62969
2023
eng
2161
2171
11
13
37
article
Taylor & Francis
London [u.a.]
1
2022-02-09
2022-02-09
--
A new C-C linked benzophenathridine-2-quinoline dimer, and the antiplasmodial activity of alkaloids from Zanthoxylum holstzianum
The CH2Cl2/MeOH (1:1) extract of Zanthoxylum holstzianum stem bark showed good antiplasmodial activity (IC50 2.5 +/- 0.3 and 2.6 +/- 0.3 mu g/mL against the W2 and D6 strains of Plasmodium falciparum, respectively). From the extract five benzophenanthridine alkaloids [8-acetonyldihydrochelerythrine (1), nitidine (2), dihydrochelerythine (3), norchelerythrine (5), arnottianamide (8)]; a 2-quinolone alkaloid [N-methylflindersine (4)]; a lignan [4,4 '-dihydroxy-3,3 '-dimethoxylignan-9,9 '-diyl diacetate (7)] and a dimer of a benzophenanthridine and 2-quinoline [holstzianoquinoline (6)] were isolated. The CH2Cl2/MeOH (1:1) extract of the root bark afforded 1, 3-6, 8, chelerythridimerine (9) and 9-demethyloxychelerythrine (10). Holstzianoquinoline (6) is new, and is the second dimer linked by a C-C bond of a benzophenanthridine and a 2-quinoline reported thus far. The compounds were identified based on spectroscopic evidence. Amongst five compounds (1-5) tested against two strains of P. falciparum, nitidine (IC50 0.11 +/- 0.01 mu g/mL against W2 and D6 strains) and norchelerythrine (IC50 value of 0.15 +/- 0.01 mu g/mL against D6 strain) were the most active.
Natural product research
10.1080/14786419.2022.2034810
35139708
1478-6419
1478-6427
outputup:dataSource:WoS:2022
WOS:000753835000001
Yenesew, Abiy (corresponding author), Univ Nairobi, Dept Chem, Nairobi, Kenya., ayenesew@uonbi.ac.ke
German Academic Exchange Services (DAAD) through the Natural Products; Research Network for Eastern and Central Africa (NAPRECA); International; Science Program (ISP Sweden) [KEN-02]; Kenya Medical Research; Institute's Internal Research Grant [L-183]
Yenesew, Abiy
2024-03-14T13:28:05+00:00
sword
importub
filename=package.tar
467c368e0d7d9906438fa347b31ce2bf
false
true
Denis Akampurira
Hoseah M. Akala
Solomon Derese
Matthias Heydenreich
Abiy Yenesew
eng
uncontrolled
Antiplasmodial
eng
uncontrolled
benzophenanthridine alkaloid
eng
uncontrolled
holstzianoquinoline;
eng
uncontrolled
rutaceae
eng
uncontrolled
Zanthoxylum holstzianum
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Import
55194
2017
2017
eng
8
17
article
BioMed Central
London
1
2017-03-24
2017-03-24
--
Anti-plasmodial activity of Norcaesalpin D and extracts of four medicinal plants used traditionally for treatment of malaria
Background: Malaria is an old life-threatening parasitic disease that is still affecting many people, mainly children living in sub-Saharan Africa. Availability of effective antimalarial drugs played a significant role in the treatment and control of malaria. However, recent information on the emergence of P. falciparum parasites resistant to one of the artemisinin-based combination therapies suggests the need for discovery of new drug molecules. Therefore, this study aimed to evaluate the antiplasmodial activity of extracts, fractions and isolated compound from medicinal plants traditionally used in the treatment of malaria in Tanzania. Methods: Dry powdered plant materials were extracted by cold macerations using different solvents. Norcaesalpin D was isolated by column chromatography from dichloromethane root extract of Caesalpinia bonducella and its structure was assigned based on the spectral data. Crude extracts, fractions and isolated compound were evaluated for antiplasmodial activity against chloroquine-sensitive P. falciparum (3D7), chloroquine-resistant P. falciparum (Dd2, K1) and artemisinin-resistant P. falciparum (IPC 5202 Battambang, IPC 4912 Mondolkiri) strains using the parasite lactate dehydrogenase assay. Results: The results indicated that extracts of Erythrina schliebenii, Holarrhena pubescens, Dissotis melleri and C. bonducella exhibited antiplasmodial activity against Dd2 parasites. Ethanolic root extract of E. schliebenii had an IC50 of 1.87 mu g/mL while methanolic and ethanolic root extracts of H. pubescens exhibited an IC50 = 2.05 mu g/mL and IC50 = 2.43 mu g/mL, respectively. Fractions from H. pubescens and C. bonducella roots were found to be highly active against K1, Dd2 and artemisinin-resistant parasites. Norcaesalpin D from C. bonducella root extract was active with IC50 of 0.98, 1.85 and 2.13 mu g/mL against 3D7, Dd2 and IPC 4912-Mondolkiri parasites, respectively. Conclusions: Antiplasmodial activity of norcaesalpin D and extracts of E. schliebenii, H. pubescens, D. melleri and C. bonducella reported in this study requires further attention for the discovery of antimalarial lead compounds for future drug development.
BMC Complementary and Alternative Medicine volume
10.1186/s12906-017-1673-8
1472-6882
wos:2017
167
WOS:000397780600001
Nondo, O (reprint author), Muhimbili Univ Hlth & Allied Sci, Inst Tradit Med, Dept Biol & Pre Clin Studies, POB 65001, Dar Es Salaam, Tanzania., rnondo@muhas.ac.tz
onds der Chemischen Industrie
2022-06-16T06:02:23+00:00
sword
importub
filename=package.tar
6daff6951e55dda4099a479303f99b1f
Selemani, Ramadhani Selemani Omari
<a href="https://doi.org/10.25932/publishup-42832">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 707 </a>
false
true
CC-BY - Namensnennung 4.0 International
Ramadhani Selemani Omari Selemani
Omari Nondo
Mainen Julius Moshi
Paul Erasto
Pax Jessey Masimba
Francis Machumi
Abdul Waziri Kidukuli
Matthias Heydenreich
Denis Zofou
eng
uncontrolled
Antiplasmodial
eng
uncontrolled
norcaesalpin D
eng
uncontrolled
E. schliebenii
eng
uncontrolled
H. pubescens
eng
uncontrolled
D. melleri
eng
uncontrolled
C. bonducella
Medizin und Gesundheit
Institut für Chemie
Referiert
Import
36793
2011
2011
eng
176
178
3
2
4
article
Elsevier
Amsterdam
1
--
--
--
Terpurinflavone an antiplasmodial flavone from the stem of Tephrosia Purpurea
The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC(50) values of 10.47 +/- 2.22 mu g/ml and 12.06 +/- 2.54 mu g/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC(50) values of 3.12 +/- 0.28 mu M (D6) and 6.26 +/- 2.66 mu M (W2). The structures were determined on the basis of spectroscopic evidence.
Phytochemistry letters
10.1016/j.phytol.2011.02.010
1874-3900
wos:2011-2013
WOS:000290788100027
Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197-00100, Nairobi, Kenya., ayenesew@uonbi.ac.ke
Deutche Forschungemeinschaft (DFG), Germany; Germany Federal Ministry
for Economic Cooperation and Development (BMZ) within the DFG/BMZ
Wanyama P. Juma
Hoseah M. Akala
Fredrick L. Eyase
Lois M. Muiva
Matthias Heydenreich
Faith A. Okalebo
Peter M. Gitu
Martin G. Peter
Douglas S. Walsh
Mabel Imbuga
Abiy Yenesew
eng
uncontrolled
Tephrosia purpurea
eng
uncontrolled
Leguminosae
eng
uncontrolled
Stem
eng
uncontrolled
Flavone
eng
uncontrolled
Terpurinflavone
eng
uncontrolled
Antiplasmodial
Institut für Chemie
Referiert
35674
2012
2012
eng
1123
1126
4
9
7
article
NPC
Westerville
1
--
--
--
Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus
The CH2Cl2-MeOH (1:1) extract of the aerial parts of Sphaeranthus bullatus, an annual herb native to tropical East Africa, showed activity against chloroquine sensitive D6 (IC50 9.7 mu g/mL) and chloroquine resistant W2 (IC50 15.0 mu g/mL) strains of Plasmodium falciparum. Seventeen secondary metabolites were isolated from the extract through conventional chromatographic techniques and identified using various spectroscopic methods. The compounds were evaluated for their in vitro antiplasmodial, antileishmanial and anticancer activities revealing activity of four carvotacetone derivatives, namely 3-acetoxy-7-hydroxy-5-tigloyloxycarvotacetone (1) 3,7-dihydroxy-5-tigloyloxycarvotacetone (2), 3-acetoxy-5,7-dihydroxycarvotacetone (3) and 3,5,7-trihydroxycarvotacetone (4); with antiplasmodial IC50 values of 1.40, 0.79, 0.60 and 3.40 mu g/mL, respectively, against chloroquine sensitive D6 strains of P. falciparum; antiplasmodial activity of IC50 2.00, 0.90, 0.68 and 2.80 mu g/mL respectively, against chloroquine resistant W2 strains of P. falciparum, antileishmanial IC50, values of 0.70, 3.00, 0.70 and 17.00 mu g/mL, respectively, against the parasite L. donovanii promastigotes, and anticancer activity against human SK-MEL, KB, BT-549 and SK-OV-3 tumor cells, with IC50 values between <1.1 - 5.3 mu g/mL, for 1-3. In addition, cytotoxic effects of the active compounds were evaluated against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11). The structures of carvotacetone derivatives were determined by ID and 2D NMR spectroscopy; the absolute stereochemical configuration of 3-acetoxy-7-hydroxy-5-tigloyloxycarvotacetone (I) was determined as 3R, 4R, 5S by circular dichroism, specific rotation, H-1 NMR and 2D NMR ROESY and NOESY experiments.
Natural product communications : an international journal for communications and reviews
1934-578X
wos:2011-2013
WOS:000309319700002
Midiwo, JO (reprint author), Univ Nairobi, Dept Chem, POB 30197 00100, Nairobi, Kenya., jmidiwo@nonbi.ac.ke; milias@olemiss.edu
US Department of Defense CDMRP [W81XWH-09]; USDA Agricultural Research
Service [58-6408-2-0009]; German Academic Exchange Service (DAAD);
Natural Products Research Network for Eastern and Central Africa
(NAPRECA)
Francis Machumi
Abiy Yenesew
Jacob O. Midiwo
Matthias Heydenreich
Erich Kleinpeter
Babu L. Tekwani
Shabana I. Khan
Larry A. Walker
Ilias Muhammad
eng
uncontrolled
Sphaeranthus bullatus
eng
uncontrolled
Asteraceae
eng
uncontrolled
Antiplasmodial
eng
uncontrolled
Antileishmanial
eng
uncontrolled
Anticancer
eng
uncontrolled
Carvotacetones
Institut für Chemie
Referiert