vagal nerve (tVNS) may modulate various cognitive and affec-tive functions, likely via activation of the locus coeruleus- norepinephrine (LC- NE) system. In a series of ERP studies we found that the attention- related P300 component is enhanced during continuous vagal stimula-tion, compared to sham, which is also related to increased salivary alpha amylase levels (a putative indirect marker for central NE activation). In another study, we investigated the effect of continuous tVNS on the late positive potential (LPP), an electrophysiological index for motivated atten-tion toward emotionally evocative cues, and the effects of tVNS on later recognition memory (1- week delay). Here, vagal stimulation prompted earlier LPP differences (300- 500 ms) between unpleasant and neutral scenes. During retrieval, vagal stimulation significantly improved memory performance for unpleasant, but not neutral pictures, compared to sham stimulation, which was also related to enhanced salivary alpha amylase levels. In line, unpleasant images encoded under tVNS compared to sham stimulation also produced enhanced ERP old/new differences (500- 800 ms) during retrieval indicating better recollection. Taken together, our studies suggest that tVNS facilitates attention, learning and episodic memory, likely via afferent projections to the arousal- modulated LC- NE system. We will, however, also show data that point to critical stimulation parameters (likely duration and frequency) that need to be considered when applying tVNS
Psychophysiology : journal of the Society for Psychophysiological Research
0048-5772
1469-8986
10.1111/psyp.13501
wos:2019
59th Annual Meeting of the Society-for-Psychophysiological-Research (SPR)
SEP 25-29, 2019
WOS:000494324000039
Washington, DC
importub
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true
Mathias Weymar
Carlos Ventura-Bort
Janine Wirkner
Hannah Genheimer
Julia Wendt
Alfons O. Hamm
Psychologie
Referiert
Department Psychologie
Import
46139
2017
2017
eng
S145
S145
1
54
other
Wiley
Hoboken
1
--
--
--
THE P300 AND THE LC-NE SYSTEM: NEW INSIGHTS FROM TRANSCUTANEOUS VAGUS NERVE STIMULATION (TVNS)
Psychophysiology : journal of the Society for Psychophysiological Research
0048-5772
1469-8986
wos:2017
57th Annual Meeting of the Society-for-Psychophysiological-Research
OCT 11-15, 2017
WOS:000415045300585
Vienna, AUSTRIA
importub
2020-04-19T22:59:01+00:00
filename=package.tar
f73901db18e441d9fa1f817986d98025
Mathias Weymar
Carlos Ventura-Bort
Hannah Genheimer
Janine Wirkner
Julia Wendt
Alfons O. Hamm
eng
uncontrolled
P300
eng
uncontrolled
norepinephrine
eng
uncontrolled
transcutaneous vagus nerve stimulation
Referiert
Department Psychologie
Import
Institut für Psychologie