50042
2019
2019
eng
279
300
22
3
34
article
Springer
Dordrecht
EArly Genetics Lifecourse EGG Consortium EGG Membership EAGLE Membership
1
--
2019-03-18
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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
European journal of epidemiology
design, results and future prospects
10.1007/s10654-019-00502-9
30887376
0393-2990
1573-7284
wos:2019
WOS:000463834200009
Middeldorp, CM (reprint author), Univ Queensland, Child Hlth Res Ctr, Brisbane, Qld, Australia., c.middeldorp@uq.edu.au
the Marie Sklodowska-Curie grantEuropean Union (EU) [721567]; European Sir Henry Dale Fellowship (Wellcome Trust); Sir Henry Dale Fellowship (Royal Society) [WT104150]; American Diabetes AssociationAmerican Diabetes Association [1-17-PDF-077]; Dutch Science Organization (ZonMW-VENI Grant) [916.14.023]; Australian National Health and Medical Research Council Early Career FellowshipNational Health and Medical Research Council of Australia [APP1104818]; Gene-Diet Interactions in Obesity (GENDINOB) project; National Institute of Health ResearchNational Institute for Health Research (NIHR); European Research CouncilEuropean Research Council (ERC) [323195 SZ-245 Endowed Chair in Genomic Research; National Institute for Health Research (NIHR) Senior Investigator AwardNational Institute for Health Research (NIHR) [NF-SI-0611-10219]; German Research Society, German Ministry of Education and Research; American Diabetes Association (ADA) Pathway Program Accelerator Early Investigator Award [1-15-ACE-26]; Helse Vest [23929]; Bergen Forskningsstiftelse; KG Jebsen Foundation; University of Bergen; Academy of Finland Research Professor programAcademy of Finland [265240, 263278]; University of Queensland Development Fellowship [UQFEL1718945]; Li Ka Shing Foundation; WT-SSI/John Fell funds; NIHR Biomedical Research Centre, OxfordNational Institute for Health Research (NIHR); Widenlife; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [5P50HD028138-27]; NHMRC Senior Reseach FellowshipNational Health and Medical Research Council of Australia [APP1103623]; career development fellowship [20308]; Wellcome TrustWellcome Trust [WT098395, WT098051, WT205915, 098051]; National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children Horizon 2020 research; European Union FP7-IDEAS-ERC Advanced Grant (GEPIDIAB) [ERC-AG -ERC-294785]; European Union FP7-IDEAS-ERC innovation programme (DYNAhealth) [H2020-PHC-2014-633595]; CRUKCancer Research UK [C18281/A19169]; NHMRC Practitioner Fellowship GrantNational Health and Medical Research Council of Australia [APP1105807]; European Regional Development Fund (ERDF)European Union (EU); European Social Fund (ESF)European Social Fund (ESF); Convergence Programme for Cornwall; Isles of Scilly; Diabetes Research and Wellness Foundation Non-Clinical de Recerca Agaur (AGAUR)Generalitat de Catalunya [2015 FI_B 00636]; ZonMWNetherlands Organization for Health Research and Development [TOP 40-00812-98-11010]; MRC Human Genetics Unit quinquennial programme "QTL in Health and Disease"; Diabetes UK RD Lawrence fellowshipDiabetes UK [17/0005594]; BBMRI-NL [CP2013-50]; Novo Nordisk FoundationNovo Nordisk Foundation [12955]; Oak Foundation Fellowship; European Research Council (ERC)European Research Council (ERC); KG Jebsen; European Research (FP/2007-2013)/ERC Grant [669545]; US National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 DK10324]; UK Medical Research CouncilMedical Research Council UK (MRC) [MC_UU_00011/6]; Wellcome Trust GWAS grantWellcome Trust [WT088806]; NIHR Senior Investigator Award [NF-SI-0611-10196]; NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol; UK Medical Research Council Unit [MC_UU_12013_5, MC_UU_12013_4]; University of Bristol NIHR Biomedical Research Centre (BRC) [202802/Z/16/Z, WT 102215/2/13/2]; CRUK Integrative Cancer Epidemiology Programme [C18281/A19169]; Netherlands Organization for Health Research and Development (NWO)Netherlands Organization for Scientific Research (NWO)Netherlands Organization for Health Research and Development [ZonMw-VIDI 016.136.361]; European Research Council Consolidator GrantEuropean Research Council (ERC) [ERC-2014-CoG-648916]; Australian Research Council Future FellowshipAustralian Research Council [FT130101709]; NHMRC Senior Research FellowshipNational Health and Medical Research Council of Australia [GNT1137714]; Daniel B. Burke Endowed Chair for Diabetes Research; Spinozapremie [NWO-56-464-14192]; Royal Netherlands Academy of Science Professor Award [PAH/6635]; NIHRNational Institute for Health Research (NIHR) [NF-SI-0617-10090]; Wellcome [090532, 098381, 203141]; [R01 HD056465]
2021-03-23T09:32:47+00:00
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Middeldorp, Christel M.
McCarthy, Mark I.
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CC-BY - Namensnennung 4.0 International
Christel M. Middeldorp
Anubha Mahajan
Momoko Horikoshi
Neil R. Robertson
Robin N. Beaumont
Jonathan P. Bradfield
Mariona Bustamante
Diana L. Cousminer
Felix R. Day
N. Maneka De Silva
Monica Guxens
Dennis O. Mook-Kanamori
Beate St Pourcain
Nicole M. Warrington
Linda S. Adair
Emma Ahlqvist
Tarunveer Singh Ahluwalia
Peter Almgren
Wei Ang
Mustafa Atalay
Juha Auvinen
Meike Bartels
Jacques S. Beckmann
Jose Ramon Bilbao
Tom Bond
Judith B. Borja
Alana Cavadino
Pimphen Charoen
Zhanghua Chen
Lachlan Coin
Cyrus Cooper
John A. Curtin
Adnan Custovic
Shikta Das
Gareth E. Davies
George V. Dedoussis
Liesbeth Duijts
Peter R. Eastwood
Anders U. Eliasen
Paul Elliott
Johan G. Eriksson
Xavier Estivill
Joao Fadista
Iryna O. Fedko
Timothy M. Frayling
Romy Gaillard
W. James Gauderman
Frank Geller
Frank Gilliland
Vincente Gilsanz
Raquel Granell
Niels Grarup
Leif Groop
Dexter Hadley
Hakon Hakonarson
Torben Hansen
Catharina A. Hartman
Andrew T. Hattersley
M. Geoffrey Hayes
Johannes Hebebrand
Joachim Heinrich
Oyvind Helgeland
Anjali K. Henders
John Henderson
Tine B. Henriksen
Joel N. Hirschhorn
Marie-France Hivert
Berthold Hocher
John W. Holloway
Patrick Holt
Jouke-Jan Hottenga
Elina Hypponen
Carmen Iniguez
Stefan Johansson
Astanand Jugessur
Mika Kahonen
Heidi J. Kalkwarf
Jaakko Kaprio
Ville Karhunen
John P. Kemp
Marjan Kerkhof
Gerard H. Koppelman
Antje Korner
Sailesh Kotecha
Eskil Kreiner-Moller
Benard Kulohoma
Ashish Kumar
Zoltan Kutalik
Jari Lahti
Joan M. Lappe
Henrik Larsson
Terho Lehtimaki
Alexandra M. Lewin
Jin Li
Paul Lichtenstein
Cecilia M. Lindgren
Virpi Lindi
Allan Linneberg
Xueping Liu
Jun Liu
William L. Lowe
Sebastian Lundstrom
Leo-Pekka Lyytikainen
Ronald C. W. Ma
Aurelien Mace
Reedik Magi
Per Magnus
Abdullah A. Mamun
Minna Mannikko
Nicholas G. Martin
Hamdi Mbarek
Nina S. McCarthy
Sarah E. Medland
Mads Melbye
Erik Melen
Karen L. Mohlke
Claire Monnereau
Camilla S. Morgen
Andrew P. Morris
Jeffrey C. Murray
Ronny Myhre
Jackob M. Najman
Michel G. Nivard
Ellen A. Nohr
Ilja M. Nolte
Ioanna Ntalla
Sharon E. Oberfield
Emily Oken
Albertine J. Oldehinkel
Katja Pahkala
Teemu Palviainen
Kalliope Panoutsopoulou
Oluf Pedersen
Craig E. Pennell
Goran Pershagen
Niina Pitkanen
Robert Plomin
Christine Power
Rashmi B. Prasad
Inga Prokopenko
Lea Pulkkinen
Katri Raikkonen
Olli T. Raitakari
Rebecca M. Reynolds
Rebecca C. Richmond
Fernando Rivadeneira
Alina Rodriguez
Richard J. Rose
Rany Salem
Loreto Santa-Marina
Seang-Mei Saw
Theresia M. Schnurr
James G. Scott
Saskia Selzam
John A. Shepherd
Angela Simpson
Line Skotte
Patrick M. A. Sleiman
Harold Snieder
Thorkild I. A. Sorensen
Marie Standl
Eric A. P. Steegers
David P. Strachan
Leon Straker
Timo Strandberg
Michelle Taylor
Yik-Ying Teo
Elisabeth Thiering
Maties Torrent
Jessica Tyrrell
Andre G. Uitterlinden
Toos van Beijsterveldt
Peter J. van der Most
Cornelia M. van Duijn
Jorma Viikari
Natalia Vilor-Tejedor
Suzanne Vogelezang
Judith M. Vonk
Tanja G. M. Vrijkotte
Eero Vuoksimaa
Carol A. Wang
William J. Watkins
H-Erich Wichmann
Gonneke Willemsen
Gail M. Williams
James F. Wilson
Naomi R. Wray
Shujing Xu
Cheng-Jian Xu
Hanieh Yaghootkar
Lu Yi
Mohammad Hadi Zafarmand
Eleftheria Zeggini
Babette S. Zemel
Anke Hinney
Timo A. Lakka
Andrew J. O. Whitehouse
Jordi Sunyer
Elisabeth E. Widen
Bjarke Feenstra
Sylvain Sebert
Bo Jacobsson
Pal R. Njolstad
Camilla Stoltenberg
George Davey Smith
Debbie A. Lawlor
Lavinia Paternoster
Nicholas J. Timpson
Ken K. Ong
Hans Bisgaard
Klaus Bonnelykke
Vincent W. V. Jaddoe
Henning Tiemeier
Marjo-Riitta Jarvelin
David M. Evans
John R. B. Perry
Struan F. A. Grant
Dorret I. Boomsma
Rachel M. Freathy
Mark I. McCarthy
Janine F. Felix
eng
uncontrolled
Genetics
eng
uncontrolled
Consortium
eng
uncontrolled
Childhood traits and disorders
eng
uncontrolled
Longitudinal
Biowissenschaften; Biologie
Institut für Biochemie und Biologie
Referiert
Import
Hybrid Open-Access
39159
2015
2015
eng
1155
1168
14
4
24
article
Oxford Univ. Press
Oxford
Early Genetics Lifecourse, Genetic Invest ANthropometric, Early Growth Genetics EGG
1
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A novel common variant in DCST2 is associated with length in early life and height in adulthood
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
Human molecular genetics
10.1093/hmg/ddu510
25281659
0964-6906
1460-2083
wos:2015
WOS:000350138300021
Jaddoe, VWV (reprint author), Sophias Childrens Hosp, Erasmus Med Ctr, Dept Epidemiol, Generat Study Grp R, Postbus 2060, NL-3000 CB Rotterdam, Netherlands., v.jaddoe@erasmusmc.nl
Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust)
[085541/Z/08/Z]; Danish Council for Independent Research Medical
Sciences (FSS) The Alfred Benzon Foundation; Oak Foundation fellowship;
Wellcome Trust [090532]; European Research Council [SZ-245
50371-GLUCOSEGENES-FP7-IDEAS-ERC]; Netherlands Organization for Health
Research and Development [VIDI 016.136.367, VIDI 016.136.361]
Ralf J. P. van der Valk
Eskil Kreiner-Moller
Marjolein N. Kooijman
Monica Guxens
Evangelia Stergiakouli
Annika Saaf
Jonathan P. Bradfield
Frank Geller
M. Geoffrey Hayes
Diana L. Cousminer
Antje Koerner
Elisabeth Thiering
John A. Curtin
Ronny Myhre
Ville Huikari
Raimo Joro
Marjan Kerkhof
Nicole M. Warrington
Niina Pitkanen
Ioanna Ntalla
Momoko Horikoshi
Riitta Veijola
Rachel M. Freathy
Yik-Ying Teo
Sheila J. Barton
David M. Evans
John P. Kemp
Beate St Pourcain
Susan M. Ring
George Davey Smith
Anna Bergstrom
Inger Kull
Hakon Hakonarson
Frank D. Mentch
Hans Bisgaard
Bo Lund Krogsgaard Chawes
Jakob Stokholm
Johannes Waage
Patrick Eriksen
Astrid Sevelsted
Mads Melbye
Cornelia M. van Duijn
Carolina Medina-Gomez
Albert Hofman
Johan C. de Jongste
H. Rob Taal
Andre G. Uitterlinden
Loren L. Armstrong
Johan Eriksson
Aarno Palotie
Mariona Bustamante
Xavier Estivill
Juan R. Gonzalez
Sabrina Llop
Wieland Kiess
Anubha Mahajan
Claudia Flexeder
Carla M. T. Tiesler
Clare S. Murray
Angela Simpson
Per Magnus
Verena Sengpiel
Anna-Liisa Hartikainen
Sirkka Keinanen-Kiukaanniemi
Alexandra Lewin
Alexessander Da Silva Couto Alves
Alexandra I. F. Blakemore
Jessica L. Buxton
Marika Kaakinen
Alina Rodriguez
Sylvain Sebert
Marja Vaarasmaki
Timo Lakka
Virpi Lindi
Ulrike Gehring
Dirkje S. Postma
Wei Ang
John P. Newnham
Leo-Pekka Lyytikainen
Katja Pahkala
Olli T. Raitakari
Kalliope Panoutsopoulou
Eleftheria Zeggini
Dorret I. Boomsma
Maria Groen-Blokhuis
Jorma Ilonen
Lude Franke
Joel N. Hirschhorn
Tune H. Pers
Liming Liang
Jinyan Huang
Berthold Hocher
Mikael Knip
Seang-Mei Saw
John W. Holloway
Erik Melen
Struan F. A. Grant
Bjarke Feenstra
William L. Lowe
Elisabeth Widen
Elena Sergeyev
Harald Grallert
Adnan Custovic
Bo Jacobsson
Marjo-Riitta Jarvelin
Mustafa Atalay
Gerard H. Koppelman
Craig E. Pennell
Harri Niinikoski
George V. Dedoussis
Mark I. Mccarthy
Timothy M. Frayling
Jordi Sunyer
Nicholas J. Timpson
Fernando Rivadeneira
Klaus Bonnelykke
Vincent W. V. Jaddoe
Institut für Ernährungswissenschaft
Referiert