53521
2018
2018
eng
742
756
15
4
27
article
Oxford Univ. Press
Oxford
Early Growth Genetics EGG
1
2018-01-03
2018-01-03
--
Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics
Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86 577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother-child pairs to quantify the separate maternal and fetal genetic effects. Maternal SNPs at 10 loci (MTNR1B, HMGA2, SH2B3, KCNAB1, L3MBTL3, GCK, EBF1, TCF7L2, ACTL9, CYP3A7) were associated with offspring birth weight at P< 5 x 10(-8). In SEM analyses, at least 7 of the 10 associations were consistent with effects of the maternal genotype acting via the intrauterine environment, rather than via effects of shared alleles with the fetus. Variants, or correlated proxies, at many of the loci had been previously associated with adult traits, including fasting glucose (MTNR1B, GCK and TCF7L2) and sex hormone levels (CYP3A7), and one (EBF1) with gestational duration. The identified associations indicate that genetic effects on maternal glucose, cytochrome P450 activity and gestational duration, and potentially on maternal blood pressure and immune function, are relevant for fetal growth. Further characterization of these associations in mechanistic and causal analyses will enhance understanding of the potentially modifiable maternal determinants of fetal growth, with the goal of reducing the morbidity and mortality associated with low and high birth weights.
Human molecular genetics
10.1093/hmg/ddx429
29309628
0964-6906
1460-2083
wos:2018
WOS:000424137500014
Lawlor, DA (reprint author), Univ Bristol, Med Res Council Integrat Epidemiol Unit, Oakfield House,Oakfield Rd, Bristol BS8 2BN, Avon, England.; Freathy, RM (reprint author), Univ Exeter, Royal Devon & Exeter Hosp, Med Sch, RILD Bldg, Exeter EX2 5DW, Devon, England.; Feenstra, B (reprint author), Statens Serum Inst, Dept Epidemiol Res, Artillerivej 5, DK-2300 Copenhagen S, Denmark.; Evans, DM (reprint author), Univ Queensland, Diamantina Inst, Brisbane, Qld, Australia., d.evans1@uq.edu.au; d.a.lawlor@bristol.ac.uk; fee@ssi.dk; r.freathy@ex.ac.uk
European Regional Development Fund (ERDF)European Union (EU); European Social Fund (ESF) Convergence Programme for Cornwall and the Isles of Scilly; European Research Council (ERC)European Research Council (ERC) [SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC, ERC-2014-CoG-648916]; University of Bergen, KG Jebsen; University of Bergen, Helse Vest; Wellcome Trust Senior Investigator AwardsWellcome Trust [WT098395, WT098381]; National Institute for Health Research (NIHR) Senior Investigator AwardNational Institute for Health Research (NIHR) [NF-SI-0611-10219]; Sir Henry Dale Fellowship (Wellcome Trust); Sir Henry Dale Fellowship (Royal Society grant) [WT104150]; 4-year studentship [WT083431MF]; European Research Council under the European US National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 DK10324]; Wellcome Trust GWAS grantWellcome Trust [WT088806]; NIHR Senior Investigator Award [NF-SI-0611-10196]; Wellcome Trust Institutional Strategic Support AwardWellcome Trust [WT097835MF]; Diabetes Research and Wellness Foundation Non-Clinical Fellowship; Australian National Health and Medical Research Council Early Career FellowshipNational Health and Medical Research Council of Australia [APP1104818]; Daniel B. Burke Endowed Chair for Diabetes Research; UK Medical Research Council Unit grants [MC_UU_12013_5, MC_UU_12013_4]; Medical Research CouncilMedical Research Council UK (MRC) [MR/M005070/1]; Australian Research Council Future FellowshipAustralian Research Council [FT130101709, FT110100548]; NIHR Oxford Biomedical Research Centre (BRC); Oak Foundation Fellowship; Novo Nordisk FoundationNovo Nordisk Foundation [12955]; Canadian Diabetes Association; Institute of Genetics-Canadian Institute of Health Research (CIHR); CIHR-Frederick Banting and Charles Best Canada Graduate ScholarshipsCanadian Institutes of Health Research (CIHR); FRQS; Netherlands Organization for Health Research and DevelopmentNetherlands Organization for Health Research and Development [ZonMw-VIDI 016.136.361]; National Institute on AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG29451]; PRIN funds of the University of Ferrara; European Foundation for the Study of Diabetes (EFSD) Albert Renold Travel Fellowships for Young Scientists; ENGAGE Exchange and Mobility Program for ENGAGE training funds, ENGAGE project [HEALTH-F4-2007-201413]; ESRCEconomic & Social Research Council (ESRC) [RES-060-23-0011]; National Institute of Health ResearchNational Institute for Health Research (NIHR); Australian NHMRC Fellowships SchemeNational Health and Medical Research Council of Australia [619667]; Charity Open Access Fund (COAF)
2022-01-19T14:02:29+00:00
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<a href="https://doi.org/10.25932/publishup-42310">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 628 </a>
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Alana Cavadino
Jessica Tyrrell
Michael Nodzenski
Momoko Horikoshi
Frank Geller
Ronny Myhre
Rebecca C. Richmond
Lavinia Paternoster
Jonathan P. Bradfield
Eskil Kreiner-Moller
Ville Huikari
Sarah Metrustry
Kathryn L. Lunetta
Jodie N. Painter
Jouke-Jan Hottenga
Catherine Allard
Sheila J. Barton
Ana Espinosa
Julie A. Marsh
Catherine Potter
Ge Zhang
Wei Ang
Diane J. Berry
Luigi Bouchard
Shikta Das
Hakon Hakonarson
Jani Heikkinen
Oyvind Helgeland
Berthold Hocher
Albert Hofman
Hazel M. Inskip
Samuel E. Jones
Manolis Kogevinas
Penelope A. Lind
Letizia Marullo
Sarah E. Medland
Anna Murray
Jeffrey C. Murray
Pal R. Njolstad
Ellen A. Nohr
Christoph Reichetzeder
Susan M. Ring
Katherine S. Ruth
Loreto Santa-Marina
Denise M. Scholtens
Sylvain Sebert
Verena Sengpiel
Marcus A. Tuke
Marc Vaudel
Michael N. Weedon
Gonneke Willemsen
Andrew R. Wood
Hanieh Yaghootkar
Louis J. Muglia
Meike Bartels
Caroline L. Relton
Craig E. Pennell
Leda Chatzi
Xavier Estivill
John W. Holloway
Dorret I. Boomsma
Grant W. Montgomery
Joanne M. Murabito
Tim D. Spector
Christine Power
Marjo-Ritta Jarvelin
Hans Bisgaard
Struan F. A. Grant
Thorkild I. A. Sorensen
Vincent W. Jaddoe
Bo Jacobsson
Mads Melbye
Mark I. McCarthy
Andrew T. Hattersley
M. Geoffrey Hayes
Timothy M. Frayling
Marie-France Hivert
Janine F. Felix
Elina Hypponen
William L. Lowe
David M. Evans
Debbie A. Lawlor
Bjarke Feenstra
Rachel M. Freathy
Biowissenschaften; Biologie
Institut für Biochemie und Biologie
Referiert
Import
Hybrid Open-Access
50042
2019
2019
eng
279
300
22
3
34
article
Springer
Dordrecht
EArly Genetics Lifecourse EGG Consortium EGG Membership EAGLE Membership
1
--
2019-03-18
--
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
European journal of epidemiology
design, results and future prospects
10.1007/s10654-019-00502-9
30887376
0393-2990
1573-7284
wos:2019
WOS:000463834200009
Middeldorp, CM (reprint author), Univ Queensland, Child Hlth Res Ctr, Brisbane, Qld, Australia., c.middeldorp@uq.edu.au
the Marie Sklodowska-Curie grantEuropean Union (EU) [721567]; European Sir Henry Dale Fellowship (Wellcome Trust); Sir Henry Dale Fellowship (Royal Society) [WT104150]; American Diabetes AssociationAmerican Diabetes Association [1-17-PDF-077]; Dutch Science Organization (ZonMW-VENI Grant) [916.14.023]; Australian National Health and Medical Research Council Early Career FellowshipNational Health and Medical Research Council of Australia [APP1104818]; Gene-Diet Interactions in Obesity (GENDINOB) project; National Institute of Health ResearchNational Institute for Health Research (NIHR); European Research CouncilEuropean Research Council (ERC) [323195 SZ-245 Endowed Chair in Genomic Research; National Institute for Health Research (NIHR) Senior Investigator AwardNational Institute for Health Research (NIHR) [NF-SI-0611-10219]; German Research Society, German Ministry of Education and Research; American Diabetes Association (ADA) Pathway Program Accelerator Early Investigator Award [1-15-ACE-26]; Helse Vest [23929]; Bergen Forskningsstiftelse; KG Jebsen Foundation; University of Bergen; Academy of Finland Research Professor programAcademy of Finland [265240, 263278]; University of Queensland Development Fellowship [UQFEL1718945]; Li Ka Shing Foundation; WT-SSI/John Fell funds; NIHR Biomedical Research Centre, OxfordNational Institute for Health Research (NIHR); Widenlife; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [5P50HD028138-27]; NHMRC Senior Reseach FellowshipNational Health and Medical Research Council of Australia [APP1103623]; career development fellowship [20308]; Wellcome TrustWellcome Trust [WT098395, WT098051, WT205915, 098051]; National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children Horizon 2020 research; European Union FP7-IDEAS-ERC Advanced Grant (GEPIDIAB) [ERC-AG -ERC-294785]; European Union FP7-IDEAS-ERC innovation programme (DYNAhealth) [H2020-PHC-2014-633595]; CRUKCancer Research UK [C18281/A19169]; NHMRC Practitioner Fellowship GrantNational Health and Medical Research Council of Australia [APP1105807]; European Regional Development Fund (ERDF)European Union (EU); European Social Fund (ESF)European Social Fund (ESF); Convergence Programme for Cornwall; Isles of Scilly; Diabetes Research and Wellness Foundation Non-Clinical de Recerca Agaur (AGAUR)Generalitat de Catalunya [2015 FI_B 00636]; ZonMWNetherlands Organization for Health Research and Development [TOP 40-00812-98-11010]; MRC Human Genetics Unit quinquennial programme "QTL in Health and Disease"; Diabetes UK RD Lawrence fellowshipDiabetes UK [17/0005594]; BBMRI-NL [CP2013-50]; Novo Nordisk FoundationNovo Nordisk Foundation [12955]; Oak Foundation Fellowship; European Research Council (ERC)European Research Council (ERC); KG Jebsen; European Research (FP/2007-2013)/ERC Grant [669545]; US National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 DK10324]; UK Medical Research CouncilMedical Research Council UK (MRC) [MC_UU_00011/6]; Wellcome Trust GWAS grantWellcome Trust [WT088806]; NIHR Senior Investigator Award [NF-SI-0611-10196]; NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol; UK Medical Research Council Unit [MC_UU_12013_5, MC_UU_12013_4]; University of Bristol NIHR Biomedical Research Centre (BRC) [202802/Z/16/Z, WT 102215/2/13/2]; CRUK Integrative Cancer Epidemiology Programme [C18281/A19169]; Netherlands Organization for Health Research and Development (NWO)Netherlands Organization for Scientific Research (NWO)Netherlands Organization for Health Research and Development [ZonMw-VIDI 016.136.361]; European Research Council Consolidator GrantEuropean Research Council (ERC) [ERC-2014-CoG-648916]; Australian Research Council Future FellowshipAustralian Research Council [FT130101709]; NHMRC Senior Research FellowshipNational Health and Medical Research Council of Australia [GNT1137714]; Daniel B. Burke Endowed Chair for Diabetes Research; Spinozapremie [NWO-56-464-14192]; Royal Netherlands Academy of Science Professor Award [PAH/6635]; NIHRNational Institute for Health Research (NIHR) [NF-SI-0617-10090]; Wellcome [090532, 098381, 203141]; [R01 HD056465]
2021-03-23T09:32:47+00:00
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Christel M. Middeldorp
Anubha Mahajan
Momoko Horikoshi
Neil R. Robertson
Robin N. Beaumont
Jonathan P. Bradfield
Mariona Bustamante
Diana L. Cousminer
Felix R. Day
N. Maneka De Silva
Monica Guxens
Dennis O. Mook-Kanamori
Beate St Pourcain
Nicole M. Warrington
Linda S. Adair
Emma Ahlqvist
Tarunveer Singh Ahluwalia
Peter Almgren
Wei Ang
Mustafa Atalay
Juha Auvinen
Meike Bartels
Jacques S. Beckmann
Jose Ramon Bilbao
Tom Bond
Judith B. Borja
Alana Cavadino
Pimphen Charoen
Zhanghua Chen
Lachlan Coin
Cyrus Cooper
John A. Curtin
Adnan Custovic
Shikta Das
Gareth E. Davies
George V. Dedoussis
Liesbeth Duijts
Peter R. Eastwood
Anders U. Eliasen
Paul Elliott
Johan G. Eriksson
Xavier Estivill
Joao Fadista
Iryna O. Fedko
Timothy M. Frayling
Romy Gaillard
W. James Gauderman
Frank Geller
Frank Gilliland
Vincente Gilsanz
Raquel Granell
Niels Grarup
Leif Groop
Dexter Hadley
Hakon Hakonarson
Torben Hansen
Catharina A. Hartman
Andrew T. Hattersley
M. Geoffrey Hayes
Johannes Hebebrand
Joachim Heinrich
Oyvind Helgeland
Anjali K. Henders
John Henderson
Tine B. Henriksen
Joel N. Hirschhorn
Marie-France Hivert
Berthold Hocher
John W. Holloway
Patrick Holt
Jouke-Jan Hottenga
Elina Hypponen
Carmen Iniguez
Stefan Johansson
Astanand Jugessur
Mika Kahonen
Heidi J. Kalkwarf
Jaakko Kaprio
Ville Karhunen
John P. Kemp
Marjan Kerkhof
Gerard H. Koppelman
Antje Korner
Sailesh Kotecha
Eskil Kreiner-Moller
Benard Kulohoma
Ashish Kumar
Zoltan Kutalik
Jari Lahti
Joan M. Lappe
Henrik Larsson
Terho Lehtimaki
Alexandra M. Lewin
Jin Li
Paul Lichtenstein
Cecilia M. Lindgren
Virpi Lindi
Allan Linneberg
Xueping Liu
Jun Liu
William L. Lowe
Sebastian Lundstrom
Leo-Pekka Lyytikainen
Ronald C. W. Ma
Aurelien Mace
Reedik Magi
Per Magnus
Abdullah A. Mamun
Minna Mannikko
Nicholas G. Martin
Hamdi Mbarek
Nina S. McCarthy
Sarah E. Medland
Mads Melbye
Erik Melen
Karen L. Mohlke
Claire Monnereau
Camilla S. Morgen
Andrew P. Morris
Jeffrey C. Murray
Ronny Myhre
Jackob M. Najman
Michel G. Nivard
Ellen A. Nohr
Ilja M. Nolte
Ioanna Ntalla
Sharon E. Oberfield
Emily Oken
Albertine J. Oldehinkel
Katja Pahkala
Teemu Palviainen
Kalliope Panoutsopoulou
Oluf Pedersen
Craig E. Pennell
Goran Pershagen
Niina Pitkanen
Robert Plomin
Christine Power
Rashmi B. Prasad
Inga Prokopenko
Lea Pulkkinen
Katri Raikkonen
Olli T. Raitakari
Rebecca M. Reynolds
Rebecca C. Richmond
Fernando Rivadeneira
Alina Rodriguez
Richard J. Rose
Rany Salem
Loreto Santa-Marina
Seang-Mei Saw
Theresia M. Schnurr
James G. Scott
Saskia Selzam
John A. Shepherd
Angela Simpson
Line Skotte
Patrick M. A. Sleiman
Harold Snieder
Thorkild I. A. Sorensen
Marie Standl
Eric A. P. Steegers
David P. Strachan
Leon Straker
Timo Strandberg
Michelle Taylor
Yik-Ying Teo
Elisabeth Thiering
Maties Torrent
Jessica Tyrrell
Andre G. Uitterlinden
Toos van Beijsterveldt
Peter J. van der Most
Cornelia M. van Duijn
Jorma Viikari
Natalia Vilor-Tejedor
Suzanne Vogelezang
Judith M. Vonk
Tanja G. M. Vrijkotte
Eero Vuoksimaa
Carol A. Wang
William J. Watkins
H-Erich Wichmann
Gonneke Willemsen
Gail M. Williams
James F. Wilson
Naomi R. Wray
Shujing Xu
Cheng-Jian Xu
Hanieh Yaghootkar
Lu Yi
Mohammad Hadi Zafarmand
Eleftheria Zeggini
Babette S. Zemel
Anke Hinney
Timo A. Lakka
Andrew J. O. Whitehouse
Jordi Sunyer
Elisabeth E. Widen
Bjarke Feenstra
Sylvain Sebert
Bo Jacobsson
Pal R. Njolstad
Camilla Stoltenberg
George Davey Smith
Debbie A. Lawlor
Lavinia Paternoster
Nicholas J. Timpson
Ken K. Ong
Hans Bisgaard
Klaus Bonnelykke
Vincent W. V. Jaddoe
Henning Tiemeier
Marjo-Riitta Jarvelin
David M. Evans
John R. B. Perry
Struan F. A. Grant
Dorret I. Boomsma
Rachel M. Freathy
Mark I. McCarthy
Janine F. Felix
eng
uncontrolled
Genetics
eng
uncontrolled
Consortium
eng
uncontrolled
Childhood traits and disorders
eng
uncontrolled
Longitudinal
Biowissenschaften; Biologie
Institut für Biochemie und Biologie
Referiert
Import
Hybrid Open-Access
35934
2012
2012
eng
532
+
9
5
44
article
Nature Publ. Group
New York
Cohorts Heart Aging Res Genetic Ep, Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti
1
--
--
--
Common variants at 12q15 and 12q24 are associated with infant head circumference
To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
Nature genetics
10.1038/ng.2238
1061-4036
wos:2011-2013
WOS:000303416300013
Smith, GD (reprint author), Univ Bristol, MRC, Ctr Causal Anal Translat Epidemiol, Sch Social & Community Med, Bristol, Avon, England., Julia.Mackay@bristol.ac.uk; heinrich@helmholtz-muenchen.de; m.jarvelin@imperial.ac.uk; v.jaddoe@erasmusmc.nl; heinrich@helmholtz-muenchen.de; v.jaddoe@erasmusmc.nl; m.jarvelin@imperial.ac.uk; heinrich@helmholtz-muenchen.de; v.jaddoe@erasmusmc.nl; m.jarvelin@imperial.ac.uk
Academy of Finland [104781, 120315, 129269, 1114194, 134839, 129287];
Biocentrum Helsinki; Biocenter, University of Oulu, Finland; British
Heart Foundation; Canadian Institutes of Health Research [MOP 82893];
The Children's Hospital of Philadelphia; Cotswold Foundation; Darlington
Trust; Dutch Asthma Foundation; Dutch Ministry of the Environment;
Erasmus Medical Center Rotterdam; Erasmus University Rotterdam; European
Community [HEALTH-F4-2007-201413]; Exeter National Health Service (NHS)
Research and Development; Fundacio La Marato de TV3 (Televisio de
Catalunya); Helmholtz Zentrum Muenchen; German Research Center for
Environment and Health; Institute of Epidemiology I; Neuherberg;
Instituto de Salud Carlos III [FIS PI081151, PS09/00432]; Institut fur
Umweltmedizinische Forschung (IUF) Dusseldorf; Marien-Hospital Wesel; UK
MRC [G0500539, G0600331, G0600705]; Municipal Health Service Rotterdam;
National Health and Medical Research Council of Australia [403981,
003209]; National Public Health Institute, Helsinki, Finland;
Netherlands Organisation for Scientific Research (NWO); Netherlands
Organisation for Health Research and Development (ZonMw) [SPI
56-464-14192, 904-61-090, 904-61-193, 912-03-031, 480-04-004,
400-05-717]; US NHLBI [5R01HL087679-02, 1RL1MH083268-01]; US NIH
[1R01HD056465-01A1]; Peninsula NIHR Clinical Research Facility; RAINE
Medical Research Foundation; Rotterdam Homecare Foundation; South West
NHS Research and Development; Stichting Astmabestrijding; Stichting
Trombosedienst & Artsenlaboratorium Rijnmond (STAR) Rotterdam; Technical
University Munich; Telethon Institute for Child Health Research;
UFZ-Centre for Environmental Research Leipzig-Halle; University Hospital
Oulu, Finland; University of Bristol; University of Leipzig; Wellcome
Trust [GR069224, 085541/Z/08/Z, WT083431MA, WT088431MA]; Western
Australian DNA Bank; Western Australian Genetic Epidemiology Resource;
ZonMW [21000074]; Dutch Kidney Foundation [C08.2251]; MRC UK [G0500539,
PS0476]; MRC [MRC G0800582]; Netherlands Organisation for Health
Research (ZonMw) [90700303, 916.10159]
H. Rob Taal
Beate St Pourcain
Elisabeth Thiering
Shikta Das
Dennis O. Mook-Kanamori
Nicole M. Warrington
Marika Kaakinen
Eskil Kreiner-Moller
Jonathan P. Bradfield
Rachel M. Freathy
Frank Geller
Monica Guxens
Diana L. Cousminer
Marjan Kerkhof
Nicholas J. Timpson
M. Arfan Ikram
Lawrence J. Beilin
Klaus Bonnelykke
Jessica L. Buxton
Pimphen Charoen
Bo Lund Krogsgaard Chawes
Johan Eriksson
David M. Evans
Albert Hofman
John P. Kemp
Cecilia E. Kim
Norman Klopp
Jari Lahti
Stephen J. Lye
George McMahon
Frank D. Mentch
Martina Mueller-Nurasyid
Paul F. O'Reilly
Inga Prokopenko
Fernando Rivadeneira
Eric A. P. Steegers
Jordi Sunyer
Carla Tiesler
Hanieh Yaghootkar
Monique M. B. Breteler
Stephanie Debette
Myriam Fornage
Vilmundur Gudnason
Lenore J. Launer
Aad van der Lugt
Thomas H. Mosley
Sudha Seshadri
Albert V. Smith
Meike W. Vernooij
Alexandra I. F. Blakemore
Rosetta M. Chiavacci
Bjarke Feenstra
Julio Fernandez-Banet
Struan F. A. Grant
Anna-Liisa Hartikainen
Albert J. van der Heijden
Carmen Iniguez
Mark Lathrop
Wendy L. McArdle
Anne Molgaard
John P. Newnham
Lyle J. Palmer
Aarno Palotie
Annneli Pouta
Susan M. Ring
Ulla Sovio
Marie Standl
Andre G. Uitterlinden
H-Erich Wichmann
Nadja Hawwa Vissing
Charles DeCarli
Cornelia M. van Duijn
Mark I. McCarthy
Gerard H. Koppelman
Xavier Estivill
Andrew T. Hattersley
Mads Melbye
Hans Bisgaard
Craig E. Pennell
Elisabeth Widen
Hakon Hakonarson
George Davey Smith
Joachim Heinrich
Marjo-Riitta Jarvelin
Vincent W. V. Jaddoe
Linda S. Adair
Wei Ang
Mustafa Atalay
Toos van Beijsterveldt
Nienke Bergen
Kelly Benke
Diane J. Berry
Jonathan P. Bradfield
Pimphen Charoen
Lachlan Coin
Diana L. Cousminer
Shikta Das
Oliver S. P. Davis
Paul Elliott
David M. Evans
Bjarke Feenstra
Claudia Flexeder
Tim Frayling
Rachel M. Freathy
Romy Gaillard
Frank Geller
Maria Groen-Blokhuis
Liang-Kee Goh
Monica Guxens
Claire M. A. Haworth
Dexter Hadley
Johannes Hebebrand
Anke Hinney
Joel N. Hirschhorn
John W. Holloway
Claus Holst
Jouke Jan Hottenga
Momoko Horikoshi
Ville Huikari
Elina Hypponen
Carmen Iniguez
Marika Kaakinen
Tuomas O. Kilpelainen
Mirna Kirin
Matthew Kowgier
Hanna-Maaria Lakka
Leslie A. Lange
Debbie A. Lawlor
Terho Lehtimaki
Alex Lewin
Cecilia Lindgren
Virpi Lindi
Reedik Maggi
Julie Marsh
Christel Middeldorp
Iona Millwood
Dennis O. Mook-Kanamori
Jeffrey C. Murray
Michel Nivard
Ellen Aagaard Nohr
Ioanna Ntalla
Emily Oken
Paul F. O'Reilly
Lyle J. Palmer
Kalliope Panoutsopoulou
Jennifer Pararajasingham
Inga Prokopenko
Alina Rodriguez
Rany M. Salem
Sylvain Sebert
Niina Siitonen
Ulla Sovio
Beate St Pourcain
David P. Strachan
Jordi Sunyer
H. Rob Taal
Yik-Ying Teo
Elisabeth Thiering
Carla Tiesler
Andre G. Uitterlinden
Beatriz Valcarcel
Nicole M. Warrington
Scott White
Gonneke Willemsen
Hanieh Yaghootkar
Eleftheria Zeggini
Dorret I. Boomsma
Cyrus Cooper
Xavier Estivill
Matthew Gillman
Struan F. A. Grant
Hakon Hakonarson
Andrew T. Hattersley
Joachim Heinrich
Berthold Hocher
Vincent W. V. Jaddoe
Marjo-Riitta Jarvelin
Timo A. Lakka
Mark I. McCarthy
Mads Melbye
Karen L. Mohlke
George V. Dedoussis
Ken K. Ong
Ewan R. Pearson
Craig E. Pennell
Thomas S. Price
Chris Power
Olli T. Raitakari
Seang-Mei Saw
Andre Scherag
Olli Simell
Thorkild I. A. Sorensen
Nicholas J. Timpson
Elisabeth Widen
James F. Wilson
Wei Ang
Toos van Beijsterveldt
Nienke Bergen
Kelly Benke
Diane J. Berry
Jonathan P. Bradfield
Pimphen Charoen
Lachlan Coin
Diana L. Cousminer
Shikta Das
Paul Elliott
David M. Evans
Tim Frayling
Rachel M. Freathy
Romy Gaillard
Maria Groen-Blokhuis
Monica Guxens
Dexter Hadley
Jouke Jan Hottenga
Ville Huikari
Elina Hypponen
Marika Kaakinen
Matthew Kowgier
Debbie A. Lawlor
Alex Lewin
Cecilia Lindgren
Julie Marsh
Christel Middeldorp
Iona Millwood
Dennis O. Mook-Kanamori
Michel Nivard
Paul F. O'Reilly
Lyle J. Palmer
Inga Prokopenko
Alina Rodriguez
Sylvain Sebert
Ulla Sovio
Beate St Pourcain
Marie Standl
David P. Strachan
Jordi Sunyer
H. Rob Taal
Elisabeth Thiering
Carla Tiesler
Andre G. Uitterlinden
Beatriz Valcarcel
Nicole M. Warrington
Scott White
Gonneke Willemsen
Hanieh Yaghootkar
Dorret I. Boomsma
Xavier Estivill
Struan F. A. Grant
Hakon Hakonarson
Andrew T. Hattersley
Joachim Heinrich
Vincent W. V. Jaddoe
Marjo-Riitta Jarvelin
Mark I. McCarthy
Craig E. Pennell
Chris Power
Nicholas J. Timpson
Elisabeth Widen
M. Arfan Ikram
Myriam Fornage
Albert V. Smith
Sudha Seshadri
Reinhold Schmidt
Stephanie Debette
Henri A. Vrooman
Sigurdur Sigurdsson
Stefan Ropele
Laura H. Coker
W. T. Longstreth
Wiro J. Niessen
Anita L. DeStefano
Alexa Beiser
Alex P. Zijdenbos
Maksim Struchalin
Clifford R. Jack
Mike A. Nalls
Rhoda Au
Albert Hofman
Haukur Gudnason
Aad van der Lugt
Tamara B. Harris
William M. Meeks
Meike W. Vernooij
Mark A. van Buchem
Diane Catellier
Vilmundur Gudnason
B. Gwen Windham
Philip A. Wolf
Cornelia M. van Duijn
Thomas H. Mosley
Helena Schmidt
Lenore J. Launer
Monique M. B. Breteler
Charles DeCarli
Institut für Biochemie und Biologie
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